Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA topoisomerase 0.091
DNA gyrase 0.042
topoisomerase I 0.027
topoisomerase II alpha 0.007
TOP2A 0.006
type I DNA topoisomerase 0.005
ICRF 0.005
DNA topoisomerase I 0.005
DNA topoisomerase 1 0.004
topoisomerase II beta 0.002
RMI1 0.002
TOP1 0.002
TOP2B 0.002
topo II beta 0.001
DNA topoisomerase III 0.001
TOP3 0.001
TDP1 0.001
RMI2 0.001
TOP2A protein 0.001
Tyrosyl-DNA phosphodiesterase 1 0.001
tyrosyl-DNA phosphodiesterase 1 0.001
TOP1mt 0.001
TOP1MT 0.001
SPO11 0.001
ICB1 0.001
MX2 0.001
P-glycoprotein 0.000
mitochondrial topoisomerase I 0.000
MLL 0.000
helicase 0.000
TOP3A 0.000
PICH 0.000
TOP3B 0.000
ATP 0.000
BLM 0.000
H2AX 0.000
Mariner transposase 0.000
DNA helicase 0.000
C9orf82 0.000
p53 0.000
DNA-dependent protein kinase 0.000
ICBP90 0.000
mdr1 0.000
MIC 0.000
TOP 0.000
SLFN11 0.000
ATM 0.000
LIX1L 0.000
shugoshin-like 2 0.000
ELOF1 0.000
ubiquitin specific peptidase 42 0.000
TOP1 protein 0.000
TTRAP 0.000
TOP2 beta 0.000
DNA polymerase alpha 0.000
Mol 0.000
Chk1 0.000
MRP 0.000
AML 0.000
irs-2 0.000
TDRD3 0.000
MUS81 0.000
DNA polymerase 0.000
PARP 0.000
Type I DNA topoisomerase 0.000
PRRC1 0.000
dedicator of cytokinesis 10 0.000
CKBBP2 0.000
RBP56/CHN 0.000
NLRP13 0.000
SFRS7 0.000
breakpoint cluster region 0.000
poly(ADP-ribose) polymerase 0.000
MDR1 0.000
DNA topoisomerase 2 0.000
Chk2 0.000
Tudor domain-containing protein 3 0.000
DNA ligase 0.000
ATPase 0.000
multidrug resistance associated protein 0.000
more...
Disease
cancer 0.001
leukemia 0.000
BLM 0.000
Therapy-related myelodysplastic syndrome 0.000
acute myeloid leukemia 0.000
CEM 0.000
tumor 0.000
vaccinia 0.000
L.donovani 0.000
secondary AML 0.000
ATM 0.000
MCF 0.000
recurrent PNET 0.000
mouse leukemia L1210 0.000
myelodysplastic syndrome 0.000
WRN 0.000
small cell lung cancer 0.000
breast cancer 0.000
MDS 0.000
Teratoma with malignant transformation 0.000
SCAN1 0.000
acute promyelocytic leukemia 0.000
colon cancer 0.000
lung cancer 0.000
Leukemia 0.000
ovarian cancer 0.000
lung carcinoma 0.000
acute leukemia 0.000
SMC 0.000
acute lymphoblastic leukemia 0.000
scleroderma 0.000
myeloid leukemia 0.000
carcinoma 0.000
non-small cell lung cancer 0.000
childhood ependymoma 0.000
TAS 0.000
Shope fibroma 0.000
PSS 0.000
APL 0.000
APL 0.000
lymphoma 0.000
leukemogenesis 0.000
bacterial conjunctivitis 0.000
solid tumor 0.000
PanIN-1A 0.000
MAR 0.000
PanIN-1B 0.000
adenocarcinoma 0.000
CREST 0.000
Axonal Neuropathy 0.000
Drug resistant tuberculosis 0.000
Fanconi 0.000
secondary myelodysplastic syndromes 0.000
melanoma 0.000
urogenital gonorrhea 0.000
de novo myelodysplastic syndromes 0.000
AML/MDS 0.000
neutropenia 0.000
SAR 0.000
lymphoblastic leukemia 0.000
Idiopathic hypoparathyroidism 0.000
myelosuppression 0.000
APL 0.000
TAM 0.000
amok 0.000
glioblastoma 0.000
FPD/AML 0.000
RTS 0.000
childhood ANLL 0.000
carcinogenesis 0.000
tumor growth 0.000
epithelial ovarian cancer 0.000
HER-2 positive breast cancer 0.000
adult soft tissue sarcoma 0.000
colorectal cancer 0.000
histiocytic lymphoma 0.000
prostate cancer 0.000
osteosarcoma 0.000
erythroleukemia 0.000
limited-stage small cell lung cancer 0.000
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Symptom
diarrhea 0.000
disturbed balance 0.000
collapse 0.000
ataxia 0.000
starvation 0.000
autodigestion 0.000
No adverse effect 0.000
asthenia 0.000
Halo 0.000
nausea and vomiting 0.000
decreased appetite 0.000
ophthalmoplegia 0.000
menopausal symptoms 0.000
HSA 0.000
nausea 0.000
dyspnea 0.000
eds 0.000
hypoproteinemia 0.000
night sweats 0.000
muscle stiffness 0.000
vomiting 0.000
tonic-clonic seizure 0.000
skin damage 0.000
cerebellar ataxia 0.000
incoordination 0.000
apathy 0.000
chills 0.000
rhinorrhea 0.000
hyperoxia 0.000
dysuria 0.000
splenomegaly 0.000
fatigue 0.000
hoarseness 0.000
bone pain 0.000
colic 0.000
anorexia 0.000
cough 0.000
syncope 0.000
hepatosplenomegaly 0.000
headache 0.000
paresthesia 0.000
abdominal pain 0.000
hepatomegaly 0.000
erythema 0.000
hypotonia 0.000
seizures 0.000
weakness 0.000
sleepiness 0.000
functional recovery 0.000
exhaustion 0.000
pain 0.000
discomfort 0.000
discomfort 0.000
anesthesia 0.000
Drug
Etoposide 0.004
CPT-11 0.001
Dexrazoxane 0.001
Sobuzoxane 0.000
Adriamycin 0.000
BLM 0.000
Pixantrone 0.000
Irinotecan 0.000
TTC 0.000
Teniposide 0.000
Aclarubicin 0.000
Gemifloxacin 0.000
Gemifloxacin mesylate 0.000
Edotecarin 0.000
Premafloxacin 0.000
Sitafloxacin 0.000
MDS 0.000
DNase I 0.000
ADR 0.000
Podophyllotoxin 0.000
Moxifloxacin 0.000
Avelox 0.000
Idarubicin 0.000
Podophyllum 0.000
Tetrahydropyran 0.000
Tirapazamine 0.000
Irofulven 0.000
Mutagen 0.000
Ilmofosine 0.000
PZFX 0.000
Radicicol 0.000
Gatifloxacin 0.000
VCR 0.000
1,2,4-Triazole 0.000
Etoposide phosphate 0.000
Gemzar 0.000
Menogaril 0.000
VCR 0.000
Taxotere 0.000
AraC 0.000
Asn 0.000
Herceptin 0.000
Tarivid 0.000
Myricetin 0.000
Taxol 0.000
Ofloxacin 0.000
caffeine 0.000
GEO 0.000
Enrofloxacin 0.000
Epidoxorubicin 0.000
Vorinostat 0.000
Docetaxel 0.000
Polysorbate 20 0.000
Compound 9 0.000
TEL 0.000
Gadoteridol 0.000
Gliadel 0.000
Rauwolfia serpentina 0.000
Vinorelbine 0.000
Xeloda 0.000
Pentostam 0.000
lysine 0.000
Dronedarone 0.000
Navelbine 0.000
Compound 19 0.000
Pirarubicin 0.000
NOV 0.000
ADM 0.000
ROS 0.000
Compound 16 0.000
Vindesine 0.000
Poudre 0.000
Vindesine 0.000
Compound 15 0.000
Glutathione 0.000
Zevalin 0.000
CED 0.000
CTX 0.000
Filgrastim 0.000
CTX 0.000
more...
Enzyme
topoisomerase 1.000
topoisomerase 0.910
P-glycoprotein 0.001
DNA polymerase 0.000
EC 5.99.1.1 0.000
PARP 0.000
DNA ligase 0.000
DNA ligase 0.000
ATPase 0.000
MDR 0.000
endonuclease 0.000
thymidylate synthase 0.000
RNA polymerase 0.000
hydroxypyruvate isomerase 0.000
ribonucleotide reductase 0.000
ribonucleotide reductase 0.000
caspase-3 0.000
CPT 0.000
caspase-2 0.000
CPT 0.000
kallikrein 10 0.000
RNase M5 0.000
protein kinase 0.000
phosphodiesterase 0.000
glutathione S-transferase 0.000
cdc2 0.000
caspase-2 0.000
CPT 0.000
ERK 0.000
polo-like kinase 1 0.000
proteasome 0.000
micrococcal nuclease 0.000
DNase II 0.000
polynucleotide kinase 0.000
nucleoside triphosphate phosphohydrolase 0.000
S-formylglutathione hydrolase 0.000
DNase 0.000
dihydrofolate reductase 0.000
endonuclease VII 0.000
dCMP hydroxymethylase 0.000
protein kinase C 0.000
RNase H 0.000
deoxycytidine kinase 0.000
RNase 0.000
caspase-9 0.000
DNA methyltransferase 0.000
lambda exonuclease 0.000
thymidine kinase 0.000
RNase 0.000
caspase-8 0.000
caspase-1 0.000
AP lyase 0.000
enzyme X 0.000
proteinase K 0.000
dUTPase 0.000
mitogen-activated protein kinase 0.000
S1 nuclease 0.000
dCMP deaminase 0.000
deoxycytidine deaminase 0.000
exonuclease V 0.000
PIP kinase 0.000
STK2 0.000
luciferase 0.000
NQO1 0.000
FabH 0.000
carboxylesterase 0.000
reverse transcriptase 0.000
PTR1 0.000
prolyl-tRNA synthetase 0.000
Protein 2 0.000
Escherichia coli exonuclease III 0.000
deoxyribonuclease 0.000
DSR 0.000
amidophosphoribosyltransferase 0.000
penicillopepsin 0.000
glutamate racemase 0.000
endodeoxyribonuclease 0.000
alanine racemase 0.000
IMP dehydrogenase 0.000
deoxyguanosine kinase 0.000
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Compound
m-AMSA 0.013
VP-16 0.008
DNA 0.004
VM-26 0.003
ICRF-187 0.001
Camptothecin 0.001
Camptothecin 0.001
Camptothecin 0.001
Novobiocin 0.001
Topotecan 0.001
Merbarone 0.001
SN-38 0.001
Topotecan 0.001
Ellipticine 0.001
CPT-11 0.001
Adriamycin 0.000
Psorospermin 0.000
CI-921 0.000
Fostriecin 0.000
ATP 0.000
ADR 0.000
Mitoxantrone 0.000
Mitoxantrone 0.000
acridine 0.000
MIC 0.000
Clorobiocin 0.000
BLM 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
8-Methoxycaffeine 0.000
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 0.000
Kinamycin C 0.000
Fagaronine 0.000
C15H12O5 0.000
C15H12O5 0.000
Podophyllotoxin acetate 0.000
6-bromo-9H-purine 0.000
N-ethylhydrazinecarbothioamide 0.000
Elsamicin 0.000
Cryptolepine 0.000
benzo[a]phenazine 0.000
Genistein 0.000
beta-Lapachone 0.000
C37H40N2O6 0.000
Usambarensine 0.000
2-butanone thiosemicarbazone 0.000
5H-indeno[1,2-b]pyridin-5-one 0.000
Lunacridine 0.000
Methoxycamptothecin 0.000
Licodione 0.000
Albamycin 0.000
Mitindomide 0.000
Lunacridine 0.000
2-(dimethylamino)ethyl 0.000
2-(dimethylamino)ethyl 0.000
2,6-piperazinedione 0.000
Nalidixic acid 0.000
Voacamine 0.000
6-methoxy-5,8-quinolinedione 0.000
C19H18O8 0.000
Sitafloxacin 0.000
MDR 0.000
C17H20N2O3 0.000
1-(phenylsulfonyl)-1H-indole 0.000
NMHE 0.000
Ciprofloxacin 0.000
2-hydroxynaphthoquinone 0.000
2-hydroxynaphthoquinone 0.000
Chloroquinoxaline sulfonamide 0.000
11H-indeno[1,2-b]quinoline 0.000
benzo[i]phenanthridine 0.000
Moxifloxacin hydrochloride 0.000
Mulberrofuran G 0.000
Methanesulfonanilide 0.000
11H-indeno[1,2-b]quinoline 0.000
tyrosine 0.000
ADP-ribose 0.000
Nogalamycin 0.000
more...