Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
shugoshin-like 2 11.8
ELOF1 11.8
TOP1mt 11.8
DNA topoisomerase 11.8
Mariner transposase 11.8
LIX1L 11.8
ubiquitin specific peptidase 42 11.8
type I DNA topoisomerase 11.6
ICB1 11.3
TOP2A protein 11.2
TOP1MT 11.2
topo II beta 11.2
C9orf82 11.2
DNA topoisomerase 1 11.1
DNA topoisomerase III 11.0
topoisomerase II beta 10.8
dedicator of cytokinesis 10 10.8
SFRS7 10.8
RMI2 10.8
CKBBP2 10.8
Type I DNA topoisomerase 10.8
mitochondrial topoisomerase I 10.8
NLRP13 10.8
RBP56/CHN 10.8
PRRC1 10.8
TOP2B 10.7
RMI1 10.7
topoisomerase II alpha 10.6
TOP3 10.6
TOP2 beta 10.4
TOP1 protein 10.4
TOP3A 10.4
ICRF 10.3
Tyrosyl-DNA phosphodiesterase 1 10.3
DNA gyrase 10.2
MGC4175 10.2
splicing factor 4 10.2
irs-2 10.2
Mucosal vascular addressin cell adhesion molecule 1 10.2
MOZ/CBP 10.2
topoisomerase IIb 10.2
KIAA1210 10.2
TDP1 10.2
TDP1 protein 10.2
TDRD3 10.2
TOP3B 10.0
TOP2A 10.0
PICH 9.9
topoisomerase I 9.8
tyrosyl-DNA phosphodiesterase 1 9.8
Tudor domain-containing protein 3 9.8
TOP1 9.7
FRYL 9.6
TRAF and TNF receptor-associated protein 9.6
DNA topoisomerase II beta 9.6
Mitotic kinesin-like protein 1 9.4
SNF2, histone-linker, PHD and RING finger domain-containing helicase 9.4
SFRS4 9.4
DNA topoisomerase 2 9.4
ataxin 10 9.4
HZW10 9.4
KIAA0020 9.4
ZNF214 9.4
DNA topoisomerase I 9.4
ICBP90 9.4
TTRAP 9.4
SPO11 9.3
SLFN11 9.3
SARL 9.2
HXA3 9.2
PMX1 9.2
E1A-like inhibitor of differentiation 3 9.2
MLL/AF4 fusion 9.2
TGGCA-binding protein 9.2
myeloid leukemia factor 2 9.2
Cys-X-Cys) 9.2
TAFI110 9.2
SLC46A3 9.0
40S ribosomal protein S12 9.0
Ribosomal protein L3 9.0
more...
Disease
recurrent PNET 10.8
Therapy-related myelodysplastic syndrome 9.8
L.donovani 9.7
Teratoma with malignant transformation 9.2
SCAN1 8.3
mouse leukemia L1210 8.0
childhood ependymoma 8.0
PanIN-1A 7.6
PanIN-1B 7.5
secondary AML 7.3
Axonal Neuropathy 7.3
Drug resistant tuberculosis 7.2
secondary myelodysplastic syndromes 7.2
urogenital gonorrhea 7.1
de novo myelodysplastic syndromes 7.0
Shope fibroma 6.9
Idiopathic hypoparathyroidism 6.9
amok 6.7
BLM 6.6
FPD/AML 6.6
bacterial conjunctivitis 6.6
childhood ANLL 6.6
HER-2 positive breast cancer 6.5
adult soft tissue sarcoma 6.4
recurrent SCLC 6.3
Reovirus infection 6.3
AML/MDS 6.2
PanIN-2 6.2
mouse leukemia P388 6.2
preneoplastic state 6.1
limited-stage small cell lung cancer 6.1
Argininosuccinic aciduria 6.1
CEM 6.1
WRN 6.1
Anaplastic carcinoma 6.0
PanIN-3 5.9
MDS 5.8
Theileriosis 5.8
SMC 5.8
APL 5.8
Subependymomas 5.7
APL 5.7
MCPH1 5.7
TAS 5.6
microbial disease 5.6
Infection induced 5.6
CREST 5.6
MAR 5.6
ABC-DLBCL 5.4
FAB M2 5.4
vaccinia 5.4
metastatic pheochromocytoma 5.3
small cell lung cancer 5.3
Alpers 5.3
Cerebral metastases 5.2
RAEB-T 5.2
CNS cancer 5.2
RTS 5.2
squamous cell carcinoma of the anus 5.1
recurrent ovarian cancer 5.1
ATM 5.1
acute undifferentiated leukemia 5.1
in situ breast cancer 5.1
diffuse scleroderma 5.0
Gastrointestinal Tumor 5.0
histiocytic lymphoma 5.0
XPF 5.0
adenocarcinoma of unknown primary 5.0
ODA 4.9
APL 4.9
pediatric solid tumor 4.9
Brill 4.8
myeloid leukemia 4.8
Traveler's diarrhea 4.8
mixed gliomas 4.8
acute monocytic leukemia 4.8
PanIN 4.8
Enzyme inhibition 4.8
myelodysplastic syndrome 4.8
molluscum contagiosum 4.8
more...
Symptom
disturbed balance 3.9
autodigestion 3.5
No adverse effect 3.4
Halo 2.9
decreased appetite 2.6
asthenia 2.4
menopausal symptoms 2.1
ophthalmoplegia 2.1
HSA 1.8
eds 1.7
hypoproteinemia 1.6
ataxia 1.6
night sweats 1.5
nausea and vomiting 1.5
muscle stiffness 1.5
tonic-clonic seizure 1.4
collapse 1.3
diarrhea 1.3
starvation 1.2
skin damage 1.2
incoordination 1.0
cerebellar ataxia 0.9
apathy 0.8
chills 0.7
rhinorrhea 0.6
nausea 0.6
dysuria 0.5
hyperoxia 0.4
dyspnea 0.3
hoarseness 0.2
bone pain 0.2
colic 0.1
splenomegaly 0.1
vomiting -0.0
hepatosplenomegaly -0.3
anorexia -0.4
syncope -0.4
paresthesia -0.5
hepatomegaly -0.7
hypotonia -0.8
cough -0.8
fatigue -0.9
erythema -0.9
abdominal pain -1.2
headache -1.4
weakness -1.9
sleepiness -1.9
seizures -1.9
functional recovery -2.0
exhaustion -2.0
discomfort -2.7
discomfort -2.8
pain -3.4
anesthesia -5.0
Drug
Sobuzoxane 11.2
Premafloxacin 10.2
Edotecarin 10.2
Pixantrone 9.7
Gemifloxacin mesylate 9.6
Etoposide 9.2
Aclarubicin 9.1
Dexrazoxane 9.1
Teniposide 8.8
Gemifloxacin 8.6
Sitafloxacin 8.4
Avelox 8.2
Tetrahydropyran 8.2
Ilmofosine 8.1
PZFX 8.0
Irofulven 7.8
Etoposide phosphate 7.5
1,2,4-Triazole 7.5
Podophyllotoxin 7.5
Irinotecan 7.4
CPT-11 7.4
Tirapazamine 7.3
Radicicol 7.3
BLM 7.2
Podophyllum 7.0
Idarubicin 6.9
Menogaril 6.8
TTC 6.8
Gatifloxacin 6.6
Moxifloxacin 6.5
Adriamycin 6.4
Tarivid 6.3
Gemzar 6.2
Epidoxorubicin 6.0
MDS 6.0
Polysorbate 20 5.9
ADR 5.8
Gadoteridol 5.8
VCR 5.8
Gliadel 5.7
Rauwolfia serpentina 5.7
Myricetin 5.5
Xeloda 5.5
Pentostam 5.4
Compound 9 5.4
Enrofloxacin 5.3
Dronedarone 5.3
Compound 19 5.3
Vorinostat 5.3
Taxotere 5.3
Navelbine 5.3
Pirarubicin 5.2
Compound 16 5.1
Vinorelbine 5.0
NOV 5.0
DNase I 5.0
Ofloxacin 4.9
Vindesine 4.9
AraC 4.9
Poudre 4.9
Vindesine 4.9
Compound 15 4.8
Zevalin 4.8
TEL 4.7
VCR 4.7
Mutagen 4.5
GEO 4.5
Atovaquone 4.4
Herceptin 4.3
Docetaxel 4.3
Filgrastim 4.3
CED 4.2
Pefloxacin 4.1
Novantrone 4.1
Filgrastim 4.1
Flavopiridol 4.1
Diamminedichloroplatinum 4.1
Taxol 4.0
Atovaquone 4.0
Fludarabine 3.9
more...
Enzyme
topoisomerase 11.8
EC 5.99.1.1 11.8
topoisomerase 11.6
hydroxypyruvate isomerase 9.2
RNase M5 8.0
kallikrein 10 8.0
S-formylglutathione hydrolase 6.9
nucleoside triphosphate phosphohydrolase 6.8
dCMP hydroxymethylase 6.5
endonuclease VII 6.1
DNA ligase 6.0
DNA ligase 6.0
P-glycoprotein 6.0
caspase-2 5.9
enzyme X 5.9
DNase II 5.8
caspase-2 5.8
lambda exonuclease 5.7
thymidylate synthase 5.6
polynucleotide kinase 5.5
MDR 5.5
AP lyase 5.5
ribonucleotide reductase 5.4
deoxycytidine deaminase 5.3
exonuclease V 5.3
dCMP deaminase 5.3
STK2 5.2
DNA polymerase 5.2
ribonucleotide reductase 5.1
deoxycytidine kinase 5.1
PIP kinase 5.1
dUTPase 5.1
prolyl-tRNA synthetase 5.1
PTR1 5.1
polo-like kinase 1 5.1
FabH 5.0
CPT 5.0
PARP 4.9
Escherichia coli exonuclease III 4.9
CPT 4.9
DSR 4.9
amidophosphoribosyltransferase 4.8
glutamate racemase 4.8
penicillopepsin 4.8
endodeoxyribonuclease 4.7
micrococcal nuclease 4.6
Protein 2 4.6
deoxyguanosine kinase 4.6
inosine triphosphatase 4.5
endonuclease 4.5
CPT 4.5
pseudouridine synthase 4.4
alanine racemase 4.4
ubiquinol-cytochrome c oxidoreductase 4.4
enoyl-ACP reductase 4.4
separase 4.4
3'-phosphatase 4.4
enoyl-ACP reductase 4.3
ScpA 4.3
coproporphyrinogen III oxidase 4.3
RNase H 4.2
pyruvate formate-lyase 4.2
phosphatidylserine decarboxylase 4.1
cdc2 4.1
3'-exonuclease 4.1
acyl carrier protein synthase 4.1
aspartase 4.0
GM3 synthase 4.0
poly(A) polymerase 4.0
dihydrofolate reductase 4.0
IMP dehydrogenase 3.9
chitin synthase 3.9
branched-chain aminotransferase 3.9
NCP 3.8
deoxyribonuclease 3.8
peptide deformylase 3.8
prolidase 3.8
spermidine/spermine N1-acetyltransferase 3.8
caspase-6 3.8
RNA polymerase 3.8
more...
Compound
Podophyllotoxin acetate 11.8
N-ethylhydrazinecarbothioamide 11.8
C15H12O5 11.8
C15H12O5 11.8
C15H12O5 11.8
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.8
C15H12O5 11.8
6-bromo-9H-purine 11.8
Kinamycin C 11.8
C15H12O5 11.8
C15H12O5 11.8
8-Methoxycaffeine 11.8
Psorospermin 11.3
Usambarensine 10.8
C37H40N2O6 10.8
5H-indeno[1,2-b]pyridin-5-one 10.8
Lunacridine 10.8
Albamycin 10.8
2-butanone thiosemicarbazone 10.8
Methoxycamptothecin 10.8
Licodione 10.8
Mitindomide 10.8
Lunacridine 10.8
m-AMSA 10.7
Merbarone 10.5
Elsamicin 10.4
6-methoxy-5,8-quinolinedione 10.2
C19H18O8 10.2
Voacamine 10.2
Fagaronine 10.0
benzo[a]phenazine 9.9
Fostriecin 9.9
CI-921 9.8
1-(phenylsulfonyl)-1H-indole 9.8
C17H20N2O3 9.8
Clorobiocin 9.8
ICRF-187 9.7
Methanesulfonanilide 9.4
Mulberrofuran G 9.4
11H-indeno[1,2-b]quinoline 9.4
Chloroquinoxaline sulfonamide 9.4
11H-indeno[1,2-b]quinoline 9.4
2,6-piperazinedione 9.4
Moxifloxacin hydrochloride 9.4
benzo[i]phenanthridine 9.4
Ellipticine 9.4
Novobiocin 9.3
VM-26 9.3
Bimolane 9.2
9-cis-Retinal 9.2
2-hydroxynaphthoquinone 9.2
C14H12O3 9.2
Cryptolepine 9.1
2-hydroxynaphthoquinone 9.1
VP-16 9.0
Pinobanksin 9.0
Rubrofusarin 9.0
2,3-dihydro-1H-cyclopenta[b]quinoline 9.0
Topotecan 8.9
Camptothecin 8.9
Camptothecin 8.9
Camptothecin 8.9
beta-Lapachone 8.9
C18H18N2O5 8.8
Illudin S 8.7
1-methyl-4-piperidinol 8.6
NMHE 8.6
[1,2,4]triazolo[1,5-a]pyridine 8.6
benzo[g]isoquinoline-5,10-dione 8.6
Nogalamycin 8.4
5,11-dimethyl-6H-pyrido[4,3-b]carbazole 8.4
Toxoflavin 8.4
Sitafloxacin 8.4
Topotecan 8.4
Quinalizarin 8.3
Wedelolactone 8.3
6H-indolo[2,3-b]quinoxaline 8.3
Diospyrin 8.3
Cyasorb 8.3
Rebeccamycin 8.2
more...