Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:5.99.1.2 (topoisomerase)
9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein DNA gyrase 1142 topoisomerase I 959 Mol 884 DNA topoisomerase 832 ATP 621 Sep 611 p53 368 P-glycoprotein 244 ATPase 227 DNA topoisomerase I 218 histone 189 TOP2A 183 helicase 182 MIC 176 thymus 159 topoisomerase II alpha 139 caspase-3 136 ICRF 124 endonuclease 118 polypeptide 117 NMR 117 DNA polymerase 111 PARP 104 p21 100 Bcl-2 99 H2AX 96 MLL 95 AML 93 ATM 87 telomeric 85 fused 84 Ki-67 77 DNase I 75 DNA-dependent protein kinase 70 TOP1 67 proteasome 66 poly(ADP-ribose) polymerase 66 HER2 66 Pseudomonas 65 ADP 63 MDR1 60 Chk1 59 phosphodiesterase 59 DNA helicase 59 BLM 58 DNA topoisomerase 1 56 c-myc 55 colon carcinoma 55 ATR 55 tyrosine kinase 55 type I DNA topoisomerase 53 SDS 52 BRCA1 50 epidermal growth factor receptor 50 DNA polymerase alpha 47 ubiquitin 47 histone H3 46 thymidylate synthase 45 mdr1 44 histone deacetylase 44 proliferating cell nuclear antigen 43 Pol 41 RNA polymerase II 40 bcl-2 40 MDS 40 glutathione S-transferase 39 MX2 39 GSH 39 Fas 39 glycoprotein 38 GST 38 ACS 38 estrogen receptor 38 cytochrome c 38 dimeric 37 osteosarcoma 37 MRP 37 topoisomerase II beta 37 DNA ligase 37 A-T 37 more...

Disease cancer 2377 tumor 1054 leukemia 607 breast cancer 355 acute myeloid leukemia 250 carcinoma 202 MCF 186 lung cancer 164 ATM 129 vaccinia 129 lymphoma 122 myelodysplastic syndrome 117 adenocarcinoma 112 colon cancer 108 melanoma 102 ovarian cancer 99 lung carcinoma 89 BLM 87 CEM 82 acute lymphoblastic leukemia 81 carcinogenesis 80 non-small cell lung cancer 77 tumor growth 76 small cell lung cancer 73 Leukemia 73 hepatocellular carcinoma 73 prostate cancer 73 colorectal cancer 70 metastases 65 Mycobacterium 64 acute promyelocytic leukemia 57 tuberculosis 55 HIV 53 acute leukemia 53 tumorigenesis 53 SDS 52 PSS 50 glioma 50 neutropenia 47 glioblastoma 44 neuroblastoma 44 WRN 42 MDS 40 sarcoma 40 scleroderma 39 multiple myeloma 39 GSH 39 solid tumor 38 anemia 38 osteosarcoma 38 Klebsiella 36 thrombocytopenia 35 Mycoplasma 34 Haemophilus 33 epithelial ovarian cancer 33 squamous cell carcinoma 32 myeloid leukemia 32 cervical cancer 30 SAR 30 tumor progression 30 infectious diseases 29 retinoblastoma 29 gastric cancer 29 leukemogenesis 28 secondary AML 28 leishmaniasis 26 myelosuppression 26 herpes simplex 26 Hodgkin's disease 26 malaria 25 pneumonia 25 Fanconi 24 pancreatic cancer 24 chronic myeloid leukemia 24 cold 22 immunodeficiency 22 fibrosarcoma 22 lymphoblastic leukemia 21 non-Hodgkin's lymphoma 20 AIDS 20 more...

Symptom diarrhea 40 collapse 20 starvation 17 ataxia 14 dyspnea 10 nausea 10 vomiting 9 nausea and vomiting 8 fatigue 8 pain 7 headache 6 seizures 6 ophthalmoplegia 4 cough 4 abdominal pain 4 asthenia 4 HSA 3 anorexia 3 weakness 3 splenomegaly 3 apathy 2 menopausal symptoms 2 erythema 2 hyperoxia 2 syncope 2 cerebellar ataxia 2 chills 2 decreased appetite 2 hoarseness 1 night sweats 1 hepatomegaly 1 muscle stiffness 1 bone pain 1 No adverse effect 1 eds 1 Halo 1 autodigestion 1 hepatosplenomegaly 1 skin damage 1 incoordination 1 sleepiness 1 disturbed balance 1 dysuria 1 paresthesia 1 hypoproteinemia 1 rhinorrhea 1 functional recovery 1 exhaustion 1 tonic-clonic seizure 1 discomfort 1 discomfort 1 hypotonia 1 anesthesia 1 colic 1

Drug Etoposide 196 Adriamycin 111 CPT-11 93 DNase I 75 TTC 60 BLM 58 lysine 55 Irinotecan 41 caffeine 40 MDS 40 Mutagen 39 ADR 34 Asn 32 Dexrazoxane 27 ROS 26 Gel 18 Taxol 15 ampicillin 15 CTX 14 Herceptin 13 Gemifloxacin 13 Glutathione 12 VCR 12 Teniposide 12 ABC 12 Moxifloxacin 12 CTX 11 CTX 11 Docetaxel 10 GEO 10 ADM 10 VCR 10 Aclarubicin 9 AraC 9 MAP 9 Pixantrone 8 Dermatol 8 Ofloxacin 7 Idarubicin 7 Podophyllotoxin 7 Cardiovasc 7 Taxotere 7 ascorbate 6 Leaf 6 Podophyllum 6 Sitafloxacin 6 TEL 6 Gatifloxacin 5 G-CSF 5 EPI 5 CSF 5 Vorinostat 4 Tirapazamine 4 Enrofloxacin 4 ACT 4 NADH 4 Gemzar 4 Alanine 4 AZT 4 AZT 4 Vinorelbine 4 Myricetin 4 ETS 4 Sobuzoxane 4 MRC 4 Ranitidine 3 Gefitinib 3 Monit 3 Ouabain 3 Bortezomib 3 Paraffin 3 Compound 9 3 CDP 3 CED 3 IL-2 3 PCP 3 Lovastatin 3 Fluconazole 3 Radicicol 3 Gemifloxacin mesylate 2 more...

Enzyme topoisomerase 9166 topoisomerase 9094 P-glycoprotein 247 ATPase 232 DNA polymerase 174 protein kinase 140 RNA polymerase 138 ERK 130 PARP 120 endonuclease 118 caspase-3 101 mitogen-activated protein kinase 74 glutathione S-transferase 70 protein kinase C 68 proteasome 67 phosphodiesterase 66 MDR 57 DNA ligase 52 DNA ligase 52 thymidylate synthase 51 cdc2 42 luciferase 39 ACS 38 RNase 38 ribonucleotide reductase 37 RNase 34 reverse transcriptase 34 DNase 30 CPT 29 CPT 29 CPT 29 ribonucleotide reductase 29 peroxidase 27 dihydrofolate reductase 26 focal adhesion kinase 26 caspase-9 24 thymidine kinase 23 trypsin 22 catalase 22 caspase-8 21 caspase-1 20 micrococcal nuclease 20 DNA methyltransferase 19 alkaline phosphatase 17 proteinase K 15 NQO1 15 polo-like kinase 1 15 RNase H 15 beta-galactosidase 14 caspase-2 14 S1 nuclease 13 caspase-2 12 MEK 12 lactate dehydrogenase 12 beta-lactamase 12 calcineurin 12 carboxylesterase 10 glutathione peroxidase 10 polynucleotide kinase 9 MAP 8 phosphoinositide 3-kinase 8 APC 7 glutathione reductase 7 kinesin 7 ornithine decarboxylase 7 CYP3A4 7 DNase II 7 demethylase 7 deoxycytidine kinase 7 hypoxanthine-guanine phosphoribosyltransferase 6 superoxide dismutase 6 ribonuclease 6 protein phosphatase 2A 6 ATP synthase 6 neuraminidase 6 cathepsin B 6 AMPK 6 chloramphenicol acetyltransferase 6 deoxyribonuclease 6 tyrosinase 6 more...

Compound DNA 5828 Dec 645 ATP 621 VP-16 469 m-AMSA 246 tyrosine 234 oxygen 220 Clin 205 Adriamycin 185 MIC 176 salt 163 VM-26 153 phosphate 147 hydrogen 130 sodium 119 MTT 118 acridine 113 ADR 112 water 110 serine 109 bromide 100 lysine 98 CPT-11 92 MDA 87 alanine 86 calcium 82 Camptothecin 81 Camptothecin 80 Camptothecin 80 nitrogen 77 SN-38 76 Mg2+ 76 Phe 73 arginine 72 sulfate 67 ADP 66 Asp 66 cysteine 64 ADP 63 ADP 63 leucine 62 BLM 60 MDR 57 ADP-ribose 56 SDS 55 threonine 54 Topotecan 54 Topotecan 54 quinoline 53 pyridine 53 quinoline 52 copper 51 zinc 51 glucose 50 iron 50 GSH 50 GSH 50 pyrimidine 49 pyrimidine 49 Novobiocin 48 ICRF-187 47 Genistein 46 benzene 44 caffeine 40 acetate 39 ACS 38 galactose 38 ACS 38 Ciprofloxacin 37 His 36 iodine 35 Mitoxantrone 34 Mitoxantrone 34 DDP 31 retinoic acid 31 CPT 31 Ile 29 potassium 29 CPT 29 EDTA 28 more...

---