Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ubiquitin specific peptidase 42 11.8
ELOF1 11.8
LIX1L 11.8
shugoshin-like 2 11.8
Mariner transposase 11.8
TOP1mt 11.8
DNA topoisomerase 11.8
type I DNA topoisomerase 11.6
ICB1 11.3
TOP2A protein 11.2
topo II beta 11.2
C9orf82 11.2
TOP1MT 11.2
DNA topoisomerase 1 11.1
DNA topoisomerase III 11.0
topoisomerase II beta 10.8
PRRC1 10.8
CKBBP2 10.8
NLRP13 10.8
RBP56/CHN 10.8
Type I DNA topoisomerase 10.8
RMI2 10.8
mitochondrial topoisomerase I 10.8
dedicator of cytokinesis 10 10.8
SFRS7 10.8
TOP2B 10.7
RMI1 10.7
topoisomerase II alpha 10.6
TOP3 10.6
TOP1 protein 10.4
TOP2 beta 10.4
TOP3A 10.4
ICRF 10.3
Tyrosyl-DNA phosphodiesterase 1 10.3
DNA gyrase 10.2
MOZ/CBP 10.2
KIAA1210 10.2
MGC4175 10.2
splicing factor 4 10.2
TDP1 protein 10.2
more...
Disease
recurrent PNET 10.8
Therapy-related myelodysplastic syndrome 9.8
L.donovani 9.7
Teratoma with malignant transformation 9.2
SCAN1 8.3
mouse leukemia L1210 8.0
childhood ependymoma 8.0
PanIN-1A 7.6
PanIN-1B 7.5
secondary AML 7.3
Axonal Neuropathy 7.3
Drug resistant tuberculosis 7.2
secondary myelodysplastic syndromes 7.2
urogenital gonorrhea 7.1
de novo myelodysplastic syndromes 7.0
Idiopathic hypoparathyroidism 6.9
Shope fibroma 6.9
amok 6.7
BLM 6.6
FPD/AML 6.6
bacterial conjunctivitis 6.6
childhood ANLL 6.6
HER-2 positive breast cancer 6.5
adult soft tissue sarcoma 6.4
recurrent SCLC 6.3
Reovirus infection 6.3
AML/MDS 6.2
PanIN-2 6.2
mouse leukemia P388 6.2
preneoplastic state 6.1
limited-stage small cell lung cancer 6.1
Argininosuccinic aciduria 6.1
CEM 6.1
WRN 6.1
Anaplastic carcinoma 6.0
PanIN-3 5.9
MDS 5.8
Theileriosis 5.8
SMC 5.8
APL 5.8
more...
Symptom
disturbed balance 3.9
autodigestion 3.5
No adverse effect 3.4
Halo 2.9
decreased appetite 2.6
asthenia 2.4
menopausal symptoms 2.1
ophthalmoplegia 2.1
HSA 1.8
eds 1.7
hypoproteinemia 1.6
ataxia 1.6
night sweats 1.5
nausea and vomiting 1.5
muscle stiffness 1.5
tonic-clonic seizure 1.4
collapse 1.3
diarrhea 1.3
starvation 1.2
skin damage 1.2
incoordination 1.0
cerebellar ataxia 0.9
apathy 0.8
chills 0.7
rhinorrhea 0.6
nausea 0.6
dysuria 0.5
hyperoxia 0.4
dyspnea 0.3
hoarseness 0.2
bone pain 0.2
colic 0.1
splenomegaly 0.1
vomiting -0.0
hepatosplenomegaly -0.3
anorexia -0.4
syncope -0.4
paresthesia -0.5
hepatomegaly -0.7
hypotonia -0.8
more...
Drug
Sobuzoxane 11.2
Edotecarin 10.2
Premafloxacin 10.2
Pixantrone 9.7
Gemifloxacin mesylate 9.6
Etoposide 9.2
Aclarubicin 9.1
Dexrazoxane 9.1
Teniposide 8.8
Gemifloxacin 8.6
Sitafloxacin 8.4
Avelox 8.2
Tetrahydropyran 8.2
Ilmofosine 8.1
PZFX 8.0
Irofulven 7.8
1,2,4-Triazole 7.5
Etoposide phosphate 7.5
Podophyllotoxin 7.5
Irinotecan 7.4
CPT-11 7.4
Tirapazamine 7.3
Radicicol 7.3
BLM 7.2
Podophyllum 7.0
Idarubicin 6.9
Menogaril 6.8
TTC 6.8
Gatifloxacin 6.6
Moxifloxacin 6.5
Adriamycin 6.4
Tarivid 6.3
Gemzar 6.2
Epidoxorubicin 6.0
MDS 6.0
Polysorbate 20 5.9
ADR 5.8
Gadoteridol 5.8
VCR 5.8
Gliadel 5.7
more...
Enzyme
EC 5.99.1.1 11.8
topoisomerase 11.8
topoisomerase 11.6
hydroxypyruvate isomerase 9.2
RNase M5 8.0
kallikrein 10 8.0
S-formylglutathione hydrolase 6.9
nucleoside triphosphate phosphohydrolase 6.8
dCMP hydroxymethylase 6.5
endonuclease VII 6.1
DNA ligase 6.0
DNA ligase 6.0
P-glycoprotein 6.0
caspase-2 5.9
enzyme X 5.9
DNase II 5.8
caspase-2 5.8
lambda exonuclease 5.7
thymidylate synthase 5.6
polynucleotide kinase 5.5
MDR 5.5
AP lyase 5.5
ribonucleotide reductase 5.4
deoxycytidine deaminase 5.3
exonuclease V 5.3
dCMP deaminase 5.3
STK2 5.2
DNA polymerase 5.2
ribonucleotide reductase 5.1
deoxycytidine kinase 5.1
PIP kinase 5.1
dUTPase 5.1
PTR1 5.1
prolyl-tRNA synthetase 5.1
polo-like kinase 1 5.1
FabH 5.0
CPT 5.0
PARP 4.9
Escherichia coli exonuclease III 4.9
CPT 4.9
more...
Compound
N-ethylhydrazinecarbothioamide 11.8
Kinamycin C 11.8
C15H12O5 11.8
C15H12O5 11.8
8-Methoxycaffeine 11.8
C15H12O5 11.8
Podophyllotoxin acetate 11.8
C15H12O5 11.8
C15H12O5 11.8
C15H12O5 11.8
6-bromo-9H-purine 11.8
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.8
Psorospermin 11.3
Lunacridine 10.8
Lunacridine 10.8
5H-indeno[1,2-b]pyridin-5-one 10.8
C37H40N2O6 10.8
Albamycin 10.8
Methoxycamptothecin 10.8
2-butanone thiosemicarbazone 10.8
Usambarensine 10.8
Licodione 10.8
Mitindomide 10.8
m-AMSA 10.7
Merbarone 10.5
Elsamicin 10.4
C19H18O8 10.2
6-methoxy-5,8-quinolinedione 10.2
Voacamine 10.2
Fagaronine 10.0
benzo[a]phenazine 9.9
Fostriecin 9.9
CI-921 9.8
1-(phenylsulfonyl)-1H-indole 9.8
C17H20N2O3 9.8
Clorobiocin 9.8
ICRF-187 9.7
Chloroquinoxaline sulfonamide 9.4
Mulberrofuran G 9.4
11H-indeno[1,2-b]quinoline 9.4
more...