Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:5.99.1.2 (topoisomerase)
9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein DNA gyrase 1142 topoisomerase I 959 Mol 884 DNA topoisomerase 832 ATP 621 Sep 611 p53 368 P-glycoprotein 244 ATPase 227 DNA topoisomerase I 218 histone 189 TOP2A 183 helicase 182 MIC 176 thymus 159 topoisomerase II alpha 139 caspase-3 136 ICRF 124 endonuclease 118 NMR 117 polypeptide 117 DNA polymerase 111 PARP 104 p21 100 Bcl-2 99 H2AX 96 MLL 95 AML 93 ATM 87 telomeric 85 fused 84 Ki-67 77 DNase I 75 DNA-dependent protein kinase 70 TOP1 67 HER2 66 proteasome 66 poly(ADP-ribose) polymerase 66 Pseudomonas 65 ADP 63 more...

Disease cancer 2377 tumor 1054 leukemia 607 breast cancer 355 acute myeloid leukemia 250 carcinoma 202 MCF 186 lung cancer 164 ATM 129 vaccinia 129 lymphoma 122 myelodysplastic syndrome 117 adenocarcinoma 112 colon cancer 108 melanoma 102 ovarian cancer 99 lung carcinoma 89 BLM 87 CEM 82 acute lymphoblastic leukemia 81 carcinogenesis 80 non-small cell lung cancer 77 tumor growth 76 Leukemia 73 prostate cancer 73 hepatocellular carcinoma 73 small cell lung cancer 73 colorectal cancer 70 metastases 65 Mycobacterium 64 acute promyelocytic leukemia 57 tuberculosis 55 acute leukemia 53 tumorigenesis 53 HIV 53 SDS 52 glioma 50 PSS 50 neutropenia 47 neuroblastoma 44 more...

Symptom diarrhea 40 collapse 20 starvation 17 ataxia 14 dyspnea 10 nausea 10 vomiting 9 nausea and vomiting 8 fatigue 8 pain 7 seizures 6 headache 6 cough 4 ophthalmoplegia 4 abdominal pain 4 asthenia 4 HSA 3 weakness 3 anorexia 3 splenomegaly 3 apathy 2 menopausal symptoms 2 erythema 2 syncope 2 cerebellar ataxia 2 decreased appetite 2 chills 2 hyperoxia 2 hoarseness 1 night sweats 1 hepatomegaly 1 muscle stiffness 1 bone pain 1 No adverse effect 1 eds 1 Halo 1 hepatosplenomegaly 1 skin damage 1 exhaustion 1 hypoproteinemia 1 more...

Drug Etoposide 196 Adriamycin 111 CPT-11 93 DNase I 75 TTC 60 BLM 58 lysine 55 Irinotecan 41 caffeine 40 MDS 40 Mutagen 39 ADR 34 Asn 32 Dexrazoxane 27 ROS 26 Gel 18 Taxol 15 ampicillin 15 CTX 14 Gemifloxacin 13 Herceptin 13 Moxifloxacin 12 VCR 12 ABC 12 Glutathione 12 Teniposide 12 CTX 11 CTX 11 ADM 10 GEO 10 VCR 10 Docetaxel 10 Aclarubicin 9 AraC 9 MAP 9 Pixantrone 8 Dermatol 8 Idarubicin 7 Cardiovasc 7 Podophyllotoxin 7 more...

Enzyme topoisomerase 9166 topoisomerase 9094 P-glycoprotein 247 ATPase 232 DNA polymerase 174 protein kinase 140 RNA polymerase 138 ERK 130 PARP 120 endonuclease 118 caspase-3 101 mitogen-activated protein kinase 74 glutathione S-transferase 70 protein kinase C 68 proteasome 67 phosphodiesterase 66 MDR 57 DNA ligase 52 DNA ligase 52 thymidylate synthase 51 cdc2 42 luciferase 39 ACS 38 RNase 38 ribonucleotide reductase 37 RNase 34 reverse transcriptase 34 DNase 30 CPT 29 ribonucleotide reductase 29 CPT 29 CPT 29 peroxidase 27 dihydrofolate reductase 26 focal adhesion kinase 26 caspase-9 24 thymidine kinase 23 trypsin 22 catalase 22 caspase-8 21 more...

Compound DNA 5828 Dec 645 ATP 621 VP-16 469 m-AMSA 246 tyrosine 234 oxygen 220 Clin 205 Adriamycin 185 MIC 176 salt 163 VM-26 153 phosphate 147 hydrogen 130 sodium 119 MTT 118 acridine 113 ADR 112 water 110 serine 109 bromide 100 lysine 98 CPT-11 92 MDA 87 alanine 86 calcium 82 Camptothecin 81 Camptothecin 80 Camptothecin 80 nitrogen 77 SN-38 76 Mg2+ 76 Phe 73 arginine 72 sulfate 67 Asp 66 ADP 66 cysteine 64 ADP 63 ADP 63 more...

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