Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
shugoshin-like 2 11.8
TOP1mt 11.8
ubiquitin specific peptidase 42 11.8
DNA topoisomerase 11.8
LIX1L 11.8
ELOF1 11.8
Mariner transposase 11.8
type I DNA topoisomerase 11.6
ICB1 11.3
TOP2A protein 11.2
topo II beta 11.2
C9orf82 11.2
TOP1MT 11.2
DNA topoisomerase 1 11.1
DNA topoisomerase III 11.0
topoisomerase II beta 10.8
RMI2 10.8
CKBBP2 10.8
Type I DNA topoisomerase 10.8
dedicator of cytokinesis 10 10.8
PRRC1 10.8
SFRS7 10.8
RBP56/CHN 10.8
mitochondrial topoisomerase I 10.8
NLRP13 10.8
TOP2B 10.7
RMI1 10.7
topoisomerase II alpha 10.6
TOP3 10.6
TOP2 beta 10.4
TOP1 protein 10.4
TOP3A 10.4
ICRF 10.3
Tyrosyl-DNA phosphodiesterase 1 10.3
DNA gyrase 10.2
topoisomerase IIb 10.2
splicing factor 4 10.2
KIAA1210 10.2
MOZ/CBP 10.2
TDP1 protein 10.2
Mucosal vascular addressin cell adhesion molecule 1 10.2
TDRD3 10.2
MGC4175 10.2
TDP1 10.2
irs-2 10.2
TOP3B 10.0
TOP2A 10.0
PICH 9.9
topoisomerase I 9.8
tyrosyl-DNA phosphodiesterase 1 9.8
Tudor domain-containing protein 3 9.8
TOP1 9.7
DNA topoisomerase II beta 9.6
TRAF and TNF receptor-associated protein 9.6
FRYL 9.6
Mitotic kinesin-like protein 1 9.4
SNF2, histone-linker, PHD and RING finger domain-containing helicase 9.4
HZW10 9.4
ZNF214 9.4
SFRS4 9.4
ataxin 10 9.4
DNA topoisomerase 2 9.4
KIAA0020 9.4
DNA topoisomerase I 9.4
ICBP90 9.4
TTRAP 9.4
SPO11 9.3
SLFN11 9.3
TAFI110 9.2
PMX1 9.2
HXA3 9.2
Cys-X-Cys) 9.2
SARL 9.2
myeloid leukemia factor 2 9.2
E1A-like inhibitor of differentiation 3 9.2
MLL/AF4 fusion 9.2
TGGCA-binding protein 9.2
Ribosomal protein L3 9.0
SLC46A3 9.0
40S ribosomal protein S12 9.0
D10S102 8.8
BTBD12 8.8
PAK1IP1 8.8
PKCI-1 8.8
RANGAP1 8.8
BIN3 8.8
MX2 8.7
AML1/MDS1 8.7
Metnase 8.6
uridine phosphorylase 1 8.6
ALL-1 protein 8.6
MAK16 8.6
cell division cycle associated 8 8.6
Cyclin-dependent kinase 11 8.6
V-1 protein 8.6
cysteine dioxygenase type 1 8.4
BEN domain-containing protein 3 8.4
ZNF207 8.4
OTT-MAL 8.4
hCAP-C 8.4
rpl11 8.4
BLM protein 8.4
UBE3A protein 8.4
ICH-2 8.3
Histone acetyltransferase 1 8.3
TNF receptor-associated protein 8.3
USP42 8.3
APPBP2 8.3
ZNF451 8.3
ribonuclease H2 8.3
EME1 8.2
C-MYB 8.2
omega protein 8.2
arginyl-tRNA-protein transferase 8.2
B99 8.2
homeobox B5 8.2
CARD6 8.2
HRX 8.1
MUS81 8.1
PLGL 8.1
dihydropyrimidinase-like 2 8.1
RAD51-like 8.1
neural precursor cell expressed, developmentally down-regulated 8 8.1
HYAL-1 8.0
AD 3 8.0
budding uninhibited by benzimidazoles 1 8.0
SLD5 8.0
CAP-D2 8.0
meltrin beta 8.0
RNF41 8.0
PSF3 8.0
COX7B 8.0
hPMC2 8.0
RECQ5 8.0
beta2-chimaerin 7.9
ALL-1 7.9
multidrug resistance associated protein 7.9
PHRF1 7.9
CBF5 7.9
ZFM1 7.9
pck2 7.9
SGO2 7.9
Np95 7.8
PASK 7.8
MYM 7.8
ICH-1L 7.8
NCAPH 7.8
Bloom's syndrome protein 7.8
TRF4 7.7
NP95 7.7
SKI8 7.7
HSSB 7.7
dual specificity phosphatase 5 7.7
kinesin family member 20A 7.7
CGL-2 7.7
BAZ1A 7.7
GADD45G 7.6
TopBP1 7.6
p180 7.6
KIF4 7.6
RAD9A 7.6
TANC2 7.6
ubiquitin D 7.6
HPR1 7.6
cdc14 7.5
PGM5 7.5
cell division cycle associated 1 7.5
claudin 16 7.5
IARS 7.5
MDT1 7.5
Zhangfei 7.5
RDH11 7.5
retinoic acid-induced protein 7.5
RAD51-associated protein 1 7.5
RRN3 7.5
ATR-interacting protein 7.5
TIPIN 7.5
RP-A 7.5
RPA1 7.5
CELF4 7.4
POLA1 7.4
vacuolar H(+)-ATPase subunit 7.4
high mobility group 1 protein 7.4
TOP 7.4
HMGB4 7.4
ZYX 7.4
PSF2 7.4
C10orf2 7.4
PAPSS1 7.4
P1b 7.4
MDS1 7.4
Sur2 7.4
E2-EPF 7.4
CDK4I 7.4
PTPRE 7.4
USP16 7.4
single strand DNA-binding protein 7.4
MRX34 7.4
Tissue inhibitor of metalloproteinase 1 7.4
ATP-hydrolysing 7.3
HLA-DRB1*08 7.3
BLM 7.3
SAE2 7.3
BRIT1 7.3
aprt 7.3
granzyme H 7.3
EEN 7.3
DDX10 7.3
SHPRH 7.2
cell division cycle 20 7.2
KIN17 7.2
RAD51AP1 7.2
histidyl tRNA synthetase 7.2
RecQ5 7.2
MLP1 7.2
CTIP 7.2
RECQL5 7.2
MLL 7.2
p55CDC 7.2
Desmoglein-2 7.2
CtIP 7.2
DUSP9 7.1
RDH54 7.1
Tyrosine protein kinase 7.1
actopaxin 7.1
AF-4 7.1
Nuclear respiratory factor 1 7.1
CBF-B 7.1
SAF-A 7.1
glutathione S-transferase pi 7.1
multidrug resistance-related protein 7.1
maternal embryonic leucine zipper kinase 7.1
ZRANB3 7.1
ubiquitin protein ligase E3A 7.1
MER3 7.1
Tim13 7.1
And-1 7.1
U11/U12 7.1
p15 protein 7.1
P-glycoprotein 1 7.1
HELQ 7.1
MORC 7.0
RAD52 protein 7.0
RNASEH2B 7.0
EAP30 7.0
LRRFIP1 7.0
Translin 7.0
CYP2W1 7.0
AGGF1 7.0
Werner syndrome helicase 7.0
synaptonemal complex protein 1 7.0
SLC28A3 7.0
RAD6A 7.0
DNA helicase B 7.0
Btf 7.0
breakpoint cluster region 7.0
MLLT3 7.0
crn 7.0
ETO2 7.0
WRAP53 7.0
hBUB1 7.0
Bloom syndrome 7.0
cyclin B2 6.9
mdr1 6.9
SETMAR 6.9
XYLT2 6.9
inositol polyphosphate-5-phosphatase 6.9
wus 6.9
ZMYND8 6.9
70kD 6.9
AML2 6.9
L41 6.9
telomerase-associated protein 1 6.9
PTPRB 6.9
tripeptidyl-peptidase II 6.9
CDYL 6.9
AMPD3 6.9
WRN 6.9
RAD1 6.8
ML1 6.8
DNA polymerase theta 6.8
EDG-2 6.8
RBP56 6.8
HDAC4 protein 6.8
calpain-like protease 6.8
SMARCAD1 6.8
centromere protein F 6.8
ribosomal protein L41 6.8
germinal center-associated nuclear protein 6.8
caspase-activated DNase 6.8
DNA helicase 6.8
ADPRT 6.8
BUB1B 6.8
NSMCE2 6.8
CEBPG 6.8
putative E3 ubiquitin ligase 6.8
GE1 6.7
MRP 6.7
COM1 6.7
CDC7 6.7
SMC5 6.7
canalicular multispecific organic anion transporter 6.7
ribosomal protein L22 6.7
SMC2 6.7
NB-2 6.7
regulator of chromosome condensation 6.7
HD9 6.7
CDC23 6.7
MDR protein 6.7
HLA-DRB1*11 6.6
hypoxanthine phosphoribosyltransferase 1 6.6
UCHL3 6.6
PRKCE 6.6
RECQL1 6.6
Cyclin B2 6.6
DNA primase 6.6
POLQ 6.6
sensitive to apoptosis gene 6.6
haspin 6.6
RRM2B 6.6
more...
Disease
recurrent PNET 10.8
Therapy-related myelodysplastic syndrome 9.8
L.donovani 9.7
Teratoma with malignant transformation 9.2
SCAN1 8.3
mouse leukemia L1210 8.0
childhood ependymoma 8.0
PanIN-1A 7.6
PanIN-1B 7.5
secondary AML 7.3
Axonal Neuropathy 7.3
Drug resistant tuberculosis 7.2
secondary myelodysplastic syndromes 7.2
urogenital gonorrhea 7.1
de novo myelodysplastic syndromes 7.0
Shope fibroma 6.9
Idiopathic hypoparathyroidism 6.9
amok 6.7
BLM 6.6
FPD/AML 6.6
bacterial conjunctivitis 6.6
childhood ANLL 6.6
HER-2 positive breast cancer 6.5
adult soft tissue sarcoma 6.4
recurrent SCLC 6.3
Reovirus infection 6.3
AML/MDS 6.2
PanIN-2 6.2
mouse leukemia P388 6.2
preneoplastic state 6.1
limited-stage small cell lung cancer 6.1
Argininosuccinic aciduria 6.1
CEM 6.1
WRN 6.1
Anaplastic carcinoma 6.0
PanIN-3 5.9
MDS 5.8
Theileriosis 5.8
SMC 5.8
APL 5.8
Subependymomas 5.7
APL 5.7
MCPH1 5.7
TAS 5.6
microbial disease 5.6
Infection induced 5.6
CREST 5.6
MAR 5.6
FAB M2 5.4
ABC-DLBCL 5.4
vaccinia 5.4
metastatic pheochromocytoma 5.3
small cell lung cancer 5.3
Alpers 5.3
RAEB-T 5.2
Cerebral metastases 5.2
CNS cancer 5.2
RTS 5.2
squamous cell carcinoma of the anus 5.1
recurrent ovarian cancer 5.1
ATM 5.1
acute undifferentiated leukemia 5.1
in situ breast cancer 5.1
diffuse scleroderma 5.0
Gastrointestinal Tumor 5.0
histiocytic lymphoma 5.0
XPF 5.0
adenocarcinoma of unknown primary 5.0
ODA 4.9
APL 4.9
pediatric solid tumor 4.9
Brill 4.8
myeloid leukemia 4.8
mixed gliomas 4.8
Traveler's diarrhea 4.8
acute monocytic leukemia 4.8
PanIN 4.8
Enzyme inhibition 4.8
myelodysplastic syndrome 4.8
molluscum contagiosum 4.8
CPX 4.8
Photosensitized 4.7
AIDS-related lymphoma 4.7
RAEB 4.7
refractory cancer 4.7
adult AML 4.7
acute promyelocytic leukemia 4.7
cancer angiogenesis 4.6
recurrent cervical cancer 4.6
acute myeloid leukemia 4.6
FANCJ 4.6
histiocytic lymphoma 4.6
TAM 4.6
leukemogenesis 4.6
FA2 4.6
scleroderma 4.6
CHR 4.5
Malignant peripheral nerve sheath tumor 4.5
MCF 4.5
leukemia 4.5
uterine sarcoma 4.5
Staphylococcus aureus infection 4.5
refractory cytopenia with multilineage dysplasia 4.5
stage II breast cancer 4.5
lymphoblastoma 4.4
tonsillopharyngitis 4.4
HP1 4.4
African swine fever 4.4
indolent lymphoma 4.4
XPB 4.4
Fanconi 4.4
XPD 4.3
acute leukemia 4.3
lymphangiectasis 4.3
second cancer 4.3
RP4 4.3
HBT 4.3
Fanconi syndrome 4.2
lymphoblastic leukemia 4.2
adrenocortical cancer 4.2
FANCI 4.2
chronic enteritis 4.2
trisomy 9 4.2
testicular teratoma 4.2
chronic myelomonocytic leukemia 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
AT3 4.2
Chemoradiation 4.1
solid tumor 4.1
Drash syndrome 4.1
nagana 4.1
Sander 4.1
DRM 4.1
stage III colon cancer 4.1
Leukemia 4.1
xeroderma pigmentosum 4.1
Gull 4.0
Angelman syndrome 4.0
Seckel syndrome 4.0
lymphoid neoplasm 4.0
Malignant glioma 4.0
PSS 4.0
erythroleukemia 3.9
myelosuppression 3.9
AT/RT 3.9
microsporidiosis 3.9
XPG 3.9
stage IV NSCLC 3.9
metaplastic carcinoma 3.9
Spitz nevus 3.8
Salmonellosis 3.8
HIV encephalopathy 3.8
SAR 3.8
monocytic leukemia 3.8
pediatric brain tumor 3.8
pediatric AML 3.8
Larsen 3.8
IS3 3.8
Spinocerebellar ataxia 3.7
SME 3.7
primary disorders 3.7
metastatic gastric cancer 3.7
EMC 3.7
acute lymphoblastic leukemia 3.7
RSI 3.7
colon cancer 3.7
lung carcinoma 3.7
high-grade lymphomas 3.7
testicular cancer 3.7
MPGN 3.7
premature aging 3.7
metastatic neuroblastoma 3.6
acute cystitis 3.6
blast crisis 3.6
megakaryocytic leukemia 3.6
MRSA 3.6
ovarian cancer 3.6
evaluable disease 3.6
non-small cell lung cancer 3.6
DDP 3.5
orf 3.5
PML 3.5
NPHP1 3.5
cervical adenocarcinoma 3.5
BEN 3.5
childhood ALL 3.5
blood cancer 3.5
aggressive lymphoma 3.5
GCT 3.5
hormone refractory prostate cancer 3.5
epithelial tumor 3.4
Ovarian Cancer 3.4
Oral lichen planus 3.4
immunocytoma 3.4
invasive thymoma 3.4
Liposarcoma 3.4
trisomy 8 3.4
adenocarcinoma of the pancreas 3.4
metastatic neuroblastoma 3.4
Febrile neutropenia 3.4
smallpox 3.4
pneumonic plague 3.4
fibrosarcoma 3.4
CM1 3.4
high-grade squamous intraepithelial lesion 3.3
Vogt 3.3
uterine cancer 3.3
mastocytoma 3.3
epithelial ovarian cancer 3.3
VISA 3.3
metastatic ovarian cancer 3.3
sclerodactyly 3.3
adult ALL 3.3
HMR 3.3
African trypanosomiasis 3.2
Neuroblastoma 3.2
Neuroblastoma 3.2
neutropenia 3.2
stage III NSCLC 3.2
DMC 3.2
retinoblastoma 3.2
anal cancer 3.2
MTS 3.2
chronic leukemia 3.2
Robinson 3.2
DLBCL 3.2
neck cancer 3.2
Raynaud 3.1
PNET 3.1
CAN 3.1
squamous cell lung cancer 3.1
peritonsillar abscess 3.1
anal cancer 3.1
PDC 3.1
Ewing's sarcoma 3.1
AOA 3.1
renal clear cell carcinoma 3.1
glioblastoma 3.1
connective tissue disease 3.1
TCC 3.1
CIN II 3.0
paroxysmal tachycardia 3.0
platelet disorder 3.0
Mycoplasma 3.0
osteosarcoma 3.0
esophageal dysmotility 3.0
germ cell tumor 3.0
lung cancer 3.0
MRD 3.0
VPI 3.0
gastrointestinal dysfunction 3.0
keratocyst 3.0
severe congenital neutropenia 3.0
esthesioneuroblastoma 3.0
breast cancer 2.9
bends 2.9
MPE 2.9
cancer 2.9
MDM 2.9
Haemophilus 2.9
HTS 2.9
collagen disease 2.9
benign nevi 2.9
mammary tumor 2.9
LMS 2.9
childhood cancer 2.9
acute nonlymphocytic leukemia 2.9
PDB 2.8
Cholangiocarcinoma 2.8
sicca syndrome 2.8
myeloblastosis 2.8
leukopenia 2.8
testicular seminoma 2.8
neuromyotonia 2.8
leishmaniasis 2.8
renal cancer 2.8
pancytopenia 2.8
sarcoma 180 2.8
HML 2.8
ABL 2.8
adult T-cell leukemia/lymphoma 2.8
panuveitis 2.8
gynecologic cancer 2.8
adenocarcinoma of the lung 2.8
metastatic colon cancer 2.8
HGF 2.7
mantle cell lymphoma 2.7
multicentric Castleman's disease 2.7
L. infantum 2.7
metastatic breast cancer 2.7
gonococcal 2.7
Mendelian disorders 2.7
interstitial lung disease 2.7
comedo 2.7
ATD 2.7
EPI 2.7
collagen disease 2.7
Tropical Diseases 2.7
cervical squamous cell carcinoma 2.7
CTX 2.7
Osteosarcoma 2.7
Osteosarcoma 2.7
TBS 2.6
MTC 2.6
Ovary 2.6
hepatic coma 2.6
seborrheic keratosis 2.6
rhabdomyosarcoma 2.6
Condensation 2.6
lymphomatoid granulomatosis 2.6
hemophagocytic lymphohistiocytosis 2.6
adrenocortical carcinoma 2.6
NCR 2.6
more...
Symptom
disturbed balance 3.9
autodigestion 3.5
No adverse effect 3.4
Halo 2.9
decreased appetite 2.6
asthenia 2.4
menopausal symptoms 2.1
ophthalmoplegia 2.1
HSA 1.8
eds 1.7
hypoproteinemia 1.6
ataxia 1.6
night sweats 1.5
nausea and vomiting 1.5
muscle stiffness 1.5
tonic-clonic seizure 1.4
collapse 1.3
diarrhea 1.3
starvation 1.2
skin damage 1.2
incoordination 1.0
cerebellar ataxia 0.9
apathy 0.8
chills 0.7
rhinorrhea 0.6
nausea 0.6
dysuria 0.5
hyperoxia 0.4
dyspnea 0.3
hoarseness 0.2
bone pain 0.2
colic 0.1
splenomegaly 0.1
vomiting -0.0
hepatosplenomegaly -0.3
anorexia -0.4
syncope -0.4
paresthesia -0.5
hepatomegaly -0.7
hypotonia -0.8
cough -0.8
fatigue -0.9
erythema -0.9
abdominal pain -1.2
headache -1.4
weakness -1.9
sleepiness -1.9
seizures -1.9
functional recovery -2.0
exhaustion -2.0
discomfort -2.7
discomfort -2.8
pain -3.4
anesthesia -5.0
Drug
Sobuzoxane 11.2
Edotecarin 10.2
Premafloxacin 10.2
Pixantrone 9.7
Gemifloxacin mesylate 9.6
Etoposide 9.2
Aclarubicin 9.1
Dexrazoxane 9.1
Teniposide 8.8
Gemifloxacin 8.6
Sitafloxacin 8.4
Tetrahydropyran 8.2
Avelox 8.2
Ilmofosine 8.1
PZFX 8.0
Irofulven 7.8
Etoposide phosphate 7.5
1,2,4-Triazole 7.5
Podophyllotoxin 7.5
Irinotecan 7.4
CPT-11 7.4
Tirapazamine 7.3
Radicicol 7.3
BLM 7.2
Podophyllum 7.0
Idarubicin 6.9
Menogaril 6.8
TTC 6.8
Gatifloxacin 6.6
Moxifloxacin 6.5
Adriamycin 6.4
Tarivid 6.3
Gemzar 6.2
Epidoxorubicin 6.0
MDS 6.0
Polysorbate 20 5.9
ADR 5.8
Gadoteridol 5.8
VCR 5.8
Gliadel 5.7
Rauwolfia serpentina 5.7
Myricetin 5.5
Xeloda 5.5
Pentostam 5.4
Compound 9 5.4
Enrofloxacin 5.3
Dronedarone 5.3
Compound 19 5.3
Vorinostat 5.3
Taxotere 5.3
Navelbine 5.3
Pirarubicin 5.2
Compound 16 5.1
Vinorelbine 5.0
NOV 5.0
DNase I 5.0
Ofloxacin 4.9
Vindesine 4.9
AraC 4.9
Poudre 4.9
Vindesine 4.9
Compound 15 4.8
Zevalin 4.8
TEL 4.7
VCR 4.7
Mutagen 4.5
GEO 4.5
Atovaquone 4.4
Herceptin 4.3
Docetaxel 4.3
Filgrastim 4.3
CED 4.2
Pefloxacin 4.1
Novantrone 4.1
Filgrastim 4.1
Flavopiridol 4.1
Diamminedichloroplatinum 4.1
Taxol 4.0
Atovaquone 4.0
Fludarabine 3.9
Glucantime 3.9
Emodin 3.9
Swertia 3.9
Pyridoxal 3.7
Dihydro 3.7
KCL 3.7
ID2 3.6
Emodin 3.6
NovoSeven 3.5
Cremophor EL 3.5
ADM 3.5
CFS 3.4
DEL 3.4
Artesunate 3.3
Asn 3.2
Amifostine 3.2
Retinoic Acid 3.2
Gefitinib 3.1
Pemetrexed 3.1
MDM 3.1
EPI 3.0
Fluconazole 3.0
Lovastatin 3.0
Trifluoperazine 3.0
Glutathione 3.0
Photofrin 2.9
Bortezomib 2.8
Zoledronic acid 2.8
MTC 2.8
CTX 2.8
CTX 2.7
Ranitidine 2.7
FLP 2.7
ACT 2.7
caffeine 2.7
Doxycycline 2.7
Clofibrate 2.6
Meropenem 2.6
AMC 2.6
Dasatinib 2.5
CoCl2 2.5
CoCl2 2.5
R1881 2.5
Meropenem 2.5
ETS 2.4
AZT 2.4
Isotretinoin 2.4
Phosphatidylserine 2.4
Meth 2.4
Alanine 2.3
Gleevec 2.3
CTX 2.3
Paraffin 2.3
ABC 2.2
ROS 2.2
AZT 2.2
CDP 2.2
AGG 2.1
Zoledronic acid 2.1
TAC 2.1
Gel 2.1
Ouabain 2.1
MRC 2.0
Bevacizumab 2.0
NaI 1.9
NaI 1.9
NaI 1.9
NaI 1.9
Methylprednisolone 1.9
DEX 1.9
Oxaliplatin 1.9
Cetuximab 1.9
GRF 1.8
Itraconazole 1.8
-deoxyadenosine 1.7
G-CSF 1.7
CTC 1.7
lysine 1.7
G418 1.6
ampicillin 1.6
Fragment 1.6
L-tyrosine 1.5
RFP 1.5
Azithromycin 1.5
PCP 1.5
Vitamin B 1.5
DPA 1.5
Fraction 1.4
CTC 1.4
ZnCl2 1.4
ZnCl2 1.4
FeCl3 1.3
Vitamin K 1.3
IPM 1.2
Amiloride 1.2
balanced salt solution 1.2
DM1 1.1
Triclosan 1.1
MAP 1.0
Norplant 1.0
Amiloride 0.9
p75 0.8
Dakar 0.7
Imatinib 0.5
Forskolin 0.4
Fluorescein 0.4
Rituximab 0.3
CAM 0.3
MOF 0.2
IFN-beta 0.2
CaCl2 0.1
CaCl2 0.1
CaCl2 0.1
Retinoic acid 0.0
HCH 0.0
NH3 -0.0
Leaf -0.1
Fluorescein -0.1
ascorbate -0.1
Spectrum -0.2
Albumin -0.5
ICI -0.6
NADH -0.7
FAD -0.7
CSF -0.8
EPA -1.0
ROC -1.2
Spectrum -1.2
THF -1.2
lactose -1.3
IL-2 -1.5
citric acid -1.5
Monit -1.8
vitamin E -2.3
Nephron -2.4
Cardiovasc -3.0
IFN-gamma -3.1
Dermatol -3.2
Enzyme
topoisomerase 11.8
EC 5.99.1.1 11.8
topoisomerase 11.6
hydroxypyruvate isomerase 9.2
RNase M5 8.0
kallikrein 10 8.0
S-formylglutathione hydrolase 6.9
nucleoside triphosphate phosphohydrolase 6.8
dCMP hydroxymethylase 6.5
endonuclease VII 6.1
DNA ligase 6.0
DNA ligase 6.0
P-glycoprotein 6.0
caspase-2 5.9
enzyme X 5.9
DNase II 5.8
caspase-2 5.8
lambda exonuclease 5.7
thymidylate synthase 5.6
polynucleotide kinase 5.5
MDR 5.5
AP lyase 5.5
ribonucleotide reductase 5.4
deoxycytidine deaminase 5.3
exonuclease V 5.3
dCMP deaminase 5.3
STK2 5.2
DNA polymerase 5.2
ribonucleotide reductase 5.1
deoxycytidine kinase 5.1
PIP kinase 5.1
dUTPase 5.1
prolyl-tRNA synthetase 5.1
PTR1 5.1
polo-like kinase 1 5.1
FabH 5.0
CPT 5.0
PARP 4.9
Escherichia coli exonuclease III 4.9
CPT 4.9
DSR 4.9
amidophosphoribosyltransferase 4.8
glutamate racemase 4.8
penicillopepsin 4.8
endodeoxyribonuclease 4.7
micrococcal nuclease 4.6
Protein 2 4.6
deoxyguanosine kinase 4.6
inosine triphosphatase 4.5
endonuclease 4.5
CPT 4.5
pseudouridine synthase 4.4
alanine racemase 4.4
ubiquinol-cytochrome c oxidoreductase 4.4
enoyl-ACP reductase 4.4
separase 4.4
3'-phosphatase 4.4
enoyl-ACP reductase 4.3
ScpA 4.3
coproporphyrinogen III oxidase 4.3
RNase H 4.2
pyruvate formate-lyase 4.2
phosphatidylserine decarboxylase 4.1
cdc2 4.1
3'-exonuclease 4.1
acyl carrier protein synthase 4.1
aspartase 4.0
GM3 synthase 4.0
poly(A) polymerase 4.0
dihydrofolate reductase 4.0
IMP dehydrogenase 3.9
chitin synthase 3.9
branched-chain aminotransferase 3.9
NCP 3.8
deoxyribonuclease 3.8
peptide deformylase 3.8
prolidase 3.8
spermidine/spermine N1-acetyltransferase 3.8
caspase-6 3.8
RNA polymerase 3.8
coproporphyrinogen oxidase 3.8
DNase 3.8
DNA methyltransferase 3.7
dihydropteroate synthase 3.7
pyruvate oxidase 3.7
dihydropyrimidine dehydrogenase 3.7
pyruvate oxidase 3.7
proteinase K 3.7
nucleoside hydrolase 3.7
S1 nuclease 3.6
ATPase 3.6
phosphodiesterase 3.6
thymidylate kinase 3.6
caspase-7 3.5
carboxylesterase 3.5
MTD 3.5
LIS 3.5
caspase-7 3.5
cysteine synthase 3.5
caspase-9 3.5
caspase-1 3.5
penicillin binding protein 3.4
glutathione S-transferase 3.4
caspase-8 3.4
cytidine deaminase 3.4
thymidine kinase 3.4
NAT 3.4
orotate phosphoribosyltransferase 3.4
disulfide reductase 3.4
Fpg protein 3.4
thymidine phosphorylase 3.3
Lys4 3.3
tryptophanase 3.3
GCA 3.3
folylpolyglutamate synthetase 3.3
restriction-modification system 3.3
caspase-3 3.3
azoreductase 3.3
nicotinamide phosphoribosyltransferase 3.2
deoxyribonuclease 3.2
xylose isomerase 3.1
argininosuccinate lyase 3.1
caspase-4 3.1
dihydropyrimidine dehydrogenase 3.1
NQO1 3.1
choline oxidase 3.1
PST 3.1
dipeptidyl peptidase IV 3.1
hypoxanthine-guanine phosphoribosyltransferase 3.0
cruzipain 3.0
proteasome 3.0
tryptophan 2,3-dioxygenase 3.0
cyclohydrolase 3.0
venom phosphodiesterase 2.9
polyamine oxidase 2.9
Rex 2.9
TdT 2.9
RNase 2.9
histone demethylase 2.9
caspase-6 2.9
glucosylceramide synthase 2.9
RNase 2.9
matriptase 2.8
protein phosphatase 2A 2.8
farnesyltransferase 2.7
asparaginase 2.7
firefly luciferase 2.6
isopeptidase 2.6
protein kinase 2.6
CCS 2.6
TSA 2.5
thioredoxin reductase 2.5
lysyl oxidase 2.5
fumarate reductase 2.5
cathepsin L 2.4
phosphatidylinositol 4-kinase 2.4
PDH 2.4
histone acetyltransferase 2.3
adenine phosphoribosyltransferase 2.3
cathepsin B 2.3
kinesin 2.3
chaperonin 2.3
protein kinase C 2.3
transpeptidase 2.2
phosphoinositide 3-kinase 2.2
ERK 2.2
aldehyde oxidase 2.2
cytosine deaminase 2.2
farnesyltransferase 2.2
N-acetyltransferase 2.2
Alternating 2.2
peptidyl-prolyl cis-trans isomerase 2.1
demethylase 2.1
ubiquitin-protein ligase 2.1
MDH 2.1
histidine kinase 2.1
IKK 2.1
BAT 2.1
chloramphenicol acetyltransferase 2.0
MDH 2.0
PHD 2.0
sucrase-isomaltase 2.0
p100 2.0
sialidase 2.0
ornithine decarboxylase 1.9
Pla 1.9
CYP3A4 1.9
diaphorase 1.9
MAP 1.9
MEKK1 1.9
reverse transcriptase 1.9
phosphorylase 1.9
PRE 1.9
acyl-CoA oxidase 1.8
luciferase 1.8
formate dehydrogenase 1.8
formate dehydrogenase 1.8
PTPase 1.8
ADP-ribosyltransferase 1.8
C3 convertase 1.8
beta-galactosidase 1.7
ADP-ribosyltransferase 1.7
formate dehydrogenase 1.7
proprotein convertase 1.7
ribonuclease 1.7
ribonuclease 1.7
beta-lactamase 1.6
matrix metalloproteinase 2 1.6
ATP synthase 1.6
CD13 1.5
Thy1 1.5
PCP 1.5
CPS 1.5
cellulose synthase 1.5
mitogen-activated protein kinase 1.4
carboxypeptidase Y 1.4
cellobiohydrolase 1.4
BMT 1.4
glutathione reductase 1.4
cathepsin D 1.3
MMP 1.3
calcineurin 1.3
gamma-glutamylcysteine synthetase 1.3
TPP 1.3
MAT 1.2
carbonic anhydrase 1.2
tyrosinase 1.2
MEK 1.2
PNGase F 1.2
triphosphatase 1.2
beta-glucuronidase 1.2
isocitrate dehydrogenase 1.2
5'-nucleotidase 1.1
focal adhesion kinase 1.0
aldehyde dehydrogenase 1.0
isocitrate dehydrogenase 1.0
MAT 1.0
succinic dehydrogenase 1.0
aconitase 1.0
glycerol-3-phosphate dehydrogenase 1.0
cathepsin G 0.9
glycerol-3-phosphate dehydrogenase 0.9
prolyl hydroxylase 0.9
endoglycosidase H 0.9
phosphatidylinositol 3-kinase 0.9
phospholipase D 0.9
thermolysin 0.9
transcriptase 0.9
botulinum neurotoxin 0.9
trypsin 0.9
CaMKII 0.8
succinate dehydrogenase 0.8
ACS 0.7
AMPK 0.7
HIV-1 protease 0.7
NADH dehydrogenase 0.7
glyceraldehyde-3-phosphate dehydrogenase 0.7
chymotrypsin 0.7
CAD 0.7
aldehyde dehydrogenase 0.7
glyceraldehyde-3-phosphate dehydrogenase 0.7
aldehyde dehydrogenase 0.7
glutathione peroxidase 0.7
matrix metalloproteinase 9 0.7
CAD 0.7
aldehyde dehydrogenase 0.6
PDK1 0.6
GSK 0.6
CAD 0.6
malate dehydrogenase 0.6
hyaluronidase 0.6
alcohol dehydrogenase 0.6
APC 0.6
glyceraldehyde-3-phosphate dehydrogenase 0.6
neuraminidase 0.5
peroxidase 0.5
transglutaminase 0.5
lactate dehydrogenase 0.5
catalase 0.5
MDP 0.4
pyruvate dehydrogenase 0.3
glyceraldehyde-3-phosphate dehydrogenase 0.3
alkaline phosphatase 0.3
beta-glucosidase 0.3
acetyl-CoA carboxylase 0.3
diaphorase 0.2
complex I 0.2
hyaluronidase 0.2
thyroid peroxidase 0.2
furin 0.1
ricin 0.1
glyceraldehyde-3-phosphate dehydrogenase 0.1
aldehyde dehydrogenase 0.1
beta-glucosidase 0.1
granzyme B 0.1
UDP-glucuronosyltransferase 0.1
pyruvate dehydrogenase -0.0
prostate-specific antigen -0.0
pyruvate dehydrogenase -0.0
nitrogenase -0.1
NOS -0.1
enolase -0.1
NADPH oxidase -0.1
phosphofructokinase -0.1
glucose-6-phosphate dehydrogenase -0.2
NADPH-diaphorase -0.2
neutrophil elastase -0.2
heme oxygenase -0.3
chitinase -0.3
lipoxygenase -0.3
glutamate dehydrogenase -0.3
glutamate dehydrogenase -0.3
subtilisin -0.3
cytochrome oxidase -0.3
PAH -0.3
glutamate dehydrogenase -0.4
citrate synthase -0.4
plasmin -0.4
creatine kinase -0.4
acetylcholinesterase -0.4
more...
Compound
8-Methoxycaffeine 11.8
Podophyllotoxin acetate 11.8
Kinamycin C 11.8
C15H12O5 11.8
N-ethylhydrazinecarbothioamide 11.8
6-bromo-9H-purine 11.8
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.8
C15H12O5 11.8
C15H12O5 11.8
C15H12O5 11.8
C15H12O5 11.8
C15H12O5 11.8
Psorospermin 11.3
2-butanone thiosemicarbazone 10.8
5H-indeno[1,2-b]pyridin-5-one 10.8
Albamycin 10.8
Methoxycamptothecin 10.8
Mitindomide 10.8
Usambarensine 10.8
Lunacridine 10.8
Licodione 10.8
C37H40N2O6 10.8
Lunacridine 10.8
m-AMSA 10.7
Merbarone 10.5
Elsamicin 10.4
6-methoxy-5,8-quinolinedione 10.2
Voacamine 10.2
C19H18O8 10.2
Fagaronine 10.0
benzo[a]phenazine 9.9
Fostriecin 9.9
CI-921 9.8
1-(phenylsulfonyl)-1H-indole 9.8
Clorobiocin 9.8
C17H20N2O3 9.8
ICRF-187 9.7
11H-indeno[1,2-b]quinoline 9.4
Moxifloxacin hydrochloride 9.4
Chloroquinoxaline sulfonamide 9.4
Methanesulfonanilide 9.4
11H-indeno[1,2-b]quinoline 9.4
2,6-piperazinedione 9.4
Mulberrofuran G 9.4
benzo[i]phenanthridine 9.4
Ellipticine 9.4
Novobiocin 9.3
VM-26 9.3
9-cis-Retinal 9.2
Bimolane 9.2
2-hydroxynaphthoquinone 9.2
C14H12O3 9.2
Cryptolepine 9.1
2-hydroxynaphthoquinone 9.1
VP-16 9.0
2,3-dihydro-1H-cyclopenta[b]quinoline 9.0
Pinobanksin 9.0
Rubrofusarin 9.0
Topotecan 8.9
Camptothecin 8.9
Camptothecin 8.9
Camptothecin 8.9
beta-Lapachone 8.9
C18H18N2O5 8.8
Illudin S 8.7
benzo[g]isoquinoline-5,10-dione 8.6
[1,2,4]triazolo[1,5-a]pyridine 8.6
NMHE 8.6
1-methyl-4-piperidinol 8.6
Toxoflavin 8.4
Nogalamycin 8.4
5,11-dimethyl-6H-pyrido[4,3-b]carbazole 8.4
Sitafloxacin 8.4
Topotecan 8.4
6H-indolo[2,3-b]quinoxaline 8.3
Quinalizarin 8.3
Diospyrin 8.3
Wedelolactone 8.3
Cyasorb 8.3
Rebeccamycin 8.2
Naringenin chalcone 8.2
9-chloroacridine 8.2
Butin 8.2
CI-941 8.1
Petroselinic acid 8.1
Cubebin 8.0
Piperlonguminine 8.0
Coumermycin 7.9
SN-38 7.9
delta12,14-PGJ2 7.9
A 186 7.9
Lucanthone 7.8
Bulbocapnine 7.8
Chartreusin 7.7
Ametantrone 7.7
Salicylaldoxime 7.7
Deoxydoxorubicin 7.6
Mitoxantrone 7.6
Podophyllotoxin 7.5
benzo[c]phenanthridine 7.5
Amarogentin 7.5
Xanthatin 7.5
Isofraxidin 7.5
Nalidixic acid 7.5
Podophyllotoxin 7.5
Mitoxantrone 7.5
5-Formyluracil 7.4
1,3-thiazolidine-2-thione 7.4
CPT-11 7.4
Amonafide 7.4
2-phenylnaphthalene 7.4
Fraxetin 7.3
5-Hydroxymethyluracil 7.3
Trovafloxacin 7.3
ICRF 159 7.3
ICRF 159 7.2
Isometamidium chloride 7.2
2-(4-morpholinyl)ethyl 7.2
ICRF 159 7.2
4(1H)-quinolinone 7.2
Cuminaldehyde 7.2
1,3-thiazolidine-2-thione 7.2
2-(4-morpholinyl)ethyl 7.1
Xanthatin 7.1
Azidopine 7.1
I acid 7.1
3-fluoropyridine 7.1
7-oxabicyclo[2.2.1]heptane 7.1
2-(dimethylamino)ethyl 7.0
2-(dimethylamino)ethyl 7.0
Liriodenine 7.0
Solamargine 7.0
Danthron 7.0
Hoechst dye 33258 7.0
Cucurbitacin I 7.0
2,5-dihydroxyterephthalic acid 7.0
hydrazinecarbothioamide 7.0
1,2,4-benzenetriol 6.9
2-ethoxy-2-oxoethyl 6.9
9-AC 6.9
1H-benzo[de]isoquinoline-1,3(2H)-dione 6.9
1,4-dihydronaphthalene 6.8
Imexon 6.8
2-amino-1-propanol 6.8
Citronellal 6.8
R-11 6.8
1H-indole-3-carbaldehyde 6.7
3-quinolinecarboxylic acid 6.7
Aphidicolin 6.7
Aphidicolin 6.7
Gatifloxacin 6.7
Acridone 6.6
Niguldipine 6.6
Moxifloxacin 6.5
Dibromodulcitol 6.5
Distamycin A 6.5
stigmast-4-en-3-one 6.5
Vinca 6.4
Novex 6.4
1-methylpiperazine 6.4
Harmine 6.4
C14H12N2 6.4
Digitoxin 6.4
Genistin 6.4
Fludarabine phosphate 6.4
2-pyridinecarboxylic acid 6.4
Nitidine 6.3
Berenil 6.3
Adriamycin 6.3
Genistein 6.3
N-phenylbenzamide 6.2
BLM 6.2
3-chloropyridine 6.1
Tiazofurin 6.1
Myricitrin 6.1
Methyleugenol 6.1
3-aminobenzamide 6.1
BNS 6.1
Phorbol-12,13-dibutyrate 6.1
ethyl propiolate 6.1
Samorin 6.1
Oxolinic acid 6.0
Buthionine sulfoximine 6.0
phenanthridine 6.0
phenanthridine 6.0
phenanthridine 6.0
ADR 6.0
Daunorubicin 6.0
9AA 5.9
Epirubicin 5.9
9AA 5.9
Diamminedichloroplatinum 5.9
Echinomycin 5.9
Grepafloxacin 5.9
Ethidium bromide 5.9
Ciprofloxacin 5.9
HMBA 5.9
4H-pyrido[1,2-a]pyrimidin-4-one 5.9
acridine 5.8
Norfloxacin 5.7
Eriochrome Black T 5.7
2-Aminopurine 5.7
Carnosol 5.7
WR-1065 5.7
PALA 5.7
6-Thioguanine 5.7
Levofloxacin 5.7
Lycorine 5.7
[1,10]phenanthroline 5.7
B17 5.7
LNT 5.7
Acetophenone 5.7
Garcinol 5.7
DVC 5.6
Nedaplatin 5.6
Lomefloxacin 5.6
3-hydroxyaspartic acid 5.6
PRPP 5.6
Flubendazole 5.6
Betulinic acid 5.5
Bufalin 5.5
DEK 5.5
Butein 5.4
HMBA 5.4
methanesulfonamide 5.4
XTP 5.4
D-Galactosamine 5.4
methanesulfonamide 5.4
D-Glyceraldehyde 5.4
2-methylquinoline 5.4
Isoliquiritigenin 5.4
N-ethylurea 5.4
Anthraquinone 5.4
Pentamidine 5.4
selenourea 5.4
Deoxyguanosine 5.4
6-aminonicotinamide 5.3
MDR 5.3
[1,10]phenanthroline 5.3
dATP 5.3
cyclopentanol 5.3
Enoxacin 5.3
Homoharringtonine 5.2
TCH 5.2
aceturate 5.2
SC-1 5.2
2-methylquinoline 5.2
SC-1 5.2
Propoxur 5.2
Sparfloxacin 5.1
Coumestrol 5.1
Flavone 5.1
1,2,4-benzotriazine 5.1
cinnoline 5.1
Ofloxacin 5.1
Hoechst 33342 5.1
2,6-dimethylpyridine 5.1
tris(2-chloroethyl) phosphate 5.1
Potassium permanganate 5.1
bis(2-chloroethyl) 5.0
STP 5.0
ADP-ribose 5.0
TSC 5.0
2-hydroxy-1-naphthaldehyde 5.0
2-hydroxy-1-naphthaldehyde 5.0
2-hydroxy-1-naphthaldehyde 5.0
Aloe-emodin 5.0
Glyoxylate 5.0
Quinacrine 5.0
2-hydroxy-1-naphthaldehyde 5.0
2-hydroxy-1-naphthaldehyde 5.0
CPT 5.0
Herbimycin 5.0
Celastrol 5.0
Chloroacetaldehyde 5.0
CPT 5.0
bis(2-chloroethyl) 5.0
Plumbagin 4.9
naphthoquinone 4.9
naphthoquinone 4.9
naphthoquinone 4.9
naphthoquinone 4.9
naphthoquinone 4.9
ETH 4.9
methyl methanesulfonate 4.9
1H-benzimidazole 4.9
naphthoquinone 4.9
2-hydroxy-1-naphthaldehyde 4.9
Quinone 4.9
2-hydroxy-1-naphthaldehyde 4.9
Thiazolidinedione 4.9
Daidzein 4.9
3,4-dihydroxybenzaldehyde 4.9
MIC 4.9
ATC 4.8
1H-pyrrole 4.8
Phosphoserine 4.8
naphthoquinone 4.8
1H-pyrrole 4.8
Z-Gly 4.8
myricetin 4.8
Fisetin 4.8
ATC 4.8
Cinnamaldehyde 4.8
Suramin 4.8
9H-xanthen-9-one 4.8
sedoheptulose 7-phosphate 4.7
Usnic acid 4.7
TEL 4.7
Gambogic acid 4.7
celastrol 4.7
8-MOP 4.7
chalcone 4.7
AZQ 4.7
Prodigiosin 4.7
Quinacrine 4.7
Lithocholic acid 4.7
Prodigiosin 4.7
DAU 4.7
BON 4.7
more...