Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ubiquitin specific peptidase 42 11.8
shugoshin-like 2 11.8
DNA topoisomerase 11.8
ELOF1 11.8
Mariner transposase 11.8
LIX1L 11.8
TOP1mt 11.8
type I DNA topoisomerase 11.6
ICB1 11.3
TOP2A protein 11.2
C9orf82 11.2
TOP1MT 11.2
topo II beta 11.2
DNA topoisomerase 1 11.1
DNA topoisomerase III 11.0
topoisomerase II beta 10.8
RBP56/CHN 10.8
dedicator of cytokinesis 10 10.8
NLRP13 10.8
SFRS7 10.8
more...
Disease
recurrent PNET 10.8
Therapy-related myelodysplastic syndrome 9.8
L.donovani 9.7
Teratoma with malignant transformation 9.2
SCAN1 8.3
mouse leukemia L1210 8.0
childhood ependymoma 8.0
PanIN-1A 7.6
PanIN-1B 7.5
secondary AML 7.3
Axonal Neuropathy 7.3
Drug resistant tuberculosis 7.2
secondary myelodysplastic syndromes 7.2
urogenital gonorrhea 7.1
de novo myelodysplastic syndromes 7.0
Idiopathic hypoparathyroidism 6.9
Shope fibroma 6.9
amok 6.7
BLM 6.6
FPD/AML 6.6
more...
Symptom
disturbed balance 3.9
autodigestion 3.5
No adverse effect 3.4
Halo 2.9
decreased appetite 2.6
asthenia 2.4
menopausal symptoms 2.1
ophthalmoplegia 2.1
HSA 1.8
eds 1.7
hypoproteinemia 1.6
ataxia 1.6
night sweats 1.5
nausea and vomiting 1.5
muscle stiffness 1.5
tonic-clonic seizure 1.4
collapse 1.3
diarrhea 1.3
starvation 1.2
skin damage 1.2
more...
Drug
Sobuzoxane 11.2
Edotecarin 10.2
Premafloxacin 10.2
Pixantrone 9.7
Gemifloxacin mesylate 9.6
Etoposide 9.2
Aclarubicin 9.1
Dexrazoxane 9.1
Teniposide 8.8
Gemifloxacin 8.6
Sitafloxacin 8.4
Avelox 8.2
Tetrahydropyran 8.2
Ilmofosine 8.1
PZFX 8.0
Irofulven 7.8
Etoposide phosphate 7.5
1,2,4-Triazole 7.5
Podophyllotoxin 7.5
Irinotecan 7.4
more...
Enzyme
EC 5.99.1.1 11.8
topoisomerase 11.8
topoisomerase 11.6
hydroxypyruvate isomerase 9.2
RNase M5 8.0
kallikrein 10 8.0
S-formylglutathione hydrolase 6.9
nucleoside triphosphate phosphohydrolase 6.8
dCMP hydroxymethylase 6.5
endonuclease VII 6.1
DNA ligase 6.0
DNA ligase 6.0
P-glycoprotein 6.0
caspase-2 5.9
enzyme X 5.9
DNase II 5.8
caspase-2 5.8
lambda exonuclease 5.7
thymidylate synthase 5.6
polynucleotide kinase 5.5
more...
Compound
N-ethylhydrazinecarbothioamide 11.8
C15H12O5 11.8
C15H12O5 11.8
Kinamycin C 11.8
6-bromo-9H-purine 11.8
C15H12O5 11.8
C15H12O5 11.8
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 11.8
8-Methoxycaffeine 11.8
C15H12O5 11.8
C15H12O5 11.8
Podophyllotoxin acetate 11.8
Psorospermin 11.3
Lunacridine 10.8
C37H40N2O6 10.8
Licodione 10.8
Methoxycamptothecin 10.8
Albamycin 10.8
Usambarensine 10.8
5H-indeno[1,2-b]pyridin-5-one 10.8
more...