Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA gyrase 1142
topoisomerase I 959
Mol 884
DNA topoisomerase 832
ATP 621
Sep 611
p53 368
P-glycoprotein 244
ATPase 227
DNA topoisomerase I 218
histone 189
TOP2A 183
helicase 182
MIC 176
thymus 159
topoisomerase II alpha 139
caspase-3 136
ICRF 124
endonuclease 118
NMR 117
more...
Disease
cancer 2377
tumor 1054
leukemia 607
breast cancer 355
acute myeloid leukemia 250
carcinoma 202
MCF 186
lung cancer 164
ATM 129
vaccinia 129
lymphoma 122
myelodysplastic syndrome 117
adenocarcinoma 112
colon cancer 108
melanoma 102
ovarian cancer 99
lung carcinoma 89
BLM 87
CEM 82
acute lymphoblastic leukemia 81
more...
Symptom
diarrhea 40
collapse 20
starvation 17
ataxia 14
nausea 10
dyspnea 10
vomiting 9
nausea and vomiting 8
fatigue 8
pain 7
seizures 6
headache 6
abdominal pain 4
cough 4
ophthalmoplegia 4
asthenia 4
HSA 3
anorexia 3
weakness 3
splenomegaly 3
more...
Drug
Etoposide 196
Adriamycin 111
CPT-11 93
DNase I 75
TTC 60
BLM 58
lysine 55
Irinotecan 41
caffeine 40
MDS 40
Mutagen 39
ADR 34
Asn 32
Dexrazoxane 27
ROS 26
Gel 18
Taxol 15
ampicillin 15
CTX 14
Herceptin 13
more...
Enzyme
topoisomerase 9166
topoisomerase 9094
P-glycoprotein 247
ATPase 232
DNA polymerase 174
protein kinase 140
RNA polymerase 138
ERK 130
PARP 120
endonuclease 118
caspase-3 101
mitogen-activated protein kinase 74
glutathione S-transferase 70
protein kinase C 68
proteasome 67
phosphodiesterase 66
MDR 57
DNA ligase 52
DNA ligase 52
thymidylate synthase 51
more...
Compound
DNA 5828
Dec 645
ATP 621
VP-16 469
m-AMSA 246
tyrosine 234
oxygen 220
Clin 205
Adriamycin 185
MIC 176
salt 163
VM-26 153
phosphate 147
hydrogen 130
sodium 119
MTT 118
acridine 113
ADR 112
water 110
serine 109
more...