Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA topoisomerase 0.091
DNA gyrase 0.042
topoisomerase I 0.027
topoisomerase II alpha 0.007
TOP2A 0.006
type I DNA topoisomerase 0.005
ICRF 0.005
DNA topoisomerase I 0.005
DNA topoisomerase 1 0.004
topoisomerase II beta 0.002
RMI1 0.002
TOP1 0.002
TOP2B 0.002
topo II beta 0.001
DNA topoisomerase III 0.001
TOP3 0.001
TDP1 0.001
RMI2 0.001
TOP2A protein 0.001
Tyrosyl-DNA phosphodiesterase 1 0.001
tyrosyl-DNA phosphodiesterase 1 0.001
TOP1mt 0.001
TOP1MT 0.001
SPO11 0.001
ICB1 0.001
MX2 0.001
P-glycoprotein 0.000
mitochondrial topoisomerase I 0.000
MLL 0.000
helicase 0.000
TOP3A 0.000
PICH 0.000
TOP3B 0.000
ATP 0.000
BLM 0.000
H2AX 0.000
Mariner transposase 0.000
DNA helicase 0.000
C9orf82 0.000
p53 0.000
DNA-dependent protein kinase 0.000
ICBP90 0.000
mdr1 0.000
MIC 0.000
TOP 0.000
SLFN11 0.000
ATM 0.000
ELOF1 0.000
LIX1L 0.000
shugoshin-like 2 0.000
ubiquitin specific peptidase 42 0.000
TOP1 protein 0.000
TTRAP 0.000
TOP2 beta 0.000
DNA polymerase alpha 0.000
Mol 0.000
Chk1 0.000
MRP 0.000
AML 0.000
irs-2 0.000
TDRD3 0.000
MUS81 0.000
DNA polymerase 0.000
PARP 0.000
SFRS7 0.000
CKBBP2 0.000
Type I DNA topoisomerase 0.000
dedicator of cytokinesis 10 0.000
RBP56/CHN 0.000
PRRC1 0.000
NLRP13 0.000
breakpoint cluster region 0.000
poly(ADP-ribose) polymerase 0.000
MDR1 0.000
DNA topoisomerase 2 0.000
Chk2 0.000
Tudor domain-containing protein 3 0.000
DNA ligase 0.000
ATPase 0.000
multidrug resistance associated protein 0.000
EME1 0.000
TopBP1 0.000
TRAF and TNF receptor-associated protein 0.000
DNA topoisomerase II beta 0.000
FRYL 0.000
histone 0.000
KIAA1210 0.000
splicing factor 4 0.000
MGC4175 0.000
Mucosal vascular addressin cell adhesion molecule 1 0.000
TDP1 protein 0.000
MOZ/CBP 0.000
topoisomerase IIb 0.000
WRN 0.000
HRX 0.000
Metnase 0.000
endonuclease 0.000
MDS 0.000
BLM protein 0.000
ALL-1 0.000
thymidylate synthase 0.000
DNase I 0.000
Bloom syndrome 0.000
thymus 0.000
P1b 0.000
Rad50 0.000
ataxia telangiectasia mutated 0.000
AML1 0.000
p180 0.000
CtIP 0.000
ADR 0.000
multidrug resistance-associated protein 0.000
ABCC1 0.000
Mitotic kinesin-like protein 1 0.000
ataxin 10 0.000
ZNF214 0.000
SFRS4 0.000
SNF2, histone-linker, PHD and RING finger domain-containing helicase 0.000
HZW10 0.000
KIAA0020 0.000
Ki-67 0.000
PAK1IP1 0.000
SARL 0.000
myeloid leukemia factor 2 0.000
PMX1 0.000
TGGCA-binding protein 0.000
HXA3 0.000
Cys-X-Cys) 0.000
E1A-like inhibitor of differentiation 3 0.000
TAFI110 0.000
MLL/AF4 fusion 0.000
LRP 0.000
p21 0.000
ATR 0.000
AML1/MDS1 0.000
RPA1 0.000
telomeric 0.000
SLC46A3 0.000
40S ribosomal protein S12 0.000
Ribosomal protein L3 0.000
RAD51 0.000
A-T 0.000
colon carcinoma 0.000
caspase-3 0.000
MRE11 0.000
alpha isoform 0.000
Rad51 0.000
PKCI-1 0.000
BIN3 0.000
BTBD12 0.000
RANGAP1 0.000
D10S102 0.000
DNA primase 0.000
UBE3A protein 0.000
TNF receptor-associated protein 0.000
histone H1 0.000
uridine phosphorylase 1 0.000
Cyclin-dependent kinase 11 0.000
MAK16 0.000
cell division cycle associated 8 0.000
more...
Disease
cancer 0.001
leukemia 0.000
BLM 0.000
Therapy-related myelodysplastic syndrome 0.000
acute myeloid leukemia 0.000
CEM 0.000
tumor 0.000
vaccinia 0.000
L.donovani 0.000
secondary AML 0.000
ATM 0.000
MCF 0.000
recurrent PNET 0.000
mouse leukemia L1210 0.000
myelodysplastic syndrome 0.000
WRN 0.000
small cell lung cancer 0.000
breast cancer 0.000
MDS 0.000
Teratoma with malignant transformation 0.000
SCAN1 0.000
acute promyelocytic leukemia 0.000
colon cancer 0.000
lung cancer 0.000
Leukemia 0.000
ovarian cancer 0.000
lung carcinoma 0.000
acute leukemia 0.000
SMC 0.000
acute lymphoblastic leukemia 0.000
scleroderma 0.000
myeloid leukemia 0.000
carcinoma 0.000
non-small cell lung cancer 0.000
childhood ependymoma 0.000
TAS 0.000
Shope fibroma 0.000
PSS 0.000
APL 0.000
APL 0.000
lymphoma 0.000
leukemogenesis 0.000
bacterial conjunctivitis 0.000
solid tumor 0.000
PanIN-1A 0.000
MAR 0.000
PanIN-1B 0.000
adenocarcinoma 0.000
CREST 0.000
Axonal Neuropathy 0.000
Drug resistant tuberculosis 0.000
Fanconi 0.000
secondary myelodysplastic syndromes 0.000
melanoma 0.000
urogenital gonorrhea 0.000
de novo myelodysplastic syndromes 0.000
AML/MDS 0.000
neutropenia 0.000
SAR 0.000
lymphoblastic leukemia 0.000
Idiopathic hypoparathyroidism 0.000
myelosuppression 0.000
APL 0.000
TAM 0.000
amok 0.000
glioblastoma 0.000
FPD/AML 0.000
RTS 0.000
childhood ANLL 0.000
carcinogenesis 0.000
tumor growth 0.000
epithelial ovarian cancer 0.000
HER-2 positive breast cancer 0.000
adult soft tissue sarcoma 0.000
colorectal cancer 0.000
histiocytic lymphoma 0.000
prostate cancer 0.000
osteosarcoma 0.000
erythroleukemia 0.000
limited-stage small cell lung cancer 0.000
recurrent SCLC 0.000
Reovirus infection 0.000
histiocytic lymphoma 0.000
glioma 0.000
Mycoplasma 0.000
PanIN-2 0.000
recurrent ovarian cancer 0.000
retinoblastoma 0.000
Mycobacterium 0.000
mouse leukemia P388 0.000
African swine fever 0.000
preneoplastic state 0.000
xeroderma pigmentosum 0.000
hepatocellular carcinoma 0.000
Argininosuccinic aciduria 0.000
Haemophilus 0.000
acute monocytic leukemia 0.000
neuroblastoma 0.000
fibrosarcoma 0.000
Anaplastic carcinoma 0.000
PanIN-3 0.000
MRSA 0.000
DDP 0.000
XPF 0.000
MCPH1 0.000
sarcoma 0.000
molluscum contagiosum 0.000
Theileriosis 0.000
Klebsiella 0.000
Fanconi syndrome 0.000
Subependymomas 0.000
Staphylococcus aureus infection 0.000
CNS cancer 0.000
leishmaniasis 0.000
SDS 0.000
microbial disease 0.000
Infection induced 0.000
RAEB 0.000
PML 0.000
testicular cancer 0.000
tumorigenesis 0.000
diffuse scleroderma 0.000
HP1 0.000
Alpers 0.000
RAEB-T 0.000
FAB M2 0.000
ABC-DLBCL 0.000
chronic myelomonocytic leukemia 0.000
adult AML 0.000
metastatic pheochromocytoma 0.000
multiple myeloma 0.000
cervical cancer 0.000
acute undifferentiated leukemia 0.000
thrombocytopenia 0.000
Cerebral metastases 0.000
GSH 0.000
XPD 0.000
metastases 0.000
tuberculosis 0.000
second cancer 0.000
blast crisis 0.000
ODA 0.000
squamous cell carcinoma of the anus 0.000
in situ breast cancer 0.000
Gastrointestinal Tumor 0.000
premature aging 0.000
smallpox 0.000
CHR 0.000
adenocarcinoma of unknown primary 0.000
Enzyme inhibition 0.000
Malignant peripheral nerve sheath tumor 0.000
Ewing's sarcoma 0.000
RP4 0.000
CPX 0.000
leukopenia 0.000
uterine sarcoma 0.000
mammary tumor 0.000
Angelman syndrome 0.000
pediatric solid tumor 0.000
PDB 0.000
more...
Symptom
diarrhea 0.000
disturbed balance 0.000
collapse 0.000
ataxia 0.000
starvation 0.000
autodigestion 0.000
No adverse effect 0.000
asthenia 0.000
Halo 0.000
nausea and vomiting 0.000
decreased appetite 0.000
ophthalmoplegia 0.000
menopausal symptoms 0.000
HSA 0.000
nausea 0.000
dyspnea 0.000
eds 0.000
hypoproteinemia 0.000
night sweats 0.000
muscle stiffness 0.000
vomiting 0.000
tonic-clonic seizure 0.000
skin damage 0.000
cerebellar ataxia 0.000
incoordination 0.000
apathy 0.000
chills 0.000
rhinorrhea 0.000
hyperoxia 0.000
dysuria 0.000
splenomegaly 0.000
fatigue 0.000
hoarseness 0.000
bone pain 0.000
colic 0.000
anorexia 0.000
cough 0.000
syncope 0.000
hepatosplenomegaly 0.000
headache 0.000
paresthesia 0.000
abdominal pain 0.000
hepatomegaly 0.000
erythema 0.000
hypotonia 0.000
seizures 0.000
weakness 0.000
sleepiness 0.000
functional recovery 0.000
exhaustion 0.000
pain 0.000
discomfort 0.000
discomfort 0.000
anesthesia 0.000
Drug
Etoposide 0.004
CPT-11 0.001
Dexrazoxane 0.001
Sobuzoxane 0.000
Adriamycin 0.000
BLM 0.000
Pixantrone 0.000
Irinotecan 0.000
TTC 0.000
Teniposide 0.000
Aclarubicin 0.000
Gemifloxacin 0.000
Gemifloxacin mesylate 0.000
Edotecarin 0.000
Premafloxacin 0.000
Sitafloxacin 0.000
MDS 0.000
DNase I 0.000
ADR 0.000
Podophyllotoxin 0.000
Moxifloxacin 0.000
Avelox 0.000
Idarubicin 0.000
Podophyllum 0.000
Tetrahydropyran 0.000
Tirapazamine 0.000
Irofulven 0.000
Mutagen 0.000
Ilmofosine 0.000
PZFX 0.000
Radicicol 0.000
Gatifloxacin 0.000
VCR 0.000
1,2,4-Triazole 0.000
Etoposide phosphate 0.000
Gemzar 0.000
Menogaril 0.000
VCR 0.000
Taxotere 0.000
AraC 0.000
Asn 0.000
Herceptin 0.000
Tarivid 0.000
Myricetin 0.000
Taxol 0.000
Ofloxacin 0.000
caffeine 0.000
GEO 0.000
Enrofloxacin 0.000
Epidoxorubicin 0.000
Vorinostat 0.000
Docetaxel 0.000
Polysorbate 20 0.000
Compound 9 0.000
TEL 0.000
Gadoteridol 0.000
Gliadel 0.000
Rauwolfia serpentina 0.000
Vinorelbine 0.000
Xeloda 0.000
Pentostam 0.000
lysine 0.000
Dronedarone 0.000
Navelbine 0.000
Compound 19 0.000
Pirarubicin 0.000
NOV 0.000
ADM 0.000
ROS 0.000
Compound 16 0.000
Vindesine 0.000
Poudre 0.000
Vindesine 0.000
Compound 15 0.000
Glutathione 0.000
Zevalin 0.000
CED 0.000
CTX 0.000
Filgrastim 0.000
CTX 0.000
Gel 0.000
Atovaquone 0.000
Filgrastim 0.000
CTX 0.000
Pefloxacin 0.000
Novantrone 0.000
Flavopiridol 0.000
Fludarabine 0.000
ABC 0.000
Diamminedichloroplatinum 0.000
Emodin 0.000
Atovaquone 0.000
Dihydro 0.000
EPI 0.000
Glucantime 0.000
Swertia 0.000
Emodin 0.000
Pyridoxal 0.000
ampicillin 0.000
KCL 0.000
Cremophor EL 0.000
CFS 0.000
ID2 0.000
Gefitinib 0.000
NovoSeven 0.000
Fluconazole 0.000
Lovastatin 0.000
DEL 0.000
Artesunate 0.000
ACT 0.000
Amifostine 0.000
Bortezomib 0.000
Retinoic Acid 0.000
Ranitidine 0.000
Pemetrexed 0.000
Photofrin 0.000
MDM 0.000
ETS 0.000
AZT 0.000
Trifluoperazine 0.000
Alanine 0.000
FLP 0.000
Doxycycline 0.000
AZT 0.000
Zoledronic acid 0.000
MTC 0.000
AMC 0.000
Paraffin 0.000
MRC 0.000
CoCl2 0.000
CoCl2 0.000
Clofibrate 0.000
CDP 0.000
G-CSF 0.000
Meropenem 0.000
Meth 0.000
Dasatinib 0.000
MAP 0.000
Ouabain 0.000
R1881 0.000
Meropenem 0.000
Gleevec 0.000
Isotretinoin 0.000
Phosphatidylserine 0.000
TAC 0.000
Bevacizumab 0.000
AGG 0.000
Zoledronic acid 0.000
NaI 0.000
NaI 0.000
NaI 0.000
NaI 0.000
Itraconazole 0.000
Methylprednisolone 0.000
DEX 0.000
Oxaliplatin 0.000
-deoxyadenosine 0.000
PCP 0.000
Cetuximab 0.000
GRF 0.000
more...
Enzyme
topoisomerase 1.000
topoisomerase 0.910
P-glycoprotein 0.001
DNA polymerase 0.000
EC 5.99.1.1 0.000
PARP 0.000
DNA ligase 0.000
DNA ligase 0.000
ATPase 0.000
MDR 0.000
endonuclease 0.000
thymidylate synthase 0.000
RNA polymerase 0.000
hydroxypyruvate isomerase 0.000
ribonucleotide reductase 0.000
ribonucleotide reductase 0.000
caspase-3 0.000
CPT 0.000
caspase-2 0.000
CPT 0.000
RNase M5 0.000
kallikrein 10 0.000
protein kinase 0.000
phosphodiesterase 0.000
glutathione S-transferase 0.000
cdc2 0.000
caspase-2 0.000
CPT 0.000
ERK 0.000
polo-like kinase 1 0.000
proteasome 0.000
micrococcal nuclease 0.000
DNase II 0.000
polynucleotide kinase 0.000
nucleoside triphosphate phosphohydrolase 0.000
S-formylglutathione hydrolase 0.000
DNase 0.000
dihydrofolate reductase 0.000
endonuclease VII 0.000
dCMP hydroxymethylase 0.000
protein kinase C 0.000
RNase H 0.000
deoxycytidine kinase 0.000
RNase 0.000
caspase-9 0.000
DNA methyltransferase 0.000
lambda exonuclease 0.000
thymidine kinase 0.000
RNase 0.000
caspase-8 0.000
caspase-1 0.000
AP lyase 0.000
enzyme X 0.000
proteinase K 0.000
dUTPase 0.000
mitogen-activated protein kinase 0.000
S1 nuclease 0.000
dCMP deaminase 0.000
exonuclease V 0.000
deoxycytidine deaminase 0.000
PIP kinase 0.000
STK2 0.000
luciferase 0.000
NQO1 0.000
FabH 0.000
carboxylesterase 0.000
reverse transcriptase 0.000
PTR1 0.000
prolyl-tRNA synthetase 0.000
Protein 2 0.000
Escherichia coli exonuclease III 0.000
deoxyribonuclease 0.000
DSR 0.000
amidophosphoribosyltransferase 0.000
glutamate racemase 0.000
penicillopepsin 0.000
endodeoxyribonuclease 0.000
alanine racemase 0.000
IMP dehydrogenase 0.000
deoxyguanosine kinase 0.000
chitin synthase 0.000
separase 0.000
inosine triphosphatase 0.000
pseudouridine synthase 0.000
poly(A) polymerase 0.000
ubiquinol-cytochrome c oxidoreductase 0.000
enoyl-ACP reductase 0.000
3'-phosphatase 0.000
enoyl-ACP reductase 0.000
ScpA 0.000
3'-exonuclease 0.000
coproporphyrinogen III oxidase 0.000
pyruvate formate-lyase 0.000
phosphatidylserine decarboxylase 0.000
dihydropyrimidine dehydrogenase 0.000
acyl carrier protein synthase 0.000
hypoxanthine-guanine phosphoribosyltransferase 0.000
ACS 0.000
aspartase 0.000
GM3 synthase 0.000
prolidase 0.000
caspase-6 0.000
caspase-7 0.000
caspase-7 0.000
branched-chain aminotransferase 0.000
dihydropteroate synthase 0.000
focal adhesion kinase 0.000
NCP 0.000
deoxyribonuclease 0.000
cytidine deaminase 0.000
protein phosphatase 2A 0.000
peptide deformylase 0.000
spermidine/spermine N1-acetyltransferase 0.000
coproporphyrinogen oxidase 0.000
thymidine phosphorylase 0.000
beta-galactosidase 0.000
MTD 0.000
dipeptidyl peptidase IV 0.000
pyruvate oxidase 0.000
pyruvate oxidase 0.000
nucleoside hydrolase 0.000
cysteine synthase 0.000
thymidylate kinase 0.000
phosphoinositide 3-kinase 0.000
NAT 0.000
asparaginase 0.000
TdT 0.000
LIS 0.000
dihydropyrimidine dehydrogenase 0.000
firefly luciferase 0.000
GCA 0.000
kinesin 0.000
beta-lactamase 0.000
trypsin 0.000
penicillin binding protein 0.000
peroxidase 0.000
orotate phosphoribosyltransferase 0.000
cathepsin B 0.000
disulfide reductase 0.000
Fpg protein 0.000
demethylase 0.000
Lys4 0.000
tryptophanase 0.000
folylpolyglutamate synthetase 0.000
restriction-modification system 0.000
azoreductase 0.000
MAP 0.000
PST 0.000
nicotinamide phosphoribosyltransferase 0.000
tryptophan 2,3-dioxygenase 0.000
thioredoxin reductase 0.000
ornithine decarboxylase 0.000
CYP3A4 0.000
IKK 0.000
xylose isomerase 0.000
calcineurin 0.000
argininosuccinate lyase 0.000
caspase-4 0.000
Rex 0.000
choline oxidase 0.000
more...
Compound
m-AMSA 0.013
VP-16 0.008
DNA 0.004
VM-26 0.003
ICRF-187 0.001
Camptothecin 0.001
Camptothecin 0.001
Camptothecin 0.001
Novobiocin 0.001
Topotecan 0.001
Merbarone 0.001
SN-38 0.001
Topotecan 0.001
Ellipticine 0.001
CPT-11 0.001
Adriamycin 0.000
Psorospermin 0.000
CI-921 0.000
Fostriecin 0.000
ATP 0.000
ADR 0.000
Mitoxantrone 0.000
Mitoxantrone 0.000
acridine 0.000
MIC 0.000
Clorobiocin 0.000
BLM 0.000
N-ethylhydrazinecarbothioamide 0.000
Podophyllotoxin acetate 0.000
8-Methoxycaffeine 0.000
C15H12O5 0.000
C15H12O5 0.000
Fagaronine 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
C15H12O5 0.000
6-bromo-9H-purine 0.000
1,3-bis(4-morpholinylmethyl)-2-imidazolidinethione 0.000
Kinamycin C 0.000
Elsamicin 0.000
Cryptolepine 0.000
benzo[a]phenazine 0.000
Genistein 0.000
beta-Lapachone 0.000
Usambarensine 0.000
Licodione 0.000
Albamycin 0.000
Lunacridine 0.000
C37H40N2O6 0.000
Mitindomide 0.000
2-butanone thiosemicarbazone 0.000
5H-indeno[1,2-b]pyridin-5-one 0.000
Lunacridine 0.000
Methoxycamptothecin 0.000
2-(dimethylamino)ethyl 0.000
2-(dimethylamino)ethyl 0.000
2,6-piperazinedione 0.000
Nalidixic acid 0.000
C19H18O8 0.000
Voacamine 0.000
6-methoxy-5,8-quinolinedione 0.000
Sitafloxacin 0.000
MDR 0.000
1-(phenylsulfonyl)-1H-indole 0.000
C17H20N2O3 0.000
NMHE 0.000
Ciprofloxacin 0.000
2-hydroxynaphthoquinone 0.000
2-hydroxynaphthoquinone 0.000
11H-indeno[1,2-b]quinoline 0.000
Mulberrofuran G 0.000
Moxifloxacin hydrochloride 0.000
11H-indeno[1,2-b]quinoline 0.000
Methanesulfonanilide 0.000
Chloroquinoxaline sulfonamide 0.000
benzo[i]phenanthridine 0.000
tyrosine 0.000
ADP-ribose 0.000
C14H12O3 0.000
9-cis-Retinal 0.000
Bimolane 0.000
Nogalamycin 0.000
Podophyllotoxin 0.000
benzo[c]phenanthridine 0.000
Vinca 0.000
Illudin S 0.000
Podophyllotoxin 0.000
Wedelolactone 0.000
Rubrofusarin 0.000
Pinobanksin 0.000
2,3-dihydro-1H-cyclopenta[b]quinoline 0.000
MTT 0.000
Coumermycin 0.000
Trovafloxacin 0.000
C18H18N2O5 0.000
quinoline 0.000
quinoline 0.000
3-aminobenzamide 0.000
Amonafide 0.000
Moxifloxacin 0.000
1-methyl-4-piperidinol 0.000
[1,2,4]triazolo[1,5-a]pyridine 0.000
benzo[g]isoquinoline-5,10-dione 0.000
Rebeccamycin 0.000
5,11-dimethyl-6H-pyrido[4,3-b]carbazole 0.000
Toxoflavin 0.000
MDA 0.000
Cyasorb 0.000
Quinalizarin 0.000
Diospyrin 0.000
6H-indolo[2,3-b]quinoxaline 0.000
dATP 0.000
CPT 0.000
Naringenin chalcone 0.000
9-chloroacridine 0.000
Butin 0.000
CPT 0.000
Aphidicolin 0.000
Aphidicolin 0.000
Petroselinic acid 0.000
CI-941 0.000
Cubebin 0.000
Piperlonguminine 0.000
Hoechst 33342 0.000
1,2,4-benzenetriol 0.000
bromide 0.000
salt 0.000
A 186 0.000
delta12,14-PGJ2 0.000
naphthoquinone 0.000
naphthoquinone 0.000
naphthoquinone 0.000
naphthoquinone 0.000
naphthoquinone 0.000
naphthoquinone 0.000
Bulbocapnine 0.000
Lucanthone 0.000
naphthoquinone 0.000
Salicylaldoxime 0.000
Chartreusin 0.000
Ametantrone 0.000
Mg2+ 0.000
Gatifloxacin 0.000
Deoxydoxorubicin 0.000
Daunorubicin 0.000
methyl methanesulfonate 0.000
Dec 0.000
ICRF 159 0.000
Xanthatin 0.000
hydrazinecarbothioamide 0.000
Isofraxidin 0.000
Amarogentin 0.000
ICRF 159 0.000
serine 0.000
ICRF 159 0.000
1,3-thiazolidine-2-thione 0.000
5-Formyluracil 0.000
9-AC 0.000
2-phenylnaphthalene 0.000
more...