Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
DNA gyrase 1142
topoisomerase I 959
Mol 884
DNA topoisomerase 832
ATP 621
Sep 611
p53 368
P-glycoprotein 244
ATPase 227
DNA topoisomerase I 218
histone 189
TOP2A 183
helicase 182
MIC 176
thymus 159
topoisomerase II alpha 139
caspase-3 136
ICRF 124
endonuclease 118
NMR 117
polypeptide 117
DNA polymerase 111
PARP 104
p21 100
Bcl-2 99
H2AX 96
MLL 95
AML 93
ATM 87
telomeric 85
fused 84
Ki-67 77
DNase I 75
DNA-dependent protein kinase 70
TOP1 67
proteasome 66
poly(ADP-ribose) polymerase 66
HER2 66
Pseudomonas 65
ADP 63
MDR1 60
Chk1 59
phosphodiesterase 59
DNA helicase 59
BLM 58
DNA topoisomerase 1 56
c-myc 55
colon carcinoma 55
tyrosine kinase 55
ATR 55
type I DNA topoisomerase 53
SDS 52
BRCA1 50
epidermal growth factor receptor 50
DNA polymerase alpha 47
ubiquitin 47
histone H3 46
thymidylate synthase 45
histone deacetylase 44
mdr1 44
proliferating cell nuclear antigen 43
Pol 41
bcl-2 40
MDS 40
RNA polymerase II 40
MX2 39
Fas 39
GSH 39
glutathione S-transferase 39
GST 38
ACS 38
glycoprotein 38
estrogen receptor 38
cytochrome c 38
DNA ligase 37
dimeric 37
MRP 37
A-T 37
osteosarcoma 37
topoisomerase II beta 37
RMI1 36
Chk2 35
tumor necrosis factor 35
cytokine 35
Gen 34
lymphoid 34
ADR 34
annexin V 33
EGFR 32
integrase 32
histone H1 31
nuclear protein 31
collagen 31
threonine 31
cyclin B1 30
SAR 30
caspase-9 30
CPT 29
PI3K 29
ribonucleotide reductase 29
cyclin D1 29
TOP2B 29
cytochrome P450 28
RAD51 28
AML1 28
promyelocytic leukemia 28
TDP1 28
phosphatase 28
RNase 28
erbB-2 27
AMP 27
TOP 27
SPO11 27
multidrug resistance-associated protein 27
ROS 26
vascular endothelial growth factor 26
cyclin 26
Rad51 26
mTOR 25
ataxia telangiectasia mutated 25
caspase-8 25
breakpoint cluster region 25
mer 25
ABCC1 25
P-gp 25
MAPK 25
ras 25
neu 24
AKT 24
p16 24
protein tyrosine kinase 24
WAF1 24
serum albumin 24
DNA binding protein 24
ALL 24
PC-3 24
p38 24
MIB 24
tyrosyl-DNA phosphodiesterase 1 23
dihydrofolate reductase 23
GTP 23
thymidine kinase 23
PARP1 22
cyclin A 22
TNF 22
Rad50 22
A431 22
WRN 22
RNA polymerase I 21
TOP3 21
p27 21
VEGF 21
LRP 21
ara 21
cyclin-dependent kinase 21
metallothionein 20
tRNA 20
DNA topoisomerase III 20
proteasome inhibitor 20
DNA-binding protein 20
more...
Disease
cancer 2377
tumor 1054
leukemia 607
breast cancer 355
acute myeloid leukemia 250
carcinoma 202
MCF 186
lung cancer 164
vaccinia 129
ATM 129
lymphoma 122
myelodysplastic syndrome 117
adenocarcinoma 112
colon cancer 108
melanoma 102
ovarian cancer 99
lung carcinoma 89
BLM 87
CEM 82
acute lymphoblastic leukemia 81
carcinogenesis 80
non-small cell lung cancer 77
tumor growth 76
hepatocellular carcinoma 73
Leukemia 73
prostate cancer 73
small cell lung cancer 73
colorectal cancer 70
metastases 65
Mycobacterium 64
acute promyelocytic leukemia 57
tuberculosis 55
HIV 53
tumorigenesis 53
acute leukemia 53
SDS 52
PSS 50
glioma 50
neutropenia 47
neuroblastoma 44
glioblastoma 44
WRN 42
MDS 40
sarcoma 40
multiple myeloma 39
scleroderma 39
GSH 39
anemia 38
osteosarcoma 38
solid tumor 38
Klebsiella 36
thrombocytopenia 35
Mycoplasma 34
epithelial ovarian cancer 33
Haemophilus 33
myeloid leukemia 32
squamous cell carcinoma 32
SAR 30
cervical cancer 30
tumor progression 30
gastric cancer 29
retinoblastoma 29
infectious diseases 29
secondary AML 28
leukemogenesis 28
leishmaniasis 26
Hodgkin's disease 26
myelosuppression 26
herpes simplex 26
pneumonia 25
malaria 25
chronic myeloid leukemia 24
pancreatic cancer 24
Fanconi 24
immunodeficiency 22
fibrosarcoma 22
cold 22
lymphoblastic leukemia 21
AIDS 20
non-Hodgkin's lymphoma 20
Epstein 19
SMC 18
erythroleukemia 18
suicide 18
DDP 18
bladder cancer 18
MRSA 17
renal cell carcinoma 17
B-cell lymphoma 17
systemic lupus erythematosus 17
virus infection 17
brain tumor 17
chronic lymphocytic leukemia 16
TAS 15
liver cancer 15
metastatic breast cancer 15
leukopenia 15
dysplasia 15
primary tumor 14
mammary tumor 14
xeroderma pigmentosum 14
TAM 14
liver cancer 14
PML 14
PDB 14
sepsis 13
autism 13
Ewing's sarcoma 12
APL 12
APL 12
gonococcal 12
APL 12
hematologic malignancies 12
MAR 12
cardiomyopathy 12
heart failure 12
testicular cancer 12
mole 11
mouse leukemia L1210 11
neuropathy 11
hepatitis B 11
CTX 11
rhabdomyosarcoma 11
African swine fever 11
renal cancer 10
smallpox 10
histiocytic lymphoma 10
autoimmune disease 10
glioblastoma multiforme 10
Burkitt's lymphoma 10
CREST 10
endometrial cancer 10
pancytopenia 10
Infection 9
ABL 9
pulmonary fibrosis 9
Fanconi syndrome 9
multiple sclerosis 9
blast crisis 9
schizophrenia 9
meningitis 9
Blocking 9
connective tissue disease 9
congestive heart failure 9
interstitial lung disease 9
childhood cancer 9
bends 8
childhood ALL 8
cytomegalovirus 8
African trypanosomiasis 8
histiocytic lymphoma 8
aggressiveness 8
skin cancer 8
RTS 8
genetic disorder 8
rheumatoid arthritis 8
Hepatocellular carcinoma 8
APC 8
premature aging 8
Chlamydia 8
more...
Symptom
diarrhea 40
collapse 20
starvation 17
ataxia 14
dyspnea 10
nausea 10
vomiting 9
nausea and vomiting 8
fatigue 8
pain 7
headache 6
seizures 6
ophthalmoplegia 4
cough 4
abdominal pain 4
asthenia 4
HSA 3
anorexia 3
weakness 3
splenomegaly 3
apathy 2
menopausal symptoms 2
erythema 2
hyperoxia 2
syncope 2
cerebellar ataxia 2
chills 2
decreased appetite 2
hoarseness 1
night sweats 1
hepatomegaly 1
muscle stiffness 1
bone pain 1
No adverse effect 1
eds 1
Halo 1
autodigestion 1
hepatosplenomegaly 1
skin damage 1
incoordination 1
sleepiness 1
disturbed balance 1
dysuria 1
paresthesia 1
hypoproteinemia 1
rhinorrhea 1
functional recovery 1
exhaustion 1
tonic-clonic seizure 1
discomfort 1
discomfort 1
hypotonia 1
anesthesia 1
colic 1
Drug
Etoposide 196
Adriamycin 111
CPT-11 93
DNase I 75
TTC 60
BLM 58
lysine 55
Irinotecan 41
caffeine 40
MDS 40
Mutagen 39
ADR 34
Asn 32
Dexrazoxane 27
ROS 26
Gel 18
Taxol 15
ampicillin 15
CTX 14
Herceptin 13
Gemifloxacin 13
ABC 12
VCR 12
Glutathione 12
Moxifloxacin 12
Teniposide 12
CTX 11
CTX 11
Docetaxel 10
ADM 10
GEO 10
VCR 10
Aclarubicin 9
MAP 9
AraC 9
Pixantrone 8
Dermatol 8
Taxotere 7
Idarubicin 7
Cardiovasc 7
Ofloxacin 7
Podophyllotoxin 7
Sitafloxacin 6
Leaf 6
TEL 6
ascorbate 6
Podophyllum 6
CSF 5
EPI 5
G-CSF 5
Gatifloxacin 5
Tirapazamine 4
Enrofloxacin 4
ACT 4
NADH 4
MRC 4
Sobuzoxane 4
Vorinostat 4
Gemzar 4
Vinorelbine 4
Alanine 4
AZT 4
Myricetin 4
ETS 4
AZT 4
Ranitidine 3
Gefitinib 3
Monit 3
Bortezomib 3
Ouabain 3
Compound 9 3
PCP 3
Radicicol 3
CED 3
CDP 3
Lovastatin 3
IL-2 3
Paraffin 3
Fluconazole 3
lactose 2
Dihydro 2
Gemifloxacin mesylate 2
NaI 2
-deoxyadenosine 2
Fludarabine 2
CFS 2
NaI 2
Photofrin 2
Avelox 2
FLP 2
CaCl2 2
Irofulven 2
Itraconazole 2
Dronedarone 2
CaCl2 2
CAM 2
Filgrastim 2
NaI 2
L-tyrosine 2
CoCl2 2
Emodin 2
Xeloda 2
Emodin 2
Bevacizumab 2
CoCl2 2
CaCl2 2
Pentostam 2
Meth 2
Gleevec 2
Fraction 2
Filgrastim 2
Cremophor EL 2
NH3 2
Fragment 2
Doxycycline 2
NOV 2
NaI 2
Navelbine 2
G418 2
p75 2
TAC 2
AMC 2
Gadoteridol 1
Rauwolfia serpentina 1
Azithromycin 1
HCH 1
balanced salt solution 1
CTC 1
Artesunate 1
Phosphatidylserine 1
Poudre 1
Zoledronic acid 1
NovoSeven 1
MOF 1
Fluorescein 1
R1881 1
Retinoic acid 1
Swertia 1
Glucantime 1
Forskolin 1
Rituximab 1
MTC 1
AGG 1
IFN-gamma 1
Gliadel 1
Retinoic Acid 1
Dasatinib 1
Dakar 1
Meropenem 1
Premafloxacin 1
FAD 1
Tarivid 1
FeCl3 1
ROC 1
Pyridoxal 1
GRF 1
Triclosan 1
IPM 1
Meropenem 1
Etoposide phosphate 1
more...
Enzyme
topoisomerase 9166
topoisomerase 9094
P-glycoprotein 247
ATPase 232
DNA polymerase 174
protein kinase 140
RNA polymerase 138
ERK 130
PARP 120
endonuclease 118
caspase-3 101
mitogen-activated protein kinase 74
glutathione S-transferase 70
protein kinase C 68
proteasome 67
phosphodiesterase 66
MDR 57
DNA ligase 52
DNA ligase 52
thymidylate synthase 51
cdc2 42
luciferase 39
RNase 38
ACS 38
ribonucleotide reductase 37
RNase 34
reverse transcriptase 34
DNase 30
ribonucleotide reductase 29
CPT 29
CPT 29
CPT 29
peroxidase 27
dihydrofolate reductase 26
focal adhesion kinase 26
caspase-9 24
thymidine kinase 23
catalase 22
trypsin 22
caspase-8 21
micrococcal nuclease 20
caspase-1 20
DNA methyltransferase 19
alkaline phosphatase 17
proteinase K 15
polo-like kinase 1 15
NQO1 15
RNase H 15
beta-galactosidase 14
caspase-2 14
S1 nuclease 13
beta-lactamase 12
caspase-2 12
lactate dehydrogenase 12
MEK 12
calcineurin 12
glutathione peroxidase 10
carboxylesterase 10
polynucleotide kinase 9
MAP 8
phosphoinositide 3-kinase 8
demethylase 7
APC 7
CYP3A4 7
deoxycytidine kinase 7
DNase II 7
glutathione reductase 7
kinesin 7
ornithine decarboxylase 7
ribonuclease 6
neuraminidase 6
chloramphenicol acetyltransferase 6
ATP synthase 6
IKK 6
phosphatidylinositol 3-kinase 6
AMPK 6
acetylcholinesterase 6
phosphorylase 6
deoxyribonuclease 6
hypoxanthine-guanine phosphoribosyltransferase 6
tyrosinase 6
cathepsin B 6
protein phosphatase 2A 6
superoxide dismutase 6
ribonuclease 6
beta-glucuronidase 5
chymotrypsin 5
asparaginase 5
carbonic anhydrase 5
transcriptase 5
firefly luciferase 5
alanine aminotransferase 5
histone acetyltransferase 4
creatine kinase 4
chitin synthase 4
deoxyribonuclease 4
succinate dehydrogenase 4
dipeptidyl peptidase IV 4
alcohol dehydrogenase 4
dUTPase 4
endonuclease VII 4
thioredoxin reductase 4
IMP dehydrogenase 4
TdT 4
PCP 3
N-acetyltransferase 3
histidine kinase 3
NADPH oxidase 3
lysozyme 3
dihydropyrimidine dehydrogenase 3
caspase-7 3
lambda exonuclease 3
phospholipase C 3
caspase-7 3
dihydropyrimidine dehydrogenase 3
complex I 3
AP lyase 3
sialidase 3
Protein 2 3
MMP 3
thymidine phosphorylase 3
thrombin 3
cathepsin L 3
aldehyde dehydrogenase 3
GSK 3
diaphorase 3
poly(A) polymerase 3
CD13 3
chaperonin 3
cathepsin D 3
aspartate aminotransferase 3
cytidine deaminase 3
hyaluronidase 2
hyaluronidase 2
PST 2
alanine racemase 2
tissue plasminogen activator 2
plasmin 2
urokinase-type plasminogen activator 2
PIP kinase 2
glyceraldehyde-3-phosphate dehydrogenase 2
prostate-specific antigen 2
cysteine synthase 2
Rex 2
histone demethylase 2
PRE 2
MTD 2
pyruvate dehydrogenase 2
phospholipase D 2
farnesyltransferase 2
FabH 2
caspase-6 2
NOS 2
Alternating 2
prolidase 2
TSA 2
farnesyltransferase 2
acid phosphatase 2
glyceraldehyde-3-phosphate dehydrogenase 2
BMT 2
more...
Compound
DNA 5828
Dec 645
ATP 621
VP-16 469
m-AMSA 246
tyrosine 234
oxygen 220
Clin 205
Adriamycin 185
MIC 176
salt 163
VM-26 153
phosphate 147
hydrogen 130
sodium 119
MTT 118
acridine 113
ADR 112
water 110
serine 109
bromide 100
lysine 98
CPT-11 92
MDA 87
alanine 86
calcium 82
Camptothecin 81
Camptothecin 80
Camptothecin 80
nitrogen 77
SN-38 76
Mg2+ 76
Phe 73
arginine 72
sulfate 67
ADP 66
Asp 66
cysteine 64
ADP 63
ADP 63
leucine 62
BLM 60
MDR 57
ADP-ribose 56
SDS 55
Topotecan 54
threonine 54
Topotecan 54
quinoline 53
pyridine 53
quinoline 52
zinc 51
copper 51
GSH 50
GSH 50
glucose 50
iron 50
pyrimidine 49
pyrimidine 49
Novobiocin 48
ICRF-187 47
Genistein 46
benzene 44
caffeine 40
acetate 39
ACS 38
galactose 38
ACS 38
Ciprofloxacin 37
His 36
iodine 35
Mitoxantrone 34
Mitoxantrone 34
retinoic acid 31
DDP 31
CPT 31
potassium 29
CPT 29
Ile 29
EDTA 28
EDTA 28
formaldehyde 28
PEG 27
AMP 27
fluorine 26
formaldehyde 26
Gly 26
NH2 26
methionine 25
naphthoquinone 24
2-(dimethylamino)ethyl 24
Ellipticine 24
naphthoquinone 24
naphthoquinone 24
dUTP 24
hydroquinone 24
naphthoquinone 24
naphthoquinone 24
dATP 24
2-(dimethylamino)ethyl 24
naphthoquinone 24
GTP 24
naphthoquinone 24
Hoechst 33342 23
manganese 22
5-FU 22
TNF 22
proline 21
methyl methanesulfonate 21
MgCl2 20
piperazine 20
DMSO 19
glutamate 19
chalcone 19
chlorine 19
NAD 19
glycerol 19
N-acetylcysteine 18
3-aminobenzamide 18
isoquinoline 17
NAD 17
PEG 17
H2O2 17
anthracene 17
Vinca 17
nitric oxide 17
Nalidixic acid 16
phenol 16
ethanol 16
HCl 16
THP 16
cyanide 15
ammonium 15
C-3 15
THP 15
methane 15
Cu(II) 15
Merbarone 14
methanol 14
myricetin 14
Ara-C 14
BCNU 14
urea 14
DEAE 14
tryptophan 14
CTX 14
PDB 14
Resveratrol 13
thiophene 13
glutamine 12
Moxifloxacin 12
CAM 12
thiourea 12
aspartic acid 11
phenazine 11
hydroxide 11
NADPH 11
ethyl acetate 11
nickel 11
CI-921 11
more...