Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.99.1.2 (topoisomerase)
 9,166 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During our search for cancer chemopreventing compounds derived from plant sources, we discovered that the natural product GUT-70, isolated from the stem bark of Calophyllum Brasiliense collected in Brazil, significantly inhibited the growth of leukemic cells via the induction of caspase-mediated and p53-independent apoptosis. Furthermore, we synthesized BNS-22 as a derivative of GUT-70, which showed more antiproliferative activity against human cancer cells than GUT-70. GUT-70 and BNS-22 commonly inhibited ubiquilin-1, suggesting that a GUT-70 derivative might become a First in Class agent. In addition, GUT-70 and BNS-22 inhibited HSP90 and topoisomerase II, respectively. Recently, we also found that GUT-70 inhibited HIV replication. These findings indicated that GUT-70 could serve as a lead compound to develop novel therapeutic agents against cancer and HIV-1 infection.
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PMID:[Possibility of the natural product extracted from Calophyllum Brasiliense]. 2516 31