Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:5.4.2.8 (phosphomannomutase)
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Human Gene/Protein
Phosphomannomutase 17.0
phosphomannomutase 17.0
PMM1 16.0
asparagine-linked glycosylation 6 16.0
CDG Ia 15.6
PMM2 15.4
GDP-mannose pyrophosphorylase 14.8
phosphomannomutase 2 14.5
PGM2L1 14.4
phosphomannose isomerase 14.4
phosphoribosylformylglycinamidine synthase 13.9
L-3-phosphoserine phosphatase 13.7
RY1 13.4
MPDU1 13.4
PPM2 13.3
phosphoglucomutase 2 13.2
N-acetylglucosaminyltransferase II 13.2
ALG6 12.9
GMPPB 12.9
SRD5A3 12.5
phosphoacetylglucosamine mutase 12.5
ALG8 12.4
lysosomal alpha-mannosidase 12.2
ALG12 12.0
mannose phosphate isomerase 12.0
PGM 12.0
PGM2 12.0
phosphate cyclase 11.7
MGAT2 11.6
SGK2 11.5
ALG3 11.5
Phenylalanyl-tRNA synthetase 11.3
phosphoglyceromutase 10.9
SP-2 10.6
Phosphoglucomutase 10.6
SGK3 10.6
DNA-directed RNA polymerase 10.5
ORF-2 10.4
dolichol kinase 10.1
mannosyltransferase 10.1
signal transduction protein 10.0
MPI 10.0
phosphoserine phosphatase 10.0
TUP1 10.0
putative glycosyltransferase 9.9
DPAGT1 9.8
FKHRL1 9.7
PGM1 9.6
UDP-galactose 4-epimerase 9.5
oligosaccharyltransferase 9.5
SGK 9.3
Rieske iron-sulfur protein 9.3
UDPG 9.3
Glucokinase 9.3
IMPDH 9.2
TRPV5 9.1
GDP 9.0
HEXB 8.9
cysteine desulfurase 8.9
6-phosphofructokinase 8.9
Nedd4-2 8.8
UDP-glucose pyrophosphorylase 8.7
glucosamine-6-phosphate 8.6
L-lactate dehydrogenase 8.5
Enolase 8.5
CACNA1A 8.4
PACAP receptor 8.4
BOS 8.3
FACE 8.3
APOC3 8.3
PMI 8.2
ROMK 8.2
arylsulphatase 8.2
EF-2 8.2
glutamate-cysteine ligase 8.2
PHI 8.1
phosphoglycerate mutase 8.1
MYPT1 8.1
LAM 8.0
PAD 8.0
HAD 8.0
KCNE1 8.0
GluR6 8.0
DNaseI 7.9
strabismus 7.9
S19 7.8
hexosaminidase A 7.8
MT-1 7.8
GDH 7.7
transferrin 7.7
inorganic pyrophosphatase 7.7
glyoxalase I 7.7
forkhead transcription factor 7.6
UDP-glucuronic acid 7.5
UDP-N-acetylglucosamine 7.5
Kv1.3 7.4
MAD 7.3
PSP 7.2
GAL1 7.2
SGLT1 7.2
protein-tyrosine kinase 7.2
NHE3 7.2
metallopeptidase 7.2
GT1 7.2
GLAST 7.1
glucosyltransferase 7.1
PTP 7.1
GAL 7.1
PDK1 7.1
ENaC 7.1
KCNQ1 7.0
14-3-3 protein 7.0
glycosyltransferase 7.0
C21 7.0
glucose dehydrogenase 6.9
MT1 6.8
alpha-mannosidase 6.7
MMR 6.7
triosephosphate isomerase 6.7
transketolase 6.7
glycoprotein 6.7
6-phosphogluconate dehydrogenase 6.6
glucokinase 6.5
glyceraldehyde-3-phosphate dehydrogenase 6.5
DEAD 6.4
RNA helicase 6.4
pyrophosphatase 6.4
ORF1 6.3
SIN 6.3
Pseudomonas 6.2
MIM 6.2
LIF 6.2
heparan sulfate proteoglycan 6.1
GTP-binding protein 6.0
PGD2 6.0
manganese superoxide dismutase 5.9
galactosyltransferase 5.9
GMP 5.8
MMP2 5.8
CD62L 5.7
glycogen synthase 5.7
E.coli 5.7
GAL4 5.6
hinge 5.6
GLUT1 5.5
isocitrate dehydrogenase 5.5
IMP 5.5
defensin 5.5
lipopolysaccharide 5.4
C-1 5.4
STR 5.3
CD1 5.3
K12 5.3
RACE 5.2
enolase 5.2
malate dehydrogenase 5.2
pseudogene 5.2
protein tyrosine kinase 5.2
protein tyrosine phosphatase 5.1
IL-13 4.9
ABC 4.9
unknown function 4.9
glucosamine 4.8
TCA 4.8
hexokinase 4.7
intercellular adhesion molecule-1 4.7
ubiquitin ligase 4.7
endoplasmic reticulum 4.7
antithrombin III 4.6
sit 4.6
Walker 4.5
glucose-6-phosphate dehydrogenase 4.4
ORF 4.4
polypeptide 4.3
phosphatase 4.2
NADP 4.2
transmembrane protein 4.2
LPS 4.2
phosphoprotein 4.2
mucin 4.1
HSP70 4.1
oxidoreductase 4.1
beta-glucuronidase 4.0
beta-catenin 4.0
helicase 3.9
GTP 3.9
Polymerase 3.9
von Willebrand factor 3.8
plasminogen 3.7
TOF 3.7
phosphatidylinositol 3-kinase 3.6
osteocalcin 3.6
neuraminidase 3.5
dimeric 3.5
mer 3.4
proteasome 3.4
reductase 3.3
cryptic 3.3
lectin 3.2
IL-4 3.2
UTR 3.1
matrix metalloproteinase 3.1
SDS 3.0
IL-10 2.9
FSH 2.9
ESI 2.7
SOD 2.7
Gen 2.6
calmodulin 2.4
NADPH 2.4
NMR 2.4
lactate dehydrogenase 2.4
tRNA 2.3
She 2.3
membrane-bound 2.2
membrane protein 2.2
IFN-gamma 2.2
ATPase 2.2
Mol 2.1
ADP 1.8
MRI 1.6
ATP 1.6
alkaline phosphatase 1.5
albumin 1.1
hemoglobin 1.1
gut 0.9
ACS 0.8
insulin 0.3
collagen 0.1
Pol -0.0
cytokine -0.1
Sep -0.2
Disease
CDG IIa 17.0
CDG Ia 16.1
CDG Ic 16.0
CDG Ib 15.7
Carbohydrate-deficient glycoprotein syndrome 15.1
congenital disorder 10.8
Pontiac fever 10.4
hereditary fructose intolerance 10.4
Familial hemiplegic migraine 9.8
olivopontocerebellar atrophy 9.7
Brucella canis 9.2
protein-losing enteropathy 9.0
galactosemia 9.0
Meadow 8.6
MBS 8.5
Brucella suis 8.4
gastrointestinal dysfunction 8.2
mild mental retardation 8.0
cerebellar syndrome 8.0
failure to thrive 7.9
Brucella melitensis 7.6
emerging infectious disease 7.3
complex partial seizures 7.3
PSP 7.2
PTP 7.1
intellectual impairment 7.0
legionellosis 7.0
developmental delay 6.8
coagulopathy 6.7
canker 6.7
strabismus 6.7
EPS 6.6
EPS 6.5
lymphangioleiomyomatosis 6.4
L. infantum 6.4
premature ovarian failure 6.4
Brucella abortus 6.4
hypernatremia 6.3
Turner syndrome 6.3
Ehlers-Danlos syndrome 6.1
congenital hypothyroidism 6.0
Q fever 5.9
Thrombus 5.9
metabolic disorder 5.8
pericardial effusion 5.7
liver abscess 5.7
hypogonadism 5.7
retinitis pigmentosa 5.7
mental retardation 5.4
mental retardation 5.4
gastrointestinal disease 5.4
brucellosis 5.4
endophthalmitis 5.3
progressive supranuclear palsy 5.3
thrombocytosis 5.2
mucosa-associated lymphoid tissue 5.2
IgA nephropathy 5.1
Cryptococcus neoformans 5.0
leishmaniasis 4.9
enteropathy 4.9
dilated cardiomyopathy 4.9
peripheral neuropathy 4.7
hypoglycemia 4.7
hypothyroidism 4.6
cystic fibrosis 4.4
gonococcal 4.4
cardiomyopathy 4.3
Legionella 4.3
malnutrition 4.2
hypertrophic cardiomyopathy 4.2
peritonitis 4.1
polyneuropathy 4.1
liver fibrosis 4.0
mastitis 4.0
Chagas 4.0
encephalopathy 3.9
neurological disease 3.9
nephrotic syndrome 3.7
deafness 3.7
Klebsiella 3.6
neuropathy 3.5
respiratory failure 3.2
pancreatitis 3.1
rash 3.0
SDS 3.0
cognitive impairment 2.9
osteoporosis 2.8
meningitis 2.7
epilepsy 2.6
metabolic syndrome 2.5
infertility 2.4
cytomegalovirus 2.2
cataract 2.2
thrombocytopenia 2.2
hepatitis 2.1
autism 2.0
dysplasia 2.0
heart failure 1.9
ischemia 1.6
cold 1.5
stroke 1.4
sepsis 1.4
Mycobacterium 1.4
plaque 1.3
tumor growth 1.2
sepsis 1.2
West 0.9
tuberculosis 0.8
hypertension -0.3
Symptom
Spots 8.2
hypotonia 7.8
leg edema 7.6
intestinal bleeding 7.4
bloating 6.3
ataxia 6.2
incoordination 6.2
cerebellar ataxia 6.2
dysarthria 6.2
twitching 6.0
hepatomegaly 5.5
hepatosplenomegaly 4.9
vomiting 3.7
seizures 3.1
diarrhea 2.8
starvation 2.4
Drug
Fragment 5.8
ABC 4.9
Asn 3.5
Leaf 2.6
IFN-gamma 2.2
Enzyme
phosphomannomutase 17.0
GDP-mannose pyrophosphorylase 14.8
formyltetrahydrofolate deformylase 14.7
2-ketogluconate kinase 14.4
GDP-mannose dehydrogenase 14.3
mannosyl-3-phosphoglycerate phosphatase 14.2
phosphoacetylglucosamine mutase 14.2
phosphomannose isomerase 14.0
beta-phosphoglucomutase 13.7
mannosyl-3-phosphoglycerate synthase 13.6
Rmd 13.2
N-acetylglucosaminyltransferase II 13.1
phosphoglucosamine mutase 12.9
phosphoglucomutase 12.5
FGAM synthetase 12.0
GDP-mannose 4,6-dehydratase 11.4
3-hydroxybutyryl-CoA dehydrogenase 11.3
PGM 11.3
deoxyribose-5-phosphate aldolase 11.2
phosphopentomutase 11.1
dolichol kinase 11.1
phosphoenolpyruvate synthase 11.0
gluconate dehydrogenase 10.6
elongation factor (EF) 10.4
3-dehydroquinate 10.2
phosphoserine phosphatase 10.0
UMP kinase 9.8
phosphoglyceromutase 9.4
polyphosphate kinase 9.2
orotidine-5'-phosphate decarboxylase 8.6
starch synthase 8.3
4-epimerase 8.3
IscS 8.3
ADP-glucose pyrophosphorylase 7.9
phosphoglucose isomerase 7.9
3-hydroxyacyl-CoA dehydrogenase 7.6
SOR 7.5
alpha-L-fucosidase 7.5
alpha-mannosidase 7.5
lactic acid dehydrogenase 7.4
arginine deiminase 7.3
mannanase 7.1
glucose dehydrogenase 7.0
transketolase 6.7
peroxiredoxin 6.7
gamma-glutamylcysteine synthetase 6.5
glucokinase 6.5
6-phosphogluconate dehydrogenase 6.5
6-phosphogluconate dehydrogenase 6.5
glyceraldehyde-3-phosphate dehydrogenase 6.5
glyceraldehyde-3-phosphate dehydrogenase 6.5
glyceraldehyde-3-phosphate dehydrogenase 6.4
hexosaminidase 6.2
glyceraldehyde-3-phosphate dehydrogenase 6.2
glyceraldehyde-3-phosphate dehydrogenase 5.9
PDK1 5.9
isocitrate dehydrogenase 5.4
STR 5.4
isocitrate dehydrogenase 5.3
enolase 5.2
phosphofructokinase 5.1
malate dehydrogenase 4.9
hexokinase 4.7
phosphorylase 4.6
urease 4.2
beta-galactosidase 4.2
urease 4.2
beta-glucuronidase 4.1
glucose-6-phosphate dehydrogenase 4.1
phosphatidylinositol 3-kinase 3.6
proteasome 3.2
neuraminidase 3.2
lactate dehydrogenase 3.2
reverse transcriptase 3.1
RNA polymerase 2.9
ATPase 2.0
trypsin 1.7
alkaline phosphatase 1.5
ACS 0.8
protein kinase 0.7
Compound
mannose-1-P 14.6
GDP-D-mannose 11.4
D-ribose-5-phosphate 10.8
D-glucose 1-phosphate 10.6
dolichyl-phosphate 10.1
glucose-6-phosphate 9.8
Dolichol 9.8
Mannose 9.8
glucosamine-6-phosphate 9.7
Xanthan 9.6
GDP 9.0
Glucose 6-phosphate 8.5
N-acetylmannosamine 8.4
ribose-5-phosphate 8.4
SP-1 8.2
fructose-6-P 8.2
dihydrogen phosphate 7.6
Alginate 7.5
galactose 7.4
hexose 7.4
MAD 7.3
UDP-glucose 7.2
FDP 7.1
TDP 7.1
PSP 7.1
phosphoserine 6.7
Histidine 6.5
GlcNAc 6.3
UDP-GlcNAc 6.2
hexose 6.1
hexose 6.1
hexose 6.1
Genistein 6.0
UGA 6.0
phosphate 5.8
NTA 5.7
Phosphatidylinositol 5.6
S-adenosylhomocysteine 5.6
asparagine 5.5
IMP 5.4
acetamide 5.2
acetamide 5.2
GMP 4.9
UTP 4.8
GAL 4.8
xylose 4.8
pentose 4.4
pentose 4.4
pentose 4.4
pentose 4.3
Mg2+ 4.2
glucose 4.2
Sucrose 4.2
DEAE 4.1
Phytol 4.0
Phytol 4.0
TCA 3.9
GTP 3.8
TOF 3.7
salicylic acid 3.6
NADP 3.6
manganese 3.5
Triton X-100 3.1
CoA 3.1
nickel 3.1
serine 3.0
Optimal 2.9
Asp 2.9
alanine 2.9
SDS 2.9
His 2.8
NADPH 2.4
NADPH 2.4
cobalt 2.3
proline 2.1
sulfate 1.8
ADP 1.8
ADP 1.8
hydrogen 1.7
ADP 1.7
ATP 1.6
ammonia 1.6
arginine 1.5
Phe 1.4
DNA 1.4
PEG 1.2
salt 1.2
leucine 1.1
sodium 0.9
glutamate 0.9
cysteine 0.8
ACS 0.8
ACS 0.8
nitrogen 0.8
zinc 0.6
oxygen 0.5
Dec 0.5
copper 0.5
tyrosine 0.5
nitric oxide 0.4
water 0.2
ethanol -0.1
Clin -0.7
calcium -1.3