Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.2 (guanylate cyclase)
 8,497 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
prostaglandin I2 (prostacyclin) receptor 11.9
guanylate cyclase 1, soluble, beta 3 11.9
guanylate cyclase-activating protein 2 11.9
GUANYLATE CYCLASE 11.9
guanylate cyclase 11.9
COD3 11.9
guanylyl cyclase 11.9
heat-stable enterotoxin receptor 11.7
GCAP2 11.6
GCAP3 11.5
Guanylate cyclase 11.4
GCAP1 11.3
GUCA1B 11.3
CORD5 11.3
GCAP 11.2
GUCY2D 11.2
ROS-GC1 11.1
retinal degeneration 3 11.1
GC-E 11.0
SOX25 10.9
guanylate cyclase activating protein 10.9
PDZD3 10.9
G-protein-coupled receptor kinase 1 10.9
PRKG1 protein 10.9
guanylin 10.8
GUCA1A 10.8
cGMP-phosphodiesterase activity 10.7
NPR-A 10.7
uroguanylin 10.7
Guanylyl cyclase 10.6
NPR-B 10.6
GC-F 10.5
GUCY1B3 10.5
GPSM4 10.3
natriuretic peptide clearance receptor 10.3
cGMP-stimulated phosphodiesterase 2 10.3
natriuretic peptide receptor A 10.2
natriuretic peptide receptor B 10.2
NPR-C 10.1
GCA1 9.9
HKB3 9.9
D2LIC 9.9
F-box domain protein 9.9
regulator of G-protein signalling 9 9.9
C-type natriuretic peptide 9.8
GUCY1A3 9.8
neurocalcin delta 9.6
neurocalcin 9.6
GKAP42 9.6
PKG1 9.6
PDZ domain-containing protein 2 9.6
MAP kinase phosphatase 5 9.6
cGMP phosphodiesterase 9.4
PKG 9.4
GC1 9.4
CHL1 protein 9.3
guanylyl cyclase C 9.2
GUCY2C 9.2
soluble guanylyl cyclase 9.2
Nucleoside diphosphokinase 9.1
cGKI 8.9
PDE1B1 8.9
FIN13 8.9
recoverin 8.8
CNP 8.8
PTCHD3 8.7
RAB28 8.7
SIN 8.7
NPR 8.6
rab28 8.6
CaM-PDE 8.6
Cocaine-and amphetamine-regulated transcript 8.6
ANF 8.5
EDRF 8.5
atrial natriuretic factor 8.5
ZIN 8.4
3',5'-cyclic-nucleotide phosphodiesterase 8.4
ANP 8.4
RD3 8.3
PDE5 8.3
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Disease
difficile; Clostridium 11.9
COD3 11.9
relaxation; bladder 11.9
CORD5 11.3
LCA12 10.9
CORD6 10.1
Chronic idiopathic constipation 10.0
Congenital sodium diarrhea 9.9
Cone dystrophy 9.7
Macular dystrophy 9.3
Multiple carboxylase deficiency 9.1
Central areolar choroidal dystrophy 8.9
CHEST 8.9
Hereditary retinal dystrophies 8.4
dual personality 8.2
Unilateral renal artery stenosis 8.2
NAME 7.5
PAPA 7.2
Biotin deficiency 6.9
PDE 6.9
AGS3 6.8
Retinal degeneration 6.8
NINA 6.6
Persistent pulmonary hypertension 6.5
renin-dependent hypertension 6.4
Flashing 6.4
Pulmonary arterial hypertension 6.4
LCA 6.3
persistent pulmonary hypertension of the newborn 6.2
Pineal gland 5.9
Pineal gland 5.9
Pineal gland 5.9
Myometrium 5.9
cholestatic cirrhosis 5.8
vascular dilation 5.7
RAT 5.6
hypotension and shock 5.4
E. coli septicemia 5.4
Postoperative ileus 5.3
hypertensive cardiomyopathy 5.3
erectile dysfunction 5.3
Portopulmonary hypertension 5.3
pulmonary hypertension 5.3
Purging 5.2
orphan disease 5.2
SFD 5.1
cardiac overload 5.1
retinal vascular occlusion 5.1
Traveler's diarrhea 4.9
Endothelial dysfunction 4.8
Trachea 4.8
Trachea 4.8
Trachea 4.7
Recessive dystrophic epidermolysis bullosa 4.7
Ureteral obstruction 4.6
Diabetes and Pregnancy 4.6
ISD 4.6
right heart failure 4.5
CHH 4.5
irritable bowel syndrome 4.5
achromatopsia 4.4
Chronic heart failure 4.4
Primary open-angle glaucoma 4.3
Tension 4.3
adrenocortical carcinoma 4.3
SMC 4.3
Malassez 4.3
Waardenburg syndrome 4.2
achondroplasia 4.2
pertussis 4.2
HTX 4.1
TNS 4.1
HTX 4.1
Endometrium 4.0
Endometrium 4.0
fluid overload 4.0
leprechaunism 4.0
gastroparesis 4.0
Functional dyspepsia 4.0
cerebral vasospasm 4.0
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Symptom
Simple constipation 11.9
Functional abdominal pain 6.4
Functional constipation 6.0
chronic constipation 5.2
bloating 4.5
Lower urinary tract symptoms 4.3
constipation 4.2
Anoxia 3.8
clonus 3.3
bladder pain 3.3
hyperoxia 3.2
loss of balance 3.1
orofacial pain 3.0
hyperesthesia 2.8
abdominal cramps 2.8
despair 2.8
Gastrointestinal symptoms 2.7
angina 2.6
diarrhea 2.6
spasm 2.5
HSA 2.3
acute pain 2.2
general problem 2.1
hypercapnia 1.9
microbial colonization 1.8
colic 1.8
urinary frequency 1.7
exertional dyspnea 1.7
nasal congestion 1.7
analgesia 1.7
skin damage 1.3
polyuria 1.3
photophobia 1.2
flushing 1.2
hypocapnia 1.1
abdominal discomfort 1.1
abdominal pain 0.9
hypothermia 0.8
tense 0.8
polydipsia 0.8
functional recovery 0.7
bradykinesia 0.7
respiratory distress 0.6
erythema 0.5
pain 0.4
hemoptysis 0.3
ataxia 0.2
epigastric pain 0.1
starvation 0.1
memory loss 0.1
discomfort 0.0
headache -0.1
pelvic pain -0.1
discomfort -0.1
dystonia -0.2
seizures -0.2
chest pain -0.2
acute stress -0.3
collapse -0.3
wheezing -0.4
anesthesia -0.4
ENT -0.5
hunger -0.6
myalgia -0.8
tinnitus -0.8
dyspnea -0.9
vertigo -0.9
arthralgia -0.9
acidity -1.0
tremor -1.3
syncope -1.3
dizziness -1.4
splenomegaly -1.4
thinning -1.6
nausea -1.6
agitation -1.7
back pain -1.7
stigma -1.8
anorexia -1.9
weakness -2.3
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Drug
N-Hydroxyguanidine 10.3
Carperitide 9.6
Methylene blue 9.3
Sodium nitroprusside 9.3
Nipradilol 8.9
Leminoprazole 8.9
7-Nitroindazole 8.0
Quinaprilat 7.8
Avanafil 7.7
Equilin 7.6
Cicletanine 7.5
Pentaerythritol tetranitrate 7.3
Molsidomine 7.2
L-Homoarginine 7.2
Nitric Oxide 6.9
Viagra 6.7
Viagra 6.6
nitroglycerin 6.5
Gly-Tyr-Gly 6.5
Regitine 6.5
Nesiritide 6.5
Heme 6.2
Nebivolol 6.1
PBZ 6.1
Ergometrine 6.1
Ibudilast 6.0
Batroxobin 5.9
Tegaserod 5.7
Omapatrilat 5.7
Ferrous sulfate 5.6
Ramelteon 5.6
Aminoguanidine 5.5
Timolol maleate 5.4
Tegaserod 5.4
Vardenafil 5.4
Treprostinil 5.4
Quisqualate 5.4
Malonaldehyde 5.2
Glybenclamide 5.2
Iloprost 5.1
Rolipram 5.1
Forskolin 5.1
Phosphoramidon 5.1
Trifluoperazine 5.1
Red ginseng 5.0
BH4 4.9
Vinpocetine 4.7
Trental 4.6
Lead acetate 4.6
Guanidine 4.5
Guanidine 4.5
Dronedarone 4.5
ETA 4.4
Angiotensin II 4.4
Salmon calcitonin 4.4
Dihydroergotamine 4.3
Carbenoxolone 4.3
Tranilast 4.2
Thiopentone 4.2
Bumetanide 4.2
Indomethacin 4.2
Atropine 4.1
Calcium chloride 4.1
Emodin 4.0
Tubocurarine 3.9
Escitalopram 3.9
CaCl2 3.9
CaCl2 3.9
CaCl2 3.9
Luteinizing 3.8
Zmax 3.8
ICI 3.8
KCL 3.8
Guanethidine 3.8
Ouabain 3.7
Atenolol 3.7
Bestatin 3.7
Emodin 3.7
Histamine 3.7
Phentolamine 3.7
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Enzyme
EC 1.13.11.49 11.9
guanylate cyclase 11.9
isoflavone 7-O-glucosyltransferase 9.6
cGMP phosphodiesterase 9.4
PKG 9.4
2-hydroxyisoflavanone dehydratase 9.1
cytidylate cyclase 8.7
retinol isomerase 8.0
2-hydroxyisoflavanone synthase 7.9
NO synthase 7.7
rhodopsin kinase 7.7
lecithin-retinol acyltransferase 7.6
EC 5.3.3.2 7.5
steroid 11beta-hydroxylase 7.5
phosphodiesterase 7.3
NOS 7.0
PDE 6.9
heme oxygenase 6.8
adenylate cyclase 6.6
ecdysone 20-monooxygenase 6.4
protein N-myristoyltransferase 6.3
6-pyruvoyltetrahydropterin synthase 6.3
GMP synthase 6.1
biliverdin reductase 6.1
tyrosylprotein sulfotransferase 6.0
NADPH-diaphorase 6.0
SNO 5.9
carboxypeptidase S 5.7
isoflavone reductase 5.6
protein kinase 5.4
GCA 5.2
lipoxygenase 4.9
lysophosphatidylcholine acyltransferase 4.8
EC 3.6.1.1 4.8
prolinase 4.7
thromboxane synthase 4.7
anthocyanidin synthase 4.7
LipA 4.7
GMP synthetase 4.6
phospholipase C 4.6
CPT 4.6
inosine triphosphatase 4.6
nucleoside diphosphokinase 4.5
lecithin:retinol acyltransferase 4.5
BBE 4.5
GTP cyclohydrolase I 4.5
CPT 4.5
propionyl-CoA carboxylase 4.5
VIP1 4.5
3'-phosphatase 4.5
ADP-ribosyltransferase 4.5
propionyl-CoA carboxylase 4.4
ADP-ribosyltransferase 4.4
clotting enzyme 4.4
sepiapterin reductase 4.4
cytochrome P-450scc 4.3
prostacyclin synthase 4.3
CD10 4.3
N-acetylglucosaminyltransferase I 4.2
cinnamate 4-hydroxylase 4.2
PIP kinase 4.2
myosin light chain kinase 4.2
endoproteinase Glu-C 4.2
diaphorase 4.1
arylamine N-acetyltransferase 4.1
CPT 4.1
CPN 4.1
argininosuccinate synthetase 4.0
protein kinase C 4.0
AMP-activated kinase 4.0
protein phosphatase 2A 4.0
guanase 4.0
eEF2 kinase 4.0
AMPK 4.0
diacylglycerol kinase 3.9
pantothenate kinase 3.9
PTPase 3.9
xanthine oxidase 3.9
SPT 3.8
phospholipase A2 3.8
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Compound
5-Nitroisatin 11.9
D-NONOate 11.9
Vindorosine 11.9
Tetrahydroneopterin 10.9
8-iso-PGF2beta 10.9
8-Br-cGMP 10.1
8-iso-PGE1 9.7
cGMP 9.6
SB 200646 9.6
Eudesmin 9.1
C7H9N3O3 9.1
Caracemide 9.1
LNO2 9.0
Methylene blue 8.9
3-Chlorotyrosine 8.9
Acetylcholine chloride 8.9
Capillarisin 8.9
8-iso-PGE2 8.6
NPR 8.6
ethanimidamide 8.6
GMP 8.4
Lubiprostone 8.3
Nitroprusside 8.3
D-Arginine 8.3
HM-5 8.3
DEA 8.3
DEA 8.3
DETA 8.2
DEA 8.2
Indicaxanthin 8.2
Isatin 8.1
Cubebin 8.1
N-(2-hydroxyethyl)nicotinamide 8.1
Sinensetin 8.1
C3H7NO2 8.1
Nicorandil 8.0
Lys-vasopressin 8.0
Sodium bromide 8.0
Nitro-L-arginine 8.0
Piloty's acid 7.9
BW619C89 7.9
imidazo[1,5-a]pyridine 7.7
Amarogentin 7.6
Adrenochrome 7.6
2-aminoethyl diphenylborinate 7.6
2-aminoethyl diphenylborinate 7.6
Amaranthin 7.6
1-phenylethanone 7.6
1-phenylethanone 7.6
1-phenylethanone 7.6
1-phenylethanone 7.6
Relaxant 7.5
NS 1619 7.5
Equilin 7.5
BNP 7.5
Nitroglycerin 7.4
Sildenafil 7.4
1-phenylethanone 7.4
Butylidenephthalide 7.4
Linalyl acetate 7.4
2-(4-morpholinyl)ethyl 7.3
3H-imidazo[4,5-b]pyridine 7.3
Formycin A 7.3
3H-imidazo[4,5-b]pyridine 7.3
3H-imidazo[4,5-b]pyridine 7.3
Etiocholanolone 7.2
1-phenylethanone 7.2
2-(4-morpholinyl)ethyl 7.2
AA861 7.2
Sodium azide 7.2
3H-imidazo[4,5-b]pyridine 7.2
Ginsenoside Re 7.1
nitric oxide 7.1
2,3-dimercapto-1-propanol 7.0
2,3-dimercapto-1-propanol 7.0
DT3 7.0
Zinc protoporphyrin 7.0
1-EBIO 6.9
Rutaecarpine 6.9
Rutaecarpine 6.9
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