Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.2 (guanylate cyclase)
 8,497 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
guanylate cyclase-activating protein 2 11.9
GUANYLATE CYCLASE 11.9
guanylate cyclase 11.9
guanylate cyclase 1, soluble, beta 3 11.9
guanylyl cyclase 11.9
COD3 11.9
prostaglandin I2 (prostacyclin) receptor 11.9
heat-stable enterotoxin receptor 11.7
GCAP2 11.6
GCAP3 11.5
Guanylate cyclase 11.4
GCAP1 11.3
CORD5 11.3
GUCA1B 11.3
GCAP 11.2
GUCY2D 11.2
retinal degeneration 3 11.1
ROS-GC1 11.1
GC-E 11.0
PRKG1 protein 10.9
guanylate cyclase activating protein 10.9
PDZD3 10.9
SOX25 10.9
G-protein-coupled receptor kinase 1 10.9
guanylin 10.8
GUCA1A 10.8
cGMP-phosphodiesterase activity 10.7
NPR-A 10.7
uroguanylin 10.7
Guanylyl cyclase 10.6
NPR-B 10.6
GUCY1B3 10.5
GC-F 10.5
cGMP-stimulated phosphodiesterase 2 10.3
natriuretic peptide clearance receptor 10.3
GPSM4 10.3
natriuretic peptide receptor A 10.2
natriuretic peptide receptor B 10.2
NPR-C 10.1
D2LIC 9.9
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Disease
COD3 11.9
difficile; Clostridium 11.9
relaxation; bladder 11.9
CORD5 11.3
LCA12 10.9
CORD6 10.1
Chronic idiopathic constipation 10.0
Congenital sodium diarrhea 9.9
Cone dystrophy 9.7
Macular dystrophy 9.3
Multiple carboxylase deficiency 9.1
Central areolar choroidal dystrophy 8.9
CHEST 8.9
Hereditary retinal dystrophies 8.4
Unilateral renal artery stenosis 8.2
dual personality 8.2
NAME 7.5
PAPA 7.2
Biotin deficiency 6.9
PDE 6.9
AGS3 6.8
Retinal degeneration 6.8
NINA 6.6
Persistent pulmonary hypertension 6.5
Flashing 6.4
renin-dependent hypertension 6.4
Pulmonary arterial hypertension 6.4
LCA 6.3
persistent pulmonary hypertension of the newborn 6.2
Pineal gland 5.9
Pineal gland 5.9
Pineal gland 5.9
Myometrium 5.9
cholestatic cirrhosis 5.8
vascular dilation 5.7
RAT 5.6
hypotension and shock 5.4
E. coli septicemia 5.4
Postoperative ileus 5.3
hypertensive cardiomyopathy 5.3
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Symptom
Simple constipation 11.9
Functional abdominal pain 6.4
Functional constipation 6.0
chronic constipation 5.2
bloating 4.5
Lower urinary tract symptoms 4.3
constipation 4.2
Anoxia 3.8
clonus 3.3
bladder pain 3.3
hyperoxia 3.2
loss of balance 3.1
orofacial pain 3.0
hyperesthesia 2.8
abdominal cramps 2.8
despair 2.8
Gastrointestinal symptoms 2.7
angina 2.6
diarrhea 2.6
spasm 2.5
HSA 2.3
acute pain 2.2
general problem 2.1
hypercapnia 1.9
microbial colonization 1.8
colic 1.8
urinary frequency 1.7
exertional dyspnea 1.7
nasal congestion 1.7
analgesia 1.7
skin damage 1.3
polyuria 1.3
photophobia 1.2
flushing 1.2
hypocapnia 1.1
abdominal discomfort 1.1
abdominal pain 0.9
hypothermia 0.8
tense 0.8
polydipsia 0.8
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Drug
N-Hydroxyguanidine 10.3
Carperitide 9.6
Methylene blue 9.3
Sodium nitroprusside 9.3
Nipradilol 8.9
Leminoprazole 8.9
7-Nitroindazole 8.0
Quinaprilat 7.8
Avanafil 7.7
Equilin 7.6
Cicletanine 7.5
Pentaerythritol tetranitrate 7.3
Molsidomine 7.2
L-Homoarginine 7.2
Nitric Oxide 6.9
Viagra 6.7
Viagra 6.6
nitroglycerin 6.5
Regitine 6.5
Gly-Tyr-Gly 6.5
Nesiritide 6.5
Heme 6.2
Nebivolol 6.1
Ergometrine 6.1
PBZ 6.1
Ibudilast 6.0
Batroxobin 5.9
Tegaserod 5.7
Omapatrilat 5.7
Ramelteon 5.6
Ferrous sulfate 5.6
Aminoguanidine 5.5
Timolol maleate 5.4
Tegaserod 5.4
Vardenafil 5.4
Treprostinil 5.4
Quisqualate 5.4
Malonaldehyde 5.2
Glybenclamide 5.2
Iloprost 5.1
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Enzyme
guanylate cyclase 11.9
EC 1.13.11.49 11.9
isoflavone 7-O-glucosyltransferase 9.6
cGMP phosphodiesterase 9.4
PKG 9.4
2-hydroxyisoflavanone dehydratase 9.1
cytidylate cyclase 8.7
retinol isomerase 8.0
2-hydroxyisoflavanone synthase 7.9
NO synthase 7.7
rhodopsin kinase 7.7
lecithin-retinol acyltransferase 7.6
EC 5.3.3.2 7.5
steroid 11beta-hydroxylase 7.5
phosphodiesterase 7.3
NOS 7.0
PDE 6.9
heme oxygenase 6.8
adenylate cyclase 6.6
ecdysone 20-monooxygenase 6.4
protein N-myristoyltransferase 6.3
6-pyruvoyltetrahydropterin synthase 6.3
GMP synthase 6.1
biliverdin reductase 6.1
tyrosylprotein sulfotransferase 6.0
NADPH-diaphorase 6.0
SNO 5.9
carboxypeptidase S 5.7
isoflavone reductase 5.6
protein kinase 5.4
GCA 5.2
lipoxygenase 4.9
lysophosphatidylcholine acyltransferase 4.8
EC 3.6.1.1 4.8
prolinase 4.7
thromboxane synthase 4.7
anthocyanidin synthase 4.7
LipA 4.7
GMP synthetase 4.6
phospholipase C 4.6
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Compound
D-NONOate 11.9
Vindorosine 11.9
5-Nitroisatin 11.9
Tetrahydroneopterin 10.9
8-iso-PGF2beta 10.9
8-Br-cGMP 10.1
8-iso-PGE1 9.7
cGMP 9.6
SB 200646 9.6
C7H9N3O3 9.1
Eudesmin 9.1
Caracemide 9.1
LNO2 9.0
Methylene blue 8.9
Acetylcholine chloride 8.9
3-Chlorotyrosine 8.9
Capillarisin 8.9
8-iso-PGE2 8.6
NPR 8.6
ethanimidamide 8.6
GMP 8.4
Lubiprostone 8.3
Nitroprusside 8.3
D-Arginine 8.3
HM-5 8.3
DEA 8.3
DEA 8.3
DETA 8.2
DEA 8.2
Indicaxanthin 8.2
Isatin 8.1
Sinensetin 8.1
N-(2-hydroxyethyl)nicotinamide 8.1
Cubebin 8.1
C3H7NO2 8.1
Nicorandil 8.0
Sodium bromide 8.0
Lys-vasopressin 8.0
Nitro-L-arginine 8.0
Piloty's acid 7.9
more...