Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.2 (guanylate cyclase)
 8,497 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
guanylate cyclase 6167
guanylyl cyclase 2279
nitric oxide synthase 1585
phosphodiesterase 772
ATP 556
Sep 554
Mol 531
atrial natriuretic peptide 478
natriuretic peptide 474
adenylate cyclase 471
PKG 453
atrial natriuretic factor 391
GTP 345
AMP 309
soluble guanylyl cyclase 282
C-type natriuretic peptide 273
cyclooxygenase 242
calmodulin 235
NPR-A 230
adenylyl cyclase 194
more...
Disease
NAME 646
hypertension 436
pulmonary hypertension 190
heart failure 139
ischemia 138
diabetes 113
cancer 94
pertussis 93
tumor 87
depression 85
PDE 79
atherosclerosis 78
erectile dysfunction 73
stroke 62
congestive heart failure 59
cardiovascular disease 58
neuroblastoma 58
sepsis 47
irritable bowel syndrome 47
sepsis 46
more...
Symptom
diarrhea 93
pain 90
constipation 49
angina 35
analgesia 24
anesthesia 22
seizures 19
abdominal pain 15
headache 14
hyperoxia 13
chronic constipation 13
spasm 11
bloating 10
hypercapnia 8
respiratory distress 8
hypothermia 8
starvation 7
discomfort 6
functional recovery 6
discomfort 6
more...
Drug
nitroglycerin 221
Methylene blue 216
Sodium nitroprusside 160
Cardiovasc 157
Nitric Oxide 81
Heme 60
caffeine 39
ascorbate 36
ROS 32
lysine 31
Indomethacin 30
Angiotensin II 29
CaCl2 26
CaCl2 25
CaCl2 25
Forskolin 24
Nephron 22
Asn 20
ICI 20
NADH 20
more...
Enzyme
guanylate cyclase 8497
protein kinase 911
NO synthase 879
phosphodiesterase 774
adenylate cyclase 482
PKG 453
NOS 257
protein kinase C 214
superoxide dismutase 182
cGMP phosphodiesterase 176
mitogen-activated protein kinase 165
ATPase 156
heme oxygenase 126
phospholipase C 123
catalase 119
PDE 117
thrombin 81
renin 81
lipoxygenase 67
NADPH-diaphorase 65
more...
Compound
cGMP 4328
nitric oxide 3616
arginine 1573
sodium 1387
calcium 1340
GMP 831
cAMP 669
Dec 628
ATP 556
oxygen 385
AMP 350
GTP 348
potassium 329
CO2 276
Clin 243
Methylene blue 241
water 230
cysteine 228
nitrate 203
glutamate 196
more...