Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:4.6.1.2 (guanylate cyclase)
8,497 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein guanylate cyclase 6167 guanylyl cyclase 2279 nitric oxide synthase 1585 phosphodiesterase 772 ATP 556 Sep 554 Mol 531 atrial natriuretic peptide 478 natriuretic peptide 474 adenylate cyclase 471 PKG 453 atrial natriuretic factor 391 GTP 345 AMP 309 soluble guanylyl cyclase 282 C-type natriuretic peptide 273 cyclooxygenase 242 calmodulin 235 NPR-A 230 adenylyl cyclase 194 SIN 193 hemoglobin 190 membrane-bound 190 NPR-B 183 ANP 180 bradykinin 173 superoxide dismutase 168 Guanylate cyclase 161 guanylin 157 neuronal nitric oxide synthase 156 angiotensin II 147 ATPase 146 heme oxygenase-1 138 inducible nitric oxide synthase 133 cGMP phosphodiesterase 133 lipopolysaccharide 131 ADP 130 insulin 123 SNAP 123 catalase 118 endothelial nitric oxide synthase 117 uroguanylin 117 eNOS 110 endothelin-1 108 olfactory 107 GUCY2D 105 collagen 102 ANF 91 vascular endothelium 90 BNP 88 GMP 88 polypeptide 85 GCAP1 83 cytokine 83 thrombin 82 NMDA receptor 82 NPR-C 82 renin 81 CNP 81 PDE 79 Gen 77 NADPH 77 muscarinic receptor 74 PDE5 73 rhodopsin 72 Ang II 71 ROS-GC1 66 lipoxygenase 66 PKA 64 tumor necrosis factor 61 Dictyostelium 60 p38 60 5-hydroxytryptamine 60 GCAP2 59 Guanylyl cyclase 59 vasopressin 58 recoverin 57 HO-1 55 substance P 55 GCAP 54 EDRF 51 calcitonin 49 endothelin receptor 49 vasoactive intestinal peptide 47 tyrosine kinase 45 calcium channel 45 cAMP-dependent protein kinase 45 ERK1 45 SOD 45 neutral endopeptidase 45 gut 44 GABA 44 MAPK 43 endoplasmic reticulum 43 phospholipase A2 43 phosphatase 41 oxytocin 41 CO2 41 guanylyl cyclase C 41 PKC 40 spermatozoa 40 natriuretic peptide receptor A 38 glutamate receptor 37 vasodilator-stimulated phosphoprotein 37 LPS 36 GSH 36 cytochrome P450 36 cyclic nucleotide phosphodiesterase 35 collecting duct 35 GC1 35 ET-1 34 vasoactive intestinal peptide (VIP) 34 ERK 34 cytochrome c 34 beta 1 34 myosin light chain 33 Phosphodiesterase 33 xanthine oxidase 33 interferon-gamma 33 DAF 33 tyrosine hydroxylase 33 SDS 32 NPR 32 ROS 32 brush border 31 caspase-3 31 myoglobin 31 somatostatin 31 mitogen-activated protein 31 GDP 30 HO-2 30 NMR 29 NOC 29 CA1 28 dimeric 28 TNF 28 cystic fibrosis transmembrane conductance regulator 28 Superoxide dismutase 27 Rho 27 vascular endothelial growth factor 27 cytochrome c oxidase 27 albumin 27 glucagon 26 microsomal 26 threonine 26 membrane protein 25 NCS-1 25 serum albumin 25 GTPase 25 PI3K 25 estrogen receptor 25 extracellular signal-regulated kinase 25 axonal 25 ANG 24 cholecystokinin 24 TNF-alpha 24 constitutive nitric oxide synthase 23 cytochrome P-450 22 natriuretic peptide receptor B 22 EFS 22 more...

Disease NAME 646 hypertension 436 pulmonary hypertension 190 heart failure 139 ischemia 138 diabetes 113 cancer 94 pertussis 93 tumor 87 depression 85 PDE 79 atherosclerosis 78 erectile dysfunction 73 stroke 62 congestive heart failure 59 cardiovascular disease 58 neuroblastoma 58 irritable bowel syndrome 47 sepsis 47 sepsis 46 LCA 43 cholera 41 myocardial infarction 41 obesity 38 asthma 37 GSH 36 myocardial ischemia 36 ventricular hypertrophy 34 blindness 32 SDS 32 Pulmonary arterial hypertension 32 Alzheimer's disease 29 vascular disease 29 glioma 24 cirrhosis 23 uterus 23 right heart failure 23 heart disease 23 SEM 23 coronary artery disease 23 pheochromocytoma 22 hypercholesterolemia 21 cold 21 cystic fibrosis 19 tumor growth 19 ATM 19 acute myocardial infarction 18 Blocking 17 hyperglycemia 17 intraocular pressure 15 urethra 15 colorectal cancer 15 inflammatory bowel disease 14 carcinoma 14 hepatic encephalopathy 14 renal disease 14 fits 14 PSS 14 Endothelial dysfunction 14 hepatocellular carcinoma 13 metabolic syndrome 13 Parkinson's disease 13 type 2 diabetes 13 sickle cell disease 13 breast cancer 13 glaucoma 13 malaria 13 aqueous humor 12 chronic renal failure 12 idiopathic thrombocytopenic purpura 12 subarachnoid hemorrhage 12 plaque 12 tetanus 12 retinitis pigmentosa 12 persistent pulmonary hypertension of the newborn 12 portal hypertension 12 carcinogenesis 11 CHEST 11 colitis 11 colon cancer 11 retinopathy 11 melanoma 11 liver disease 11 diabetic nephropathy 10 cognitive impairment 10 Mycobacterium 10 preeclampsia 10 essential hypertension 10 cerebral ischemia 10 chronic obstructive pulmonary disease 10 anaphylaxis 10 fluid overload 9 Yersinia 9 Thoracic 9 proteinuria 9 cardiomyopathy 9 renal failure 9 lung disease 9 Evans 9 adrenocortical carcinoma 9 Tension 8 unstable angina 8 dysplasia 8 chronic pain 8 PAPA 8 schizophrenia 8 West 7 achondroplasia 7 squamous cell carcinoma 7 prostate cancer 7 pulmonary edema 7 amyotrophic lateral sclerosis 7 HIV 7 coronary heart disease 7 type 1 diabetes 7 ureter 7 giant cell arteritis 7 Retinal degeneration 7 leukemia 7 cerebral vasospasm 7 adult respiratory distress syndrome 7 astrocytoma 7 tuberculosis 7 renal impairment 6 impotence 6 PAF 6 ICS 6 osteoporosis 6 gastrointestinal disease 6 liver fibrosis 6 MLC 6 dyspepsia 6 Chronic idiopathic constipation 6 MCF 6 epilepsy 6 gastroparesis 6 adenocarcinoma 6 Frey 6 SMC 6 Pineal 5 neuropathy 5 Luminal 5 achalasia 5 Posterior 5 tumorigenesis 5 Steroids 5 endotoxic shock 5 glomerulosclerosis 5 Adhesion 5 acute renal failure 5 adenoma 5 metastases 5 rheumatoid arthritis 5 bronchopulmonary dysplasia 5 priapism 5 DBA 5 glomerulonephritis 5 malnutrition 5 infectious diseases 5 hypernatremia 4 more...

Symptom diarrhea 93 pain 90 constipation 49 angina 35 analgesia 24 anesthesia 22 seizures 19 abdominal pain 15 headache 14 hyperoxia 13 chronic constipation 13 spasm 11 bloating 10 hypothermia 8 respiratory distress 8 hypercapnia 8 starvation 7 discomfort 6 discomfort 6 collapse 6 functional recovery 6 erythema 5 ataxia 5 acute pain 5 flushing 4 chest pain 4 dyspnea 4 HSA 4 colic 3 despair 3 exertional dyspnea 3 weakness 2 polyuria 2 fatigue 2 Anoxia 2 nausea 2 dystonia 2 clonus 2 orofacial pain 2 acidity 2 hemoptysis 2 tremor 2 dizziness 1 acute stress 1 ENT 1 vertigo 1 tense 1 Simple constipation 1 pelvic pain 1 urinary frequency 1 hyperesthesia 1 wheezing 1 bladder pain 1 microbial colonization 1 syncope 1 bradykinesia 1 Lower urinary tract symptoms 1 hypocapnia 1 back pain 1 arthralgia 1 polydipsia 1 abdominal cramps 1 thinning 1 splenomegaly 1 myalgia 1 abdominal discomfort 1 skin damage 1 memory loss 1 vomiting 1 nasal congestion 1 hunger 1 tinnitus 1 epigastric pain 1 stigma 1 Functional abdominal pain 1 agitation 1 anorexia 1 Functional constipation 1 Gastrointestinal symptoms 1 photophobia 1 loss of balance 1 cough 1 general problem 1

Drug nitroglycerin 221 Methylene blue 216 Sodium nitroprusside 160 Cardiovasc 157 Nitric Oxide 81 Heme 60 caffeine 39 ascorbate 36 ROS 32 lysine 31 Indomethacin 30 Angiotensin II 29 CaCl2 26 CaCl2 25 CaCl2 25 Forskolin 24 Nephron 22 NADH 20 Asn 20 ICI 20 Histamine 19 Ethanol 17 ETA 16 Gel 15 Atropine 15 MAP 15 Viagra 15 Viagra 13 BH4 12 Dermatol 12 CTX 11 IL-2 10 CSF 10 vitamin E 10 IFN-gamma 9 Ouabain 9 Nipradilol 8 PTH 7 FAD 7 EE2 6 Molsidomine 6 Glutathione 6 Fraction 6 7-Nitroindazole 6 Aminoguanidine 5 Amiloride 5 Nebivolol 5 Iloprost 5 Amiloride 5 Theophylline 5 citric acid 5 Luteinizing 4 FeCl3 4 Bayer 4 Nephron 4 Ringer's solution 4 Monit 4 Rolipram 4 CTX 4 Phentolamine 4 Asthma 4 NAG 4 Trifluoperazine 4 Cicletanine 4 CTX 4 Estrogens 4 -deoxyadenosine 3 Dial 3 Pronase 3 Salbutamol 3 Nesiritide 3 Atenolol 3 Clonidine 3 Carperitide 3 ALA 3 lactose 3 ETS 3 Apomorphine 3 Alanine 3 CoCl2 3 NH3 3 CoCl2 3 PCP 3 ZnCl2 2 balanced salt solution 2 Parkin 2 Guanidine 2 EPI 2 Bumetanide 2 Adriamycin 2 Quisqualate 2 Phosphoramidon 2 CIA 2 DMI 2 Simvastatin 2 Adenosine triphosphate 2 niacin 2 Glucagon 2 Kainic acid 2 Cimetidine 2 Emodin 2 Vitamin B 2 Monensin 2 L-tyrosine 2 Guanidine 2 Emodin 2 ZnCl2 2 MgSO4 2 Vardenafil 2 Parkin 2 Cimetidine 2 Leaf 2 Lead acetate 1 Fructose 1 Ranitidine 1 Exenatide 1 L-Homoarginine 1 DNase I 1 Rimonabant 1 Aprotinin 1 Glutamic acid 1 Frontal 1 Ferrous sulfate 1 Lactose 1 Gemfibrozil 1 FLP 1 Tegaserod 1 AHF 1 Dasatinib 1 NBT 1 Quinaprilat 1 Vinpocetine 1 Dronedarone 1 Secretin 1 Scopolamine 1 Malonaldehyde 1 EDR 1 SF6 1 Ibudilast 1 PBZ 1 Nimesulide 1 Tranilast 1 ROC 1 Tegaserod 1 Papaverine 1 Dihydroergotamine 1 Arsenic trioxide 1 Zmax 1 Rutin 1 Tubocurarine 1 Alliance 1 N-Hydroxyguanidine 1 Captopril 1 Myricetin 1 Vitamin E 1 Avanafil 1 Etoposide 1 Portal 1 Cremophor EL 1 Vitamin A 1 more...

Enzyme guanylate cyclase 8497 protein kinase 911 NO synthase 879 phosphodiesterase 774 adenylate cyclase 482 PKG 453 NOS 257 protein kinase C 214 superoxide dismutase 182 cGMP phosphodiesterase 176 mitogen-activated protein kinase 165 ATPase 156 heme oxygenase 126 phospholipase C 123 catalase 119 PDE 117 thrombin 81 renin 81 lipoxygenase 67 NADPH-diaphorase 65 ERK 54 phospholipase A2 53 AMPK 52 CD10 51 calcineurin 37 xanthine oxidase 33 tyrosine hydroxylase 32 MEK 31 ACE 30 NADPH oxidase 29 peroxidase 28 luciferase 27 trypsin 27 caspase-3 26 NADPH oxidase 24 CPT 21 CPT 21 CPT 21 rhodopsin kinase 21 reverse transcriptase 20 AMP-activated protein kinase 19 focal adhesion kinase 18 diaphorase 17 lactate dehydrogenase 17 alkaline phosphatase 16 phosphatidylinositol 3-kinase 16 glutathione S-transferase 15 cytochrome oxidase 14 NQO1 14 CaMKII 14 chymotrypsin 14 RNase 13 myosin light chain kinase 13 diaphorase 13 RNase 13 protein phosphatase 2A 13 aldehyde dehydrogenase 12 aldehyde dehydrogenase 12 collagenase 12 aldehyde dehydrogenase 12 aldehyde dehydrogenase 12 aldehyde dehydrogenase 12 ACS 11 glutathione peroxidase 11 5'-nucleotidase 11 RNA polymerase 11 complex I 10 creatine kinase 10 acetylcholinesterase 10 PAH 9 MAP 9 tyrosinase 8 GSK 8 AMPK 8 carbonic anhydrase 7 arginase 7 PARP 7 lipase 7 proteasome 7 GCA 7 hormone-sensitive lipase 7 glucose oxidase 6 choline acetyltransferase 6 N-acetyltransferase 6 succinate dehydrogenase 6 beta-galactosidase 6 adenosine deaminase 6 nitrite reductase 6 SNO 6 aconitase 6 nitrite reductase 6 transcriptase 6 nitrite reductase 6 ADP-ribosyltransferase 6 ADP-ribosyltransferase 6 adenosine deaminase 6 glucose-6-phosphate dehydrogenase 6 monoamine oxidase 6 glutathione reductase 6 histidine kinase 6 nitrate reductase 5 biliverdin reductase 5 CYP3A4 5 glyceraldehyde-3-phosphate dehydrogenase 5 endoglycosidase H 5 nitrate reductase 5 nitrate reductase 5 caspase-9 5 ribonuclease 5 triphosphatase 5 nitrate reductase 5 nitrate reductase 5 prostaglandin synthetase 5 ribonuclease 5 papain 5 alanine aminotransferase 5 nitrate reductase 5 diacylglycerol kinase 4 CPR 4 thromboxane synthase 4 glyceraldehyde-3-phosphate dehydrogenase 4 phospholipase D 4 lysozyme 4 phosphoinositide 3-kinase 4 GTP cyclohydrolase I 4 glyceraldehyde-3-phosphate dehydrogenase 4 elastase 4 gamma-glutamyl transpeptidase 4 ceruloplasmin 4 chloramphenicol acetyltransferase 4 PTPase 4 caspase-1 4 tissue plasminogen activator 4 MPP 3 aspartate aminotransferase 3 hexokinase 3 DNase 3 glucose-6-phosphatase 3 P-glycoprotein 3 beta-glucuronidase 3 12-lipoxygenase 3 glucokinase 3 15-lipoxygenase 3 cathepsin G 3 argininosuccinate synthetase 3 alcohol dehydrogenase 3 ribonucleotide reductase 3 neuraminidase 3 lipoprotein lipase 3 cytochrome P-450scc 3 cholinesterase 3 ALA synthase 3 glyceraldehyde-3-phosphate dehydrogenase 3 glyceraldehyde-3-phosphate dehydrogenase 3 BAL 3 ribonucleotide reductase 3 citrate synthase 3 apyrase 3 PCP 3 acetyl-CoA carboxylase 3 more...

Compound cGMP 4328 nitric oxide 3616 arginine 1573 sodium 1387 calcium 1340 GMP 831 cAMP 669 Dec 628 ATP 556 oxygen 385 AMP 350 GTP 348 potassium 329 CO2 276 Clin 243 Methylene blue 241 water 230 cysteine 228 nitrate 203 glutamate 196 8-Br-cGMP 187 salt 186 DNA 170 manganese 167 glucose 150 ADP 147 iron 139 noradrenaline 137 prostacyclin 132 ADP 132 ADP 130 acetate 116 Mg2+ 115 hydrogen 114 Cardiol 113 ACh 113 tyrosine 112 adenylate 106 phosphate 105 His 101 NMDA 98 nitrogen 97 BNP 88 aldosterone 81 H2O2 78 NADPH 77 NADPH 77 bromide 72 leucine 69 serine 69 alanine 67 Phe 66 hydroxylamine 65 DEA 64 threonine 64 DEA 64 DEA 64 TEA 63 TEA 63 hydroxylamine 62 sulfate 61 Heme 61 Triton X-100 60 zinc 58 5-HT 56 COS 51 PGE2 49 Sildenafil 48 lysine 47 Nitroglycerin 46 ethanol 46 N-acetylcysteine 45 GABA 44 GABA 44 DETA 42 Off 42 NH2 40 caffeine 39 GSH 39 GSH 39 Bradykinin 39 Ang II 36 Angiotensin II 36 SDS 36 methionine 35 glycerol 34 NO3 34 CIT 34 Nitro-L-arginine 33 prostaglandin E1 33 ammonium 32 NPR 32 nicotinamide 32 DEAE 31 H2S 31 Nitroprusside 31 Nicorandil 30 Isoproterenol 30 GDP 30 Gly 30 Indomethacin 30 Adenosine 29 ornithine 29 ornithine 29 ornithine 29 ornithine 29 ornithine 29 superoxide radical 28 TNF 28 creatinine 28 galactose 28 4-AP 27 cyanide 27 PGE 27 Asp 26 CaCl2 26 PMA 25 AMPA 25 ammonia 25 PMA 24 Forskolin 24 urea 24 Hemoglobin 23 barium 23 carbonate 23 Nitrite 23 Retinal 23 tin 22 Nitrite 22 Insulin 22 Carbachol 22 copper 22 Glibenclamide 21 pyridine 21 Arachidonic acid 21 NAD 21 CPT 21 CPT 21 aspartic acid 21 PEG 20 ACTH 20 ICI 20 NADH 20 tryptophan 19 Guo 19 NAD 19 Histamine 19 Guo 19 Neuronal 19 MEK 19 cobalt 19 Norepinephrine 18 diacetate 18 acetic acid 18 gamma-aminobutyric acid 17 COX 17 DTT 17 Glutamate 17 Dopamine 17 DMSO 17 more...

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