Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.2 (guanylate cyclase)
 8,497 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An increase in the K+ concentration in the medium to 60 mM which causes depolarization of cell membranes in the rat cerebral cortex is studied for its effect on the cGMP level, guanylate cyclase and cGMP phosphodiesterase activities in norm and one hour after X-ray irradiation. The cGMP content and guanylate cyclase activity in normal rats and 1 min after depolarization are shown to increase with the external K+ concentration. One hour after irradiation the activity of enzymes under examination is three times as high. The character of changes in the cGMP content caused by a rise of the external KCP concentration is mainly determined by variations in the guanylate cyclase activity under these conditions.
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PMID:[Metabolism of cGMP with K+ concentration increase in the medium causing depolarization of cortical cell membranes in normal and irradiated rats]. 286 Jul 48