Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We previously isolated a Ca2+-binding protein from a ciliate, Tetrahymena, and designated it as
TCBP
(Tetrahymena Ca2+-binding protein). The present paper reports that
TCBP
, which has two high affinity Ca2+-binding sites (Kd=4.6 X 10(-6) M), could activate porcine brain cyclic nucleotide phosphodiesterase at a concentration of over 10(-6) M free Ca2+, with the same mode of activation as that of authentic (porcine brain) calmodulin. In addition, the amino acid composition of
TCBP
was essentially the same as that of brain calmodulin. Therefore, we conclude that
TCBP
as an activator of Tetrahymena
guanylate cyclase
is indeed a calmodulin.
...
PMID:Tetrahymena calcium-binding protein is indeed a calmodulin. 611 60
