Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of N-(omega-aminoalkyl) derivatives of naphthalene-1-
sulfamide
on the activity of soluble
guanylate cyclase
and on human platelet aggregation at the first (reversible) step of the
guanylate cyclase
reaction was studied. Low (approximately 10(-7)-10(-6) M) concentrations of the above compounds were shown to stimulate the
guanylate cyclase
activity; some derivatives caused simultaneous inhibition of platelet aggregation induced by ADP. Some fragments of the chemical structure of the molecules responsible for the enzyme activity regulation in the tested systems were identified. The naphthalene-1-
sulfamide
derivatives carrying 6-aminohexyl or 8-amino-octyl groups of the
sulfamide
substituent as well as chlorine atom at positions 4 or 5 of the naphthalene ring appeared to be the most potent activators of platelet
guanylate cyclase
and inhibitors of platelet aggregation at the reversible step of the enzymatic reaction.
...
PMID:[Effect of N-(6-aminohexyl)-5-chloronaphthalene-1-sulfamide (W-7) and its analogs on the activity of soluble guanylate cyclase and on human platelet aggregation]. 198 51
