Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Plant pathogens secrete cell wall-degrading enzymes that degrade various components of the plant cell wall. Plants sense this cell wall damage as a mark of infection and induce immune responses. However, the plant functions that are involved in the elaboration of cell wall damage-induced immune responses remain poorly understood. Transcriptome analysis revealed that a rice (
Oryza sativa
) receptor-like kinase,
WALL-ASSOCIATED KINASE-LIKE21
(
OsWAKL21.2
), is up-regulated following treatment with either
Xanthomonas oryzae
pv
oryzae
(a bacterial pathogen) or lipaseA/esterase (
LipA
; a cell wall-degrading enzyme of
X. oryzae
pv
oryzae
). Overexpression of
OsWAKL21.2
in rice induces immune responses similar to those activated by
LipA
treatment. Down-regulation of
OsWAKL21.2
attenuates
LipA
-mediated immune responses. Heterologous expression of
OsWAKL21.2
in Arabidopsis (
Arabidopsis thaliana
) also activates plant immune responses. OsWAKL21.2 is a dual-activity kinase that has in vitro kinase and
guanylate cyclase
activities. Interestingly, kinase activity of OsWAKL21.2 is necessary to activate rice immune responses, whereas in Arabidopsis, OsWAKL21.2
guanylate cyclase
activity activates these responses. Our study reveals a rice receptor kinase that activates immune responses in two different species via two different mechanisms.
...
PMID:Dual Activities of Receptor-Like Kinase OsWAKL21.2 Induce Immune Responses. 3235 78
