Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of
tyrosine aminotransferase
(
TAT
) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1-10 mM) causes a two- to five-fold increase in intracellular cAMP concentration but a 30-60% decrease in cGMP concentration. The decrease in cGMP occurs at doses of theophylline which increase the rate of
TAT
degradation. When cGMP levels are increased by incubating the cells with either Mn2+, an activator of
guanylate cyclase
, or 8-bromo-cGMP, an analog of cGMP, the effect of theophylline is reversed and the rate of
TAT
degradation is slowed. Thus, the rate of
TAT
degradation is inversely related to the concentration of cGMP in HTC cells. This raises the possibility that a cGMP-dependent event is involved in the control of specific protein degradation.
...
PMID:The involvement of cyclic GMP in tyrosine aminotransferase degradation in rat hepatoma tissue culture cells. 611 61
