Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The food coloring amaranth (F, D and C red No. 2) and the red pigment carmine, but not erythrosine (F, D and C red No. 3), caused a twofold enhancement of two enzymes (
aryl hydrocarbon hydroxylase
and
guanylate cyclase
) that have been linked with chemical carcinogenesis. Dose response relationships revealed that carmine enhanced both enzymes to near maximal levels at concentrations as low as 1 to 10 nM while amaranth needed a concentration of 100 nM to cause a maximal enhancement. These data suggest that amaranth and carmine mimic the effects of some chemical carcinogens at the cellular level, but erythrosine does not mimic any of these effects.
...
PMID:Red dye No. 2 and the red pigment carmine enhance aryl hydrocarbon hydroxylase and guanylate cyclase activities. 613 3
