Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.2 (
guanylate cyclase
)
8,497
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. The
roundworm
Caenorhabditis elegans
avoids 21% O
2
and hypoxia and prefers intermediate O
2
concentrations. We show how this O
2
preference is sculpted by the antagonistic action of a neuroglobin and an O
2
-binding soluble
guanylate cyclase
. These putative molecular O
2
sensors confer a sigmoidal O
2
response curve in the URX neurons that has highest slope between 15 and 19% O
2
and approaches saturation when O
2
reaches 21%. In the absence of the neuroglobin, the response curve is shifted to lower O
2
values and approaches saturation at 14% O
2
In behavioral terms, neuroglobin signaling broadens the O
2
preference of
Caenorhabditis elegans
while maintaining avoidance of 21% O
2
A computational model of aerotaxis suggests the relationship between GLB-5-modulated URX responses and reversal behavior is sufficient to broaden O
2
preference. In summary, we show that a neuroglobin can shift neural information coding leading to altered behavior. Antagonistically acting molecular sensors may represent a common mechanism to sharpen tuning of sensory neurons.
...
PMID:Modulation of sensory information processing by a neuroglobin in
Caenorhabditis elegans
. 2853
