Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
adenylate cyclase
18122
AMP
3740
phosphodiesterase
1777
GTP
1741
Sep
1330
Mol
1257
ATP
1080
adenyl cyclase
894
glucagon
854
ADP
787
insulin
708
calmodulin
686
parathyroid hormone
562
vasoactive intestinal peptide
502
guanylate cyclase
464
polypeptide
454
vasopressin
442
somatostatin
426
calcitonin
422
cAMP-dependent protein kinase
421
ATPase
417
vasoactive intestinal peptide (VIP)
396
ACTH
348
membrane-bound
333
pituitary adenylate cyclase-activating polypeptide
328
PKA
312
GDP
304
beta-endorphin
298
PTH
283
secretin
273
beta 1
249
adenosine receptor
244
GTP-binding protein
242
GTPase
221
VIP
197
membrane protein
188
ATP pyrophosphate-lyase
186
thrombin
181
cyclic AMP phosphodiesterase
181
substance P
178
angiotensin II
177
prolactin
173
collagen
173
FSH
169
guanine nucleotide regulatory protein
168
5-hydroxytryptamine
167
PKC
166
olfactory
165
SCH
161
alkaline phosphatase
161
nitric oxide synthase
160
muscarinic receptor
158
NAD
152
cyclooxygenase
152
guanine nucleotide-binding protein
146
Gen
146
cyclic nucleotide phosphodiesterase
144
adenosine deaminase
140
cytokine
137
adenylyl cyclase
133
arginine vasopressin
132
GMP
131
growth hormone
126
bradykinin
123
phospholipase A2
123
guanine nucleotide binding protein
119
neuropeptide Y
116
tyrosine kinase
116
GABA
116
PACAP
115
osteosarcoma
115
5-HT1A
113
epidermal growth factor
112
chorionic gonadotropin
111
tyrosine hydroxylase
110
glycoprotein
110
opioid receptor
109
collagenase
108
5'-nucleotidase
107
GHRH
106
more...
Disease
pertussis
1771
cholera
1352
Bordetella
545
tumor
456
neuroblastoma
282
cancer
278
glioma
221
diabetes
214
depression
198
lymphoma
185
SCH
161
Pituitary
155
hypertension
151
osteosarcoma
136
heart failure
132
ischemia
117
Graves' disease
116
SDS
91
asthma
90
melanoma
85
pheochromocytoma
80
cold
77
carcinoma
76
hypothyroidism
72
PDE
72
pseudohypoparathyroidism
70
hyperthyroidism
70
uterus
66
obesity
66
NAME
66
SEM
63
chronic renal failure
63
astrocytoma
57
hypercalcemia
56
Alzheimer's disease
56
hepatocellular carcinoma
54
anthrax
53
congestive heart failure
52
breast cancer
51
type 2 diabetes
50
APC
49
intraocular pressure
47
leukemia
47
schizophrenia
45
hyperglycemia
43
stroke
42
migraine
42
adenocarcinoma
42
Parkinson's disease
38
cystic fibrosis
38
atherosclerosis
36
goiter
36
adenoma
36
sympathomimetic
35
pituitary tumor
35
myocardial infarction
33
myocardial ischemia
32
tumor growth
32
idiopathic thrombocytopenic purpura
31
cardiomyopathy
30
hyperparathyroidism
30
infectious diseases
30
insulinoma
29
erythroleukemia
29
aqueous humor
25
sarcoma
24
SMS
24
Mycobacterium
24
carcinogenesis
24
MCF
23
essential hypertension
23
dilated cardiomyopathy
23
nephrogenic diabetes insipidus
23
bipolar disorder
22
plaque
22
hyperinsulinemia
21
hypoglycemia
21
metastases
21
uremia
21
prostate cancer
21
more...
Symptom
pain
74
diarrhea
71
starvation
65
seizures
32
analgesia
30
anesthesia
29
hypothermia
27
headache
25
vomiting
16
polyuria
14
tremor
13
fatigue
9
collapse
9
functional recovery
8
anorexia
8
cachexia
8
insomnia
7
exhaustion
7
twitching
7
acute stress
5
constipation
5
respiratory distress
5
acidity
4
memory loss
4
erythema
4
dry eye
4
polydipsia
4
agitation
4
angina
4
cough
4
Anoxia
4
dyspnea
3
hunger
3
weakness
3
spasm
3
incoordination
3
thinning
3
syncope
3
acute pain
3
hypercapnia
3
stigma
3
nausea
3
dystonia
2
Ill
2
ataxia
2
vertigo
2
flushing
2
rundown
2
nausea and vomiting
2
chest pain
2
Catch
2
hyperemesis gravidarum
2
eds
2
clonus
2
Decreased activity
2
myalgia
2
HSA
2
spasticity
2
sleepiness
1
sinus pain
1
despair
1
dysosmia
1
bitter taste
1
POA
1
enuresis
1
skin pain
1
Neuropathic pain
1
fasciculation
1
emaciation
1
hypocapnia
1
general problem
1
autodigestion
1
nasal congestion
1
ENT
1
exertional dyspnea
1
cerebellar ataxia
1
chronic constipation
1
Welt
1
pelvic pain
1
apathy
1
more...
Drug
Forskolin
814
PTH
284
Glucagon
152
Cardiovasc
135
Nephron
128
caffeine
126
ICI
118
Histamine
114
Dermatol
110
lysine
92
MAP
57
Theophylline
54
Ethanol
53
ROS
52
Clonidine
50
GRF
48
Angiotensin II
46
Indomethacin
45
Gel
45
Secretin
43
IL-2
35
CaCl2
34
CaCl2
34
CaCl2
34
-deoxyadenosine
33
lactose
31
Iloprost
29
Atropine
29
Trifluoperazine
28
9-THC
28
ACT
27
IFN-gamma
27
Asn
24
EE2
24
Ouabain
23
Rolipram
22
Apomorphine
22
NADH
22
Sulpiride
18
Sodium nitroprusside
18
ascorbate
17
Phentolamine
16
CSF
16
ETA
15
Salbutamol
15
Luteinizing
14
CTX
14
nitroglycerin
13
Retinoic acid
13
MgSO4
13
Ringer's solution
12
Adenosine deaminase
12
Cimetidine
12
Cimetidine
11
vitamin E
11
Glycerol
10
Papaverine
10
Butaprost
10
niacin
10
Alprenolol
9
Salmon calcitonin
9
Alanine
8
Nephron
8
HCG
8
Monensin
8
Leaf
8
Amiloride
7
Reserpine
7
DHT
7
CTX
7
DHT
7
DNase I
7
Methylene blue
7
NAG
7
CTX
7
Fenoldopam
7
Clofibrate
6
DEX
6
NaI
6
DDAVP
6
more...
Enzyme
adenylate cyclase
19190
protein kinase
2106
phosphodiesterase
1785
protein kinase C
1115
phospholipase C
710
guanylate cyclase
482
ATPase
472
AMPK
434
mitogen-activated protein kinase
315
PDE
237
thrombin
177
alkaline phosphatase
164
trypsin
156
phospholipase A2
148
adenosine deaminase
141
adenosine deaminase
140
ERK
111
5'-nucleotidase
110
collagenase
108
tyrosine hydroxylase
105
phosphorylase
87
renin
81
calcineurin
78
luciferase
75
MEK
75
cGMP phosphodiesterase
74
acetylcholinesterase
55
NO synthase
53
chymotrypsin
47
peroxidase
46
RNA polymerase
43
monoamine oxidase
42
CPT
42
CPT
41
CPT
41
lipase
40
reverse transcriptase
38
acid phosphatase
38
phospholipase D
38
beta-galactosidase
37
lipoxygenase
37
choline acetyltransferase
36
phosphatidylinositol 3-kinase
35
lactate dehydrogenase
35
PARP
34
CaMKII
33
ADP-ribosyltransferase
33
ADP-ribosyltransferase
32
glucose-6-phosphatase
31
catalase
30
RNase
30
PKG
30
N-acetyltransferase
30
RNase
30
creatine kinase
29
Mg2+-ATPase
29
focal adhesion kinase
29
ornithine decarboxylase
27
NADPH oxidase
26
chloramphenicol acetyltransferase
25
carbonic anhydrase
24
AMP-activated protein kinase
24
hormone-sensitive lipase
23
alcohol dehydrogenase
23
NADPH oxidase
22
tyrosinase
21
myosin light chain kinase
20
VIP1
20
pyruvate kinase
20
triphosphatase
20
caspase-3
20
superoxide dismutase
19
MAP
19
ADH
19
phosphoenolpyruvate carboxykinase
19
neuraminidase
18
proteasome
18
histidine decarboxylase
17
CPR
17
glutathione S-transferase
17
more...
Compound
cAMP
5820
AMP
4358
calcium
2897
GTP
1754
Dec
1358
sodium
1332
ATP
1082
ADP
843
Forskolin
819
prostaglandin E1
808
Clin
797
ADP
793
ADP
792
glucose
783
acetate
691
cGMP
678
DNA
592
phosphate
584
Mg2+
470
noradrenaline
461
adenylate
452
water
393
PGE2
391
TSH
364
prostacyclin
359
GDP
358
potassium
355
ACTH
350
Isoproterenol
332
arginine
312
manganese
300
5-HT
291
Adenosine
291
nitric oxide
280
tyrosine
249
GMP
242
Dopamine
218
NAD
211
glutamate
204
sulfate
196
ethanol
185
oxygen
173
PGE
171
Adrenal
165
lysine
157
leucine
154
NAD
152
Glucagon
152
Phe
147
NH2
145
His
140
iodine
135
alanine
132
glycerol
130
Insulin
127
caffeine
126
serine
125
salt
121
methionine
119
GABA
118
ICI
118
GABA
118
Norepinephrine
116
Histamine
114
galactose
106
PMA
106
Cardiol
105
PMA
105
SDS
103
ACh
102
aldosterone
102
TPA
96
TPA
96
threonine
90
urea
88
COS
87
EDTA
85
EDTA
85
Gly
84
PGD2
83
more...