Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
adenylate cyclase
18122
AMP
3740
phosphodiesterase
1777
GTP
1741
Sep
1330
Mol
1257
ATP
1080
adenyl cyclase
894
glucagon
854
ADP
787
insulin
708
calmodulin
686
parathyroid hormone
562
vasoactive intestinal peptide
502
guanylate cyclase
464
polypeptide
454
vasopressin
442
somatostatin
426
calcitonin
422
cAMP-dependent protein kinase
421
ATPase
417
vasoactive intestinal peptide (VIP)
396
ACTH
348
membrane-bound
333
pituitary adenylate cyclase-activating polypeptide
328
PKA
312
GDP
304
beta-endorphin
298
PTH
283
secretin
273
beta 1
249
adenosine receptor
244
GTP-binding protein
242
GTPase
221
VIP
197
membrane protein
188
ATP pyrophosphate-lyase
186
thrombin
181
cyclic AMP phosphodiesterase
181
substance P
178
more...
Disease
pertussis
1771
cholera
1352
Bordetella
545
tumor
456
neuroblastoma
282
cancer
278
glioma
221
diabetes
214
depression
198
lymphoma
185
SCH
161
Pituitary
155
hypertension
151
osteosarcoma
136
heart failure
132
ischemia
117
Graves' disease
116
SDS
91
asthma
90
melanoma
85
pheochromocytoma
80
cold
77
carcinoma
76
PDE
72
hypothyroidism
72
pseudohypoparathyroidism
70
hyperthyroidism
70
obesity
66
NAME
66
uterus
66
chronic renal failure
63
SEM
63
astrocytoma
57
hypercalcemia
56
Alzheimer's disease
56
hepatocellular carcinoma
54
anthrax
53
congestive heart failure
52
breast cancer
51
type 2 diabetes
50
more...
Symptom
pain
74
diarrhea
71
starvation
65
seizures
32
analgesia
30
anesthesia
29
hypothermia
27
headache
25
vomiting
16
polyuria
14
tremor
13
collapse
9
fatigue
9
functional recovery
8
anorexia
8
cachexia
8
insomnia
7
twitching
7
exhaustion
7
constipation
5
respiratory distress
5
acute stress
5
acidity
4
dry eye
4
cough
4
erythema
4
angina
4
memory loss
4
agitation
4
Anoxia
4
polydipsia
4
stigma
3
weakness
3
incoordination
3
dyspnea
3
thinning
3
hunger
3
spasm
3
acute pain
3
hypercapnia
3
more...
Drug
Forskolin
814
PTH
284
Glucagon
152
Cardiovasc
135
Nephron
128
caffeine
126
ICI
118
Histamine
114
Dermatol
110
lysine
92
MAP
57
Theophylline
54
Ethanol
53
ROS
52
Clonidine
50
GRF
48
Angiotensin II
46
Gel
45
Indomethacin
45
Secretin
43
IL-2
35
CaCl2
34
CaCl2
34
CaCl2
34
-deoxyadenosine
33
lactose
31
Iloprost
29
Atropine
29
Trifluoperazine
28
9-THC
28
ACT
27
IFN-gamma
27
Asn
24
EE2
24
Ouabain
23
NADH
22
Rolipram
22
Apomorphine
22
Sulpiride
18
Sodium nitroprusside
18
more...
Enzyme
adenylate cyclase
19190
protein kinase
2106
phosphodiesterase
1785
protein kinase C
1115
phospholipase C
710
guanylate cyclase
482
ATPase
472
AMPK
434
mitogen-activated protein kinase
315
PDE
237
thrombin
177
alkaline phosphatase
164
trypsin
156
phospholipase A2
148
adenosine deaminase
141
adenosine deaminase
140
ERK
111
5'-nucleotidase
110
collagenase
108
tyrosine hydroxylase
105
phosphorylase
87
renin
81
calcineurin
78
luciferase
75
MEK
75
cGMP phosphodiesterase
74
acetylcholinesterase
55
NO synthase
53
chymotrypsin
47
peroxidase
46
RNA polymerase
43
monoamine oxidase
42
CPT
42
CPT
41
CPT
41
lipase
40
acid phosphatase
38
phospholipase D
38
reverse transcriptase
38
lipoxygenase
37
more...
Compound
cAMP
5820
AMP
4358
calcium
2897
GTP
1754
Dec
1358
sodium
1332
ATP
1082
ADP
843
Forskolin
819
prostaglandin E1
808
Clin
797
ADP
793
ADP
792
glucose
783
acetate
691
cGMP
678
DNA
592
phosphate
584
Mg2+
470
noradrenaline
461
adenylate
452
water
393
PGE2
391
TSH
364
prostacyclin
359
GDP
358
potassium
355
ACTH
350
Isoproterenol
332
arginine
312
manganese
300
5-HT
291
Adenosine
291
nitric oxide
280
tyrosine
249
GMP
242
Dopamine
218
NAD
211
glutamate
204
sulfate
196
more...