Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:4.6.1.1 (adenylate cyclase)
19,190 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein adenylate cyclase 18122 AMP 3740 phosphodiesterase 1777 GTP 1741 Sep 1330 Mol 1257 ATP 1080 adenyl cyclase 894 glucagon 854 ADP 787 insulin 708 calmodulin 686 parathyroid hormone 562 vasoactive intestinal peptide 502 guanylate cyclase 464 polypeptide 454 vasopressin 442 somatostatin 426 calcitonin 422 cAMP-dependent protein kinase 421 ATPase 417 vasoactive intestinal peptide (VIP) 396 ACTH 348 membrane-bound 333 pituitary adenylate cyclase-activating polypeptide 328 PKA 312 GDP 304 beta-endorphin 298 PTH 283 secretin 273 beta 1 249 adenosine receptor 244 GTP-binding protein 242 GTPase 221 VIP 197 membrane protein 188 ATP pyrophosphate-lyase 186 thrombin 181 cyclic AMP phosphodiesterase 181 substance P 178 angiotensin II 177 collagen 173 prolactin 173 FSH 169 guanine nucleotide regulatory protein 168 5-hydroxytryptamine 167 PKC 166 olfactory 165 alkaline phosphatase 161 SCH 161 nitric oxide synthase 160 muscarinic receptor 158 cyclooxygenase 152 NAD 152 guanine nucleotide-binding protein 146 Gen 146 cyclic nucleotide phosphodiesterase 144 adenosine deaminase 140 cytokine 137 adenylyl cyclase 133 arginine vasopressin 132 GMP 131 growth hormone 126 bradykinin 123 phospholipase A2 123 guanine nucleotide binding protein 119 GABA 116 tyrosine kinase 116 neuropeptide Y 116 osteosarcoma 115 PACAP 115 5-HT1A 113 epidermal growth factor 112 chorionic gonadotropin 111 tyrosine hydroxylase 110 glycoprotein 110 opioid receptor 109 collagenase 108 5'-nucleotidase 107 GHRH 106 calcium channel 105 SRIF 104 corticotropin-releasing factor 102 PACAP receptor 97 TPA 96 lipopolysaccharide 96 Dictyostelium 94 microsomal 93 G protein-coupled receptor 92 SDS 91 cholecystokinin 91 parathyroid hormone-related protein 91 PAC1 90 fused 89 ras 88 hormone receptor 88 endoplasmic reticulum 86 MAPK 85 Vasoactive intestinal peptide 85 Parathyroid hormone 85 renin 81 gut 81 proximal tubule 81 ERK 80 CREB 79 galanin 78 phosphatase 76 phospholipase 75 PGD2 75 adenosine A1 receptor 75 oxytocin 74 Aplysia 74 epididymal 73 PDE 72 gastrin 71 EP2 70 ERK1 68 glucagon receptor 68 follicle-stimulating hormone 67 VPAC1 67 p38 66 Calcitonin 66 PLC 65 EP4 64 thyroid hormone 64 TRH 64 protein kinase C inhibitor 63 VPAC2 63 CA1 63 Ang II 63 protein kinase inhibitor 62 CD11b 62 atrial natriuretic factor 61 NAD+ 61 adenylate cyclase-coupled 60 rhodopsin 60 PNP 59 G-protein-coupled receptor 59 nerve growth factor 58 EP3 58 5-HT receptor 57 collecting duct 57 prostaglandin I2 57 MAP kinase 56 AVP 56 PRL 55 c-fos 55 LHRH 55 PK1 54 MEK 54 adrenocorticotropic hormone 53 lectin 53 cannabinoid receptor 53 inhibitor 2 53 Leu5 52 ROS 52 acetylcholinesterase 52 IL-6 52 Leydig cell 51 tumor necrosis factor 51 more...

Disease pertussis 1771 cholera 1352 Bordetella 545 tumor 456 neuroblastoma 282 cancer 278 glioma 221 diabetes 214 depression 198 lymphoma 185 SCH 161 Pituitary 155 hypertension 151 osteosarcoma 136 heart failure 132 ischemia 117 Graves' disease 116 SDS 91 asthma 90 melanoma 85 pheochromocytoma 80 cold 77 carcinoma 76 hypothyroidism 72 PDE 72 pseudohypoparathyroidism 70 hyperthyroidism 70 uterus 66 obesity 66 NAME 66 chronic renal failure 63 SEM 63 astrocytoma 57 hypercalcemia 56 Alzheimer's disease 56 hepatocellular carcinoma 54 anthrax 53 congestive heart failure 52 breast cancer 51 type 2 diabetes 50 APC 49 intraocular pressure 47 leukemia 47 schizophrenia 45 hyperglycemia 43 adenocarcinoma 42 stroke 42 migraine 42 cystic fibrosis 38 Parkinson's disease 38 adenoma 36 goiter 36 atherosclerosis 36 sympathomimetic 35 pituitary tumor 35 myocardial infarction 33 tumor growth 32 myocardial ischemia 32 idiopathic thrombocytopenic purpura 31 cardiomyopathy 30 hyperparathyroidism 30 infectious diseases 30 erythroleukemia 29 insulinoma 29 aqueous humor 25 carcinogenesis 24 sarcoma 24 SMS 24 Mycobacterium 24 nephrogenic diabetes insipidus 23 MCF 23 dilated cardiomyopathy 23 essential hypertension 23 bipolar disorder 22 plaque 22 prostate cancer 21 hypoglycemia 21 metastases 21 uremia 21 hyperinsulinemia 21 Infection 21 tuberculosis 20 phosphaturia 20 ICS 20 sepsis 20 addiction 20 ADH 19 Blocking 19 ATM 19 psoriasis 19 dehydration 18 Yersinia 18 PAF 18 pulmonary hypertension 18 diabetes insipidus 18 sepsis 17 osteoporosis 17 hypoparathyroidism 17 alcoholism 17 choriocarcinoma 17 catalepsy 17 adrenocortical carcinoma 16 Dissociation 16 diphtheria 16 acromegaly 16 cerebral ischemia 16 thyroiditis 15 hypercalcemia of malignancy 15 HIV 15 Evans 15 Hashimoto's thyroiditis 14 colon cancer 14 squamous cell carcinoma 14 lung cancer 14 Steroids 14 mastocytoma 14 Neuroblastoma 14 tardive dyskinesia 14 Neuroblastoma 14 peptic ulcer 14 immunodeficiency 13 glucose intolerance 13 malnutrition 13 renal disease 13 THC 13 Leydig cell tumor 12 MAS 12 idiopathic dilated cardiomyopathy 12 varices 12 ureter 12 dysplasia 12 renal cell carcinoma 12 ventricular hypertrophy 12 epididymis 12 AIDS 12 precocious puberty 12 epilepsy 12 chronic obstructive pulmonary disease 12 thyrotoxicosis 11 Cushing's syndrome 11 Rous sarcoma 11 tetanus 11 aggression 11 mania 11 tumor progression 11 carcinoid 11 drug withdrawal 11 tumorigenesis 11 Schistosoma mansoni 11 cornea 11 renal failure 11 embryonal carcinoma 11 Pineal 11 PHA 11 myxedema 11 vitamin D deficiency 11 rheumatoid arthritis 11 Brown 11 stereotypies 11 cardiovascular disease 10 more...

Symptom pain 74 diarrhea 71 starvation 65 seizures 32 analgesia 30 anesthesia 29 hypothermia 27 headache 25 vomiting 16 polyuria 14 tremor 13 collapse 9 fatigue 9 cachexia 8 anorexia 8 functional recovery 8 insomnia 7 twitching 7 exhaustion 7 acute stress 5 respiratory distress 5 constipation 5 acidity 4 memory loss 4 dry eye 4 polydipsia 4 cough 4 Anoxia 4 erythema 4 angina 4 agitation 4 dyspnea 3 weakness 3 spasm 3 hypercapnia 3 thinning 3 acute pain 3 incoordination 3 stigma 3 hunger 3 syncope 3 nausea 3 dystonia 2 Ill 2 ataxia 2 vertigo 2 flushing 2 rundown 2 myalgia 2 hyperemesis gravidarum 2 chest pain 2 Catch 2 eds 2 clonus 2 Decreased activity 2 HSA 2 nausea and vomiting 2 spasticity 2 sleepiness 1 sinus pain 1 despair 1 dysosmia 1 bitter taste 1 POA 1 enuresis 1 skin pain 1 Neuropathic pain 1 fasciculation 1 emaciation 1 hypocapnia 1 hemoptysis 1 general problem 1 hepatomegaly 1 cancer pain 1 exertional dyspnea 1 cerebellar ataxia 1 nasal congestion 1 overweight 1 chronic constipation 1 hypoproteinemia 1 autodigestion 1 bone pain 1 ENT 1 Welt 1 urinary frequency 1 apathy 1 leg cramps 1 photopsia 1 photophobia 1 Gastrointestinal symptoms 1 anosmia 1 Excitability 1 decreased appetite 1 dry skin 1 pelvic pain 1 dizziness 1 arthralgia 1 Orthostasis 1 regurgitation 1 DNA marker 1 ketonuria 1 rhinorrhea 1

Drug Forskolin 814 PTH 284 Glucagon 152 Cardiovasc 135 Nephron 128 caffeine 126 ICI 118 Histamine 114 Dermatol 110 lysine 92 MAP 57 Theophylline 54 Ethanol 53 ROS 52 Clonidine 50 GRF 48 Angiotensin II 46 Indomethacin 45 Gel 45 Secretin 43 IL-2 35 CaCl2 34 CaCl2 34 CaCl2 34 -deoxyadenosine 33 lactose 31 Iloprost 29 Atropine 29 Trifluoperazine 28 9-THC 28 IFN-gamma 27 ACT 27 EE2 24 Asn 24 Ouabain 23 NADH 22 Rolipram 22 Apomorphine 22 Sodium nitroprusside 18 Sulpiride 18 ascorbate 17 Phentolamine 16 CSF 16 ETA 15 Salbutamol 15 Luteinizing 14 CTX 14 nitroglycerin 13 MgSO4 13 Retinoic acid 13 Ringer's solution 12 Cimetidine 12 Adenosine deaminase 12 Cimetidine 11 vitamin E 11 niacin 10 Papaverine 10 Glycerol 10 Butaprost 10 Alprenolol 9 Salmon calcitonin 9 HCG 8 Monensin 8 Alanine 8 Leaf 8 Nephron 8 Fenoldopam 7 Methylene blue 7 DHT 7 DNase I 7 Amiloride 7 CTX 7 NAG 7 DHT 7 Reserpine 7 CTX 7 DDAVP 6 NaI 6 NaI 6 DDAVP 6 AC2 6 Amiloride 6 Portal 6 balanced salt solution 6 NaI 6 Fraction 6 NaI 6 Ranitidine 6 Clofibrate 6 DEX 6 Growth hormone 5 CoCl2 5 Lisuride 5 Phosphatidylserine 5 Timolol 5 Pitressin 5 Sulprostone 5 Growth hormone 5 Mutagen 5 DMI 5 CoCl2 5 Hypaque 4 Hypaque 4 K-252a 4 Atenolol 4 G418 4 Pronase 4 APD 4 Aprotinin 4 Ketoconazole 4 Beraprost 4 Flupenthixol 4 PCP 4 Fluphenazine 4 ABC 4 Deoxyadenosine 4 Fructose 4 Thyroglobulin 4 Asthma 4 Cilostazol 4 2'-Deoxyadenosine 3 PTC 3 ZnCl2 3 Spiegel 3 Kenyan 3 Gastro 3 Bumetanide 3 DFP 3 Tubocurarine 3 Kainic acid 3 Pregnenolone 3 CAM 3 Penfluridol 3 Vitamin E 3 Enprofylline 3 Denopamine 3 Monit 3 Fenoterol 3 Ketotifen 3 linolenate 3 CDP 3 ZnCl2 3 Activin 3 EPI 3 Fentanyl 3 Prednisolone 3 Diurnal 3 Enprostil 3 Scopolamine 2 PMEA 2 MRC 2 Indapamide 2 ISP 2 Remoxipride 2 FAD 2 Parlodel 2 THF 2 Captopril 2 ROC 2 Liraglutide 2 more...

Enzyme adenylate cyclase 19190 protein kinase 2106 phosphodiesterase 1785 protein kinase C 1115 phospholipase C 710 guanylate cyclase 482 ATPase 472 AMPK 434 mitogen-activated protein kinase 315 PDE 237 thrombin 177 alkaline phosphatase 164 trypsin 156 phospholipase A2 148 adenosine deaminase 141 adenosine deaminase 140 ERK 111 5'-nucleotidase 110 collagenase 108 tyrosine hydroxylase 105 phosphorylase 87 renin 81 calcineurin 78 MEK 75 luciferase 75 cGMP phosphodiesterase 74 acetylcholinesterase 55 NO synthase 53 chymotrypsin 47 peroxidase 46 RNA polymerase 43 monoamine oxidase 42 CPT 42 CPT 41 CPT 41 lipase 40 acid phosphatase 38 reverse transcriptase 38 phospholipase D 38 beta-galactosidase 37 lipoxygenase 37 choline acetyltransferase 36 phosphatidylinositol 3-kinase 35 lactate dehydrogenase 35 PARP 34 CaMKII 33 ADP-ribosyltransferase 33 ADP-ribosyltransferase 32 glucose-6-phosphatase 31 RNase 30 catalase 30 N-acetyltransferase 30 PKG 30 RNase 30 Mg2+-ATPase 29 focal adhesion kinase 29 creatine kinase 29 ornithine decarboxylase 27 NADPH oxidase 26 chloramphenicol acetyltransferase 25 AMP-activated protein kinase 24 carbonic anhydrase 24 hormone-sensitive lipase 23 alcohol dehydrogenase 23 NADPH oxidase 22 tyrosinase 21 VIP1 20 pyruvate kinase 20 triphosphatase 20 myosin light chain kinase 20 caspase-3 20 superoxide dismutase 19 ADH 19 phosphoenolpyruvate carboxykinase 19 MAP 19 neuraminidase 18 proteasome 18 glutathione S-transferase 17 CPR 17 urokinase-type plasminogen activator 17 lipoprotein lipase 17 phosphoenolpyruvate carboxykinase 17 phosphoenolpyruvate carboxykinase 17 histidine decarboxylase 17 arylalkylamine N-acetyltransferase 16 transcriptase 16 succinate dehydrogenase 16 PI-PLC 16 NOS 16 beta-glucuronidase 15 glucose-6-phosphate dehydrogenase 15 GSK 14 phosphorylase kinase 14 GRK2 14 elastase 14 nucleotidase 14 NAD glycohydrolase 14 ATP synthase 14 diaphorase 13 pepsin 13 phosphoinositide 3-kinase 13 APC 12 gamma-glutamyl transpeptidase 12 furin 12 thyroid peroxidase 12 adenosine kinase 12 tissue plasminogen activator 11 apyrase 11 leucine aminopeptidase 11 trehalase 11 aequorin 11 CD10 10 ACS 10 ribonuclease 10 ribonuclease 10 AMPK 10 hyaluronidase 10 histidine kinase 10 thymidine kinase 10 invertase 10 lysozyme 10 prostaglandin synthetase 10 papain 10 malate dehydrogenase 9 phosphofructokinase 9 HSD 9 pyruvate dehydrogenase 9 tryptophanase 9 cholesterol esterase 9 hexosaminidase 9 CD13 9 glutamate decarboxylase 9 xanthine oxidase 9 glucokinase 9 tryptophan 2,3-dioxygenase 9 ACE 9 p-nitrophenylphosphatase 9 subtilisin 8 glyceraldehyde-3-phosphate dehydrogenase 8 pyruvate dehydrogenase 8 alanine aminotransferase 8 deaminase 8 transglutaminase 8 succinic dehydrogenase 8 hexokinase 8 hyaluronidase 8 plasmin 8 cytochrome oxidase 8 tryptophan hydroxylase 8 pyruvate dehydrogenase 8 glutamine synthetase 8 adenylate kinase 7 heme oxygenase 7 isocitrate dehydrogenase 7 caspase-1 7 GRK5 7 aldehyde dehydrogenase 7 thromboxane synthase 7 cdc2 6 6-phosphofructo-2-kinase 6 more...

Compound cAMP 5820 AMP 4358 calcium 2897 GTP 1754 Dec 1358 sodium 1332 ATP 1082 ADP 843 Forskolin 819 prostaglandin E1 808 Clin 797 ADP 793 ADP 792 glucose 783 acetate 691 cGMP 678 DNA 592 phosphate 584 Mg2+ 470 noradrenaline 461 adenylate 452 water 393 PGE2 391 TSH 364 prostacyclin 359 GDP 358 potassium 355 ACTH 350 Isoproterenol 332 arginine 312 manganese 300 Adenosine 291 5-HT 291 nitric oxide 280 tyrosine 249 GMP 242 Dopamine 218 NAD 211 glutamate 204 sulfate 196 ethanol 185 oxygen 173 PGE 171 Adrenal 165 lysine 157 leucine 154 Glucagon 152 NAD 152 Phe 147 NH2 145 His 140 iodine 135 alanine 132 glycerol 130 Insulin 127 caffeine 126 serine 125 salt 121 methionine 119 GABA 118 GABA 118 ICI 118 Norepinephrine 116 Histamine 114 PMA 106 galactose 106 Cardiol 105 PMA 105 SDS 103 aldosterone 102 ACh 102 TPA 96 TPA 96 threonine 90 urea 88 COS 87 EDTA 85 EDTA 85 Gly 84 PGD2 83 Theophylline 80 Thyroid 78 cysteine 77 GM1 77 Carbachol 75 vitamin D 74 Propranolol 73 Propranolol 72 carbonate 70 MgCl2 70 TRH 69 hydrogen 69 Guanine 67 bromide 67 Triton X-100 67 Calcitonin 66 nitrogen 65 Ile 64 HCl 63 PEG 62 retinoic acid 62 PAC 62 Lithium 60 DHA 59 PNP 59 DHA 58 DHA 58 fluorine 57 ammonium 57 UTP 57 gamma-aminobutyric acid 56 isoleucine 54 DEAE 53 Asp 53 nicotinic acid 52 isoleucine 52 Angiotensin II 52 CO2 52 cobalt 51 Vasopressin 51 nicotinic acid 50 Phorbol 50 nicotinamide 49 tryptophan 49 nicotinic acid 48 nicotinic acid 48 zinc 47 CPT 46 Prostaglandin 45 cyclopentyl 45 Prostaglandin 45 Indomethacin 45 ADP-ribose 45 MEK 45 tryptophan 43 tryptophan 43 tryptophan 43 Secretin 43 Morphine 42 Pac 41 glutamine 41 CPT 41 Dibutyryl cyclic AMP 41 alpha-MSH 41 Dibutyryl cyclic AMP 41 Tris 40 alloxan 40 cadmium 39 phosphorus 38 Dexamethasone 38 PEG 37 Sodium 37 TNF 37 Progesterone 37 Melatonin 36 CTP 36 H2O2 36 Thrombin 35 dipropyl 35 Guo 35 more...

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