Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Incubation at 41 degrees C stops the proliferation of tsK-NRK rat kidney cells in serum-deficient medium by inactivating the mitogenic/oncogenic thermolabile viral
K-RAS protein
that is produced in these cells. Dropping the temperature to 36 degrees C reactivates the viral
K-RAS protein
which stimulates the serum-starved quiescent cells to resume proliferating without added serum factors. Here it is shown that while the reactivated viral protein does not by itself significantly stimulate
adenylate cyclase
, it greatly increases the stimulability of
adenylate cyclase
by cholera toxin. The data suggest that the viral
K-RAS protein
directly or indirectly affects
adenylate cyclase
by inactivating the Gi inhibitory component of the membrane associated enzyme.
...
PMID:A viral K-RAS protein increases the stimulability of adenylate cyclase by cholera toxin in NRK cells. 244 37
