Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TSH binds specifically to the TSH receptor present on the surface of thyroid follicular cells and consequently activates
adenylate cyclase
. It was not known, however, which of the two subunits of the TSH bound to the receptor. By covalently crosslinking TSH to its receptor and characterizing the product with antisera specific for either the alpha or beta subunit of TSH, we have shown that the
TSH beta subunit
but not the TSH alpha subunit crosslinks to the TSH receptor.
...
PMID:TSH crosslinks to the TSH receptor through the beta subunit. 298 74
