Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Iprindole
in vitro displaces mianserin from specific recognition sites (IC50 3 microM). Daily doses (5 mg/kg i.p.) of iprindole repeated for 3 weeks attenuate the norepinephrine stimulation of
adenylate cyclase
studied in brain slices. Whereas the attenuation of noradrenergic receptor function elicited by imipramine can be antagonized by lesions of serotonergic axons, the inhibition of norepinephrine-induced stimulation of
adenylate cyclase
elicited by iprindole or mianserin is not inhibited by serotonin axon lesions.
Iprindole
given daily repeatedly reduces the maximal number of binding sites of [3H]mianserin and [3H]ketanserin; both actions are unchanged by lesions of central serotonergic axons.
...
PMID:Comparison of iprindole, imipramine and mianserin action on brain serotonergic and beta adrenergic receptors. 632 70
