Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thyroid peroxidase
(
TPO
) located in the apical plasma membrane of follicular cells was investigated by means of a membrane-immunofluorescent technique. The epitope of
TPO
recognized by a murine monoclonal antibody (mAb 30.1.2) was identified on the apical membrane surface. Trypsinization removed
TPO
immunoreactivity and enzymatic activity after 60 min of incubation at 37 degrees C. The epitope reappeared on the apical membrane surface after short term culture for 120 min without the addition of TSH. With TSH the time required for reappearance was only 30 min.
TPO
activity was regenerated under both conditions. Since dibutyryl cyclic AMP could not accelerate the reappearance of the epitope, it was thought that
TPO
reappearance is mediated by other than the
adenylate cyclase
-cyclic AMP system.
...
PMID:Characterization of thyroid follicular cell apical plasma membrane peroxidase using monoclonal antibody. 244 44
