Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Connexin hemichannels play an important role in the control of cellular signaling and behaviors. Given that lowering extracellular Ca
2+
, a condition that activates hemichannels, is a well-characterized stimulator of
renin
in juxtaglomerular cells, we, therefore, tested a potential implication of hemichannels in the regulation of
renin
in As4.1
renin
-secreting cells. Lowering extracellular Ca
2+
induced hemichannel opening, which was associated with cAMP signaling pathway activation and increased
renin
production. Blockade of hemichannels with inhibitors or downregulation of Cxs with siRNAs abrogated the activation of cAMP pathway and the elevation of
renin
. Further analysis revealed that cAMP pathway activation was blocked by adenylyl cyclase inhibitor SQ 22536, suggesting an implication of
adenyl cyclase
. Furthermore, the participation of hemichannels in the activation of the cAMP signaling pathway was also observed in a renal tubular epithelial cell line NRK. Collectively, our results characterized the hemichannel opening as a presently unrecognized molecular event involved in low Ca
2+
-elicited activation of cAMP pathway and
renin
production. Our findings thus provide novel mechanistic insights into the low Ca
2+
-initiated cell responses. Given the importance of cAMP signaling pathway in the control of multiple cellular functions, our findings also highlight the importance of Cx-forming channels in various pathophysiological situations.
...
PMID:Connexin Hemichannels Contribute to the Activation of cAMP Signaling Pathway and Renin Production. 3258 70
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