Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.1 (adenylate cyclase)
 19,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of dynamic exercise on lymphocyte beta 2-adrenoreceptor density (BARD) and adenylate cyclase activity (ACA) basal and stimulated by isoproterenol (I). Gpp(NH)p, Gpp(NH)p+I, and forskolin (F), on plasma adrenaline and noradrenaline levels, renin activity (PRA) were compared in 6 healthy donors and 12 patients with essential hypertension (EH). Acute stimulation of sympathetic activity by dynamic exercise leads to a rapid increase in lymphocyte BARD in normotensive and hypertensive subjects. The rise in BARD was accompanied by a significant increase in lymphocyte basal ACA in normotensive subjects, but not hypertensive patients. In patients with EH, basal ACA changed after exercise according to their renin status: patients with low baseline PRA showed a decrease in basal ACA after exercise, whereas patients with normal baseline PRA showed an increase as did normotensive subjects. Patients with decreased basal ACA after exercise also showed a lower ACA stimulation by IPR, F, Gpp (NH)p and Gpp(NH)p+IPR, which did not change after exercise. These patients also exhibited substantial rises in PRA with exercise. These was an inverse relationship between exercise-induced changes in PRA and basal ACA. So the acute regulation of lymphocyte BARD-ACA system is changed in a subset of patients with EH. The pattern of the regulation of this lymphocyte system is associated that of baseline renin activity and of its response to exercise in patients with EH.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1989
PMID:[The effect of a submaximal physical load on the beta 2-adrenoreceptor-dependent adenylate cyclase system of the lymphocytes in hypertension]. 255 57

Beta 2-adrenergic receptor density and platelet adenylate cyclase activity were determined in the peripheral blood of healthy donors during short-term physical exercise and compared to changes in biochemical parameters. The data obtained indicate the activation of sympathetic-adrenal system in general and suggest phasic regulation of catecholamine beta-adrenergic receptors.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1987
PMID:[Effect of a physical load on the adrenergic receptor function of peripheral blood lymphocytes and thrombocytes in healthy donors]. 303 42

Calmodulin (CM) was found to activate adenylate cyclase (AC) in plasma membrane preparations of the rabbit heart in the presence of micromolar Ca2+ concentrations. CM action on the enzyme is terminated by trifluoperazine, troponin I and high Ma2 +/Ca2+ ratio. Isoproterenol in the presence of GTP, guanosine-5'-beta-gamma-imidotriphosphate[Cpp(NH)p] and sodium fluoride increases CM-dependent heart AC activity without changing the enzyme affinity to CM and Ca ions. CM has no effect on the convertion of regulatory N-protein into Gpp(NH)p-activated state. CM action on AC is revealed only if catalytic subunit forms a complex with regulatory N-protein. The conclusion was drawn that there is no distinct CM-dependent AC form in the heart, but the same catalytic subunit of the enzyme is regulated both by N-protein and CM. In the presence of Ca2+ and guanye nucleotides AC of the heart exists in the form of a complex: CM-catalytic subunit-N-protein.
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR 1984
PMID:[Calcium-dependent regulation of cardiac adenyl cyclase by calmodulin]. 632 45