Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.1 (adenylate cyclase)
 19,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Administration of estradiol to ovariectomized females did not affect either the rhythm and basic levels of activity of the enzyme regulating the formation of melatonin in the rat epiphysis-serotonin N-acetyltransferase or the activation of this enzyme by isoproterenol in vivo. Daily administration of estradiol to young rats from birth did not alter the rhythm or activity of serotonin N-acetyltransferase in the epiphysis as estimated on the 8th day of age. The ability of estradiol to suppress noradrenaline activation of adenyl cyclase in epiphysial homogenates and its inability to suppress the same activation of serotonin N-acetyltransferase suggests either that the activation of the latter enzyme by catecholamines could occur by other mechanisms than the adenyl cyclase system or that activation of adenyl cyclase by noradrenaline is not suppressed by estradiol to the same degree in vivo as in vitro.
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PMID:Effect of estradiol on the activity of serotonin N-acetyltransferase in the rat epiphysis. 107 81

We have demonstrated the net anabolic potential of a mid-region fragment of human parathyroid hormone (hPTH), and a protease resistant mutein derived from it, to stimulate growth of skeletal-derived tissues. The fragment hPTH (28-48), lacking the N-terminal amino acids necessary for stimulation of adenylate cyclase, and therefore unable to stimulate bone resorption by osteoclasts, was compared with the protease-resistant double-mutein hPTH (28-48) F34M L37T, full-length hPTH (1-84), the protease resistant form hPTH (1-84) L37T, 17beta estradiol (E(2)), and the combination of mid-region fragments of PTH and E(2). The hormones, at concentrations spanning a 100-fold range, were given by 14 injections (6/week, excluding Saturday), to 17-day-old female Wistar-derived rats. At the low concentration of 200 ng/day of PTH (1-84), or the molar equivalent of the fragment, and 50 ng E(2), all the hormones increased significantly the specific activity of creatine kinase (CK; a marker of skeletal cell proliferation) in tibial diaphysis and epiphysis, the width of the cortical bone in the humeral diaphysis, and the number of cells in the proliferating zone of the humeral epiphyseal growth plate. At a 10-fold lower concentration of both PTH and E(2), CK specific activity was synergistically stimulated in both diaphyseal bone and epiphyseal cartilage. However, PTH mid-region fragments at a dose of 1 microg/day did not increase trabecular bone volume.
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PMID:Selective anabolic effects of muteins of mid-region PTH fragments on skeletal tissues of prepubertal rats. 1179 68