Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.6.1.1 (adenylate cyclase)
 19,190 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Upon enzyme histochemical evaluation of palatine tonsils removed from 80 patients with chronic tonsillitis it was established that there is a close correlation between activity of prostaglandin synthetase (PG-synthetase), adenylate cyclase (AC), cellular cAMP, pattern of inflammation and the size of streptococcal foci. Enhanced enzymatic activity, elevated content of lymphoid and connective tissue cAMP are associated with minor interstitial streptococcal foci, being a frequent finding in mild inflammation. Low cellular cAMP in high PG-synthetase and AC activity occurs in mild inflammation and large-sized interstitial streptococcal foci. When both enzymatic activity and cellular cAMP are low, torpid inflammation indicates lack of tissue response to microbial invasion resulting in emergence of interstitial streptococcal colonies. In view of the essential role of mediator effects in the inflammation focus, high activity of tonsil PG-synthetase should be considered a major indicator of activated chronic tonsillitis.
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PMID:[Enzyme histochemical characteristics of prostaglandin synthetase, adenylate cyclase and cAMP in a focus of inflammation in chronic tonsillitis]. 284 91