Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.6.1.1 (
adenylate cyclase
)
19,190
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The beta-adrenergic receptor-coupled
adenylate cyclase
system has been investigated in normal and
Werner's syndrome
fibroblasts. The basal levels of cAMP in
Werner
and normal control cells were similar, whereas the isoproterenol-induced increase in cAMP levels was far less for
Werner
cells than for control cells. In the broken cell preparations isoproterenol stimulated the
adenylate cyclase
of only control cells, not of
Werner
cells, although NaF or prostaglandin E1 stimulated the enzyme of both cells to the same extent. The beta-adrenergic receptor concentrations analyzed with hydrophilic radioligand were nearly equal in
Werner
and in control cells. A reduction of functional activity of the beta-adrenergic receptor in
Werner
cells is thus suggested.
...
PMID:Reduced sensitivity to catecholamine in Werner's syndrome fibroblasts. 303 17
