Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.3.23 (GAS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The goal of this work was comparison of quality of life in chronic schizophrenic patients with that in healthy persons. As we had expected, the level of QoL in healthy persons was significantly higher than QoL in the examined patients. It also turned out that the level of everyday functioning in the group of healthy persons had certain impact on their subjective QoL. In the group of schizophrenic patients such relation was not detected. The patients' QoL was not influenced by their general level of functioning (measured on the GAS scale) or intensity of psychopathological symptoms either. The healthy persons examined by us expressed satisfaction with their emotional life, sense of freedom and responsibility, life in general and family relations significantly more often than the persons with schizophrenia. The patients admitted also that in everyday life they found it most difficult to exact their rights, make decisions, organize their daily schedule and ask for help.
Psychiatr Pol
PMID:[Subjective quality of life in patients with chronic schizophrenia and in healthy persons]. 973 82

Mental condition of 142 patents with a diagnosis of schizophrenia (according to ICD X:F 20) first admitted to Psychiatric Hospital at the age of 13-18 was assessed twice. The first assessment took place during their first hospitalization at Psychiatric Hospital, the second one--23 years later. PANSS, BPRS GAS Scale were used at the examination. Mean value of the exacerbation of symptoms and improvement rate were calculated for each group of symptoms: positive, negative and psychopathological. The interpretation of the links between selected factors and rates of improvement as well as the mean value of exacerbation of symptoms were obtained on PANSS Scale. The links between the life assessment index before the first hospitalization and a mean value of points on the PANSS Scale at the discharge from hospital and in the cathamnesis for positive and negative symptoms as well as i cathamnesis for psychopathological symptoms were proved. The obtained data confirm that after the first discharge from hospital more patients function better in life than after cathamnestic examination.
Psychiatr Pol
PMID:[Cathamnestic long-term study in early schizophrenia. The assessment of psychological status and social functioning]. 973 81

Costimulation between T cells and antigen-presenting cells is required for adaptive immune responses. CD40, a costimulatory molecule, is expressed in macrophages and microglia. The aberrant expression of CD40 is involved in human diseases including multiple sclerosis, rheumatoid arthritis, and Alzheimer's disease. CD40 expression is induced by a variety of stimuli, including IFN-gamma and lipopolysaccharide (LPS). In this study, we describe the molecular basis by which IFN-beta, a cytokine with immunomodulatory properties, regulates CD40 gene expression. IFN-beta induces CD40 expression in macrophages and microglia at the transcriptional level, and GAS elements in the CD40 promoter are required for IFN-beta-induced CD40 promoter activity. The critical role of signal transducers and activators of transcription-1alpha (STAT-1alpha) in this response was confirmed by utilizing primary microglia from STAT-1alpha deficient mice. IFN-beta induces suppressor of cytokine signaling-1 (SOCS-1) gene expression, which inhibits cytokine signaling by inhibiting activation of STAT proteins. The ectopic expression of SOCS-1 abrogates IFN-beta-mediated STAT-1alpha activation and inhibits IFN-beta-induced CD40 expression. IFN-beta-induced recruitment of STAT-1alpha and RNA Pol II and permissive histone modifications on the CD40 promoter are also inhibited by SOCS-1 overexpression. These novel results indicate that IFN-beta-induced SOCS-1 plays an important role in the negative regulation of IFN-beta-induced CD40 gene expression.
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PMID:IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia. 1657 71

Streptococcus pyogenes (group A Streptococcus, GAS) is a human pathogen that causes diseases of various intensity, from mild strep throat to life threatening invasive infections and postinfectional sequelae. S. pyogenes encodes multiple, often phage encoded, virulence factors and their presence is related to severity of the disease. Acquisition of mobile genetic elements, carrying virulence factors, as phages or ICEs (integrative and cojugative elements) has been shown previously to promote selection of virulent clones. We designed the system of eight low volume multi- and one singleplex PCR reactions to detect genes encoding twenty virulence factors (spd3, sdc, sdaB, sdaD, speB, spyCEP, scpA, mac, sic, speL, K, M, C, I, A, H, G, J, smeZ and ssa) and twenty one phage and ICE integration sites described so far for S. pyogenes. Classification of strains based on the phage and virulence factors absence or presence, correlates with PFGE MLST and emm typing results. We developed a novel, fast and cost effective system that can be used to detect GAS virulence factors. Moreover, this system may become an alternative and effective system to differentiate between GAS strains.
Pol J Microbiol 2011
PMID:A new rapid and cost-effective method for detection of phages, ICEs and virulence factors encoded by Streptococcus pyogenes. 2218 25