Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.2.3.23 (
GAS
)
957
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Plasmin
(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (
GAS
). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for
GAS
dissemination, however the contribution of tissue-type plasminogen activator (tPA) to
GAS
virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of
GAS
infection in the absence of tPA in AlbPLG1/tPA
-/-
mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of
GAS
infection, further highlighting the importance of its counterpart uPA in
GAS
disease.
...
PMID:Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. 3100 8
