Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.2.3.23 (GAS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The long-term outcome of 355 patients with affective, schizoaffective and schizophrenic disorders was evaluated after long duration of the illness (mean more than 25 years). All patients were personally interviewed using operational instruments (PSE, WHO/DAS, WHO/PIRS, GAS, Huber's Psychopathological Criteria). By application of descriptive methods, integrating operationally estimated findings with clinically-impressively estimated "interactional atmosphere", we defined eight types of phenomenological constellations of persistent alterations ("residual-types") of functional disorders: "depletion syndrome", "apathetic-paranoid syndrome (resp. apathetic-hallucinatory syndrome)", "adynamic-deficient syndrome", "chronic psychosis", "structural deformation", "asthenic insufficiency syndrome", "chronic subdepressive syndrome", and "chronic hyperthymic syndrome". It was found a different distribution of persistent alterations in affective and schizophrenic disorders while schizoaffective disorders occupied a position in-between. The differences in the phenomenology of persistent alterations are interpreted as the result of differing biological and psychological processes. It was also found that the phenomenology of persistent alterations is related to the degree of disability.
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PMID:[Phenomenologic constellations of persistent alterations in idiopathic psychoses. An empirical comparative study]. 177 Sep 67

Sixty-seven first episode schizophrenic patients (PSE-Catego criteria) have been included in this study in order to evaluate their prognosis and the factors predictive of their evolution. Potential predictive factors consisted of anamnestic and demographic data, scores on the Disability Assessment Schedule (DAS-WHO) and relatives' Expressed Emotion index (EE), measured by the Camberwell Family Interview (CFI). The outcome was assessed monthly by the Global Assessment Scale (GAS/DSM III-R). At four years, 39 patients (58%) were still being followed. 33% of the patients presented a good evolution (EGF > or = 51) and 67% of the patients a bad evolution (EGF < 51). Four factors predictive of the psychosocial adaptation were extracted using regression analysis: premorbid psychosocial evolution, EE, sex and psychiatric family history. These 4 factors predicted correctly 85% of cases. Moreover, the monthly follow-up of these patients pointed to three types of evolution: the patients presenting a good and stable evolution (22%), those presenting a bad and stable evolution (33%) and those presenting an oscillating evolution which fluctuated between good and bad periods (44%). However, no predictive factors of the psychosocial adaptation of these oscillating patients could be identified through the statistical analysis. These results take all their importance regarding the treatment of schizophrenic patients, for whom the therapeutic plans which have to be settled should take into account their prognosis in the most precise manner. Moreover, the predictive value of EE on psychosocial adaptation for a 4 years period is confirmed.
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PMID:[Four year follow-up of social adjustment of a cohort of schizophrenic patients]. 778 89