Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.3.23 (GAS)
 957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pleural empyema is a rare and serious complication of pneumonia. Although it is frequently seen in children, there are only a few reports about pleural empyema in newborn infants. Here we report a case of early onset neonatal pneumonia complicated with pleural empyema. The causal microorganism was group A beta-hemolytic streptococci (GAS or Streptococcus pyogenes) presumably originating from the mother, who had a puerperal infection. The mother had fever, pelvic pain, and abnormal vaginal discharge two days after delivery and subsequent increase in the antistreptolysin O titer, suggesting streptococcus infection. The patient was successfully treated by pleural drainage in addition to synergistic antimicrobial therapy.
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PMID:Pleural empyema due to group A beta-hemolytic streptococci in a newborn: case report. 2387 94

Streptococcal toxic shock syndrome (STSS) is a systemic, life-threatening illness usually caused by invasive respiratory tract or skin and soft tissue infections of Streptococcus pyogenes (group A streptococcus, GAS). We report the case of an adult woman with lactational amenorrhea and GAS vulvovaginitis progressing to STSS. She was admitted to our hospital because of fever, lethargy, and a 2-week history of vaginal discharge; she also had hypotension and multiple organ failure. Blood and urine cultures yielded gram-positive cocci and GAS. After 14 days of antimicrobial therapy, she fully recovered without any complications. The vulvovaginitis was most likely the portal of entry for GAS, which is rarely recognized as a causative pathogen of vulvovaginitis. Lactational amenorrhea is thought to be a risk factor for GAS vulvovaginitis. It is important for clinicians to recognize the possibility of GAS vulvovaginitis in breastfeeding women with vaginal symptoms and consider the necessity of prompt antibiotic treatment.
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PMID:Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 3115 10