Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.2.7 (heparinase)
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Human Gene/Protein
laminin alpha 5 chain 12.6
3-OST-4 12.3
3-OST-5 12.0
LC-PTP 11.9
3-OST-3 11.8
proline/arginine-rich end leucine-rich repeat protein 11.6
syndecan 2 11.4
chondroitinase 11.3
MUC-3 10.9
cPLA2-alpha 10.9
heparan sulfate proteoglycan core protein 10.7
HSPG 10.7
NDST2 10.6
HS3ST2 10.6
PTPsigma 10.4
Chondroitinase 10.4
Glypican-1 10.3
beta-1,3-galactosyltransferase 10.2
heparan sulfate proteoglycan 10.1
heparin binding protein 9.9
PAPP-A2 9.9
ZG16p 9.9
CS-3 9.8
sulfatase 2 9.7
PRELP 9.7
exostosin 9.4
plasminogen activator, urokinase 9.4
teneurin-1 9.3
N-syndecan 9.3
type XIX collagen 9.2
SLC35A3 9.2
epiglycanin 9.2
DMAT 9.2
G protein-linked receptor 9.1
osteoactivin 8.9
GRG 8.9
hyaluronidase 8.8
Lipoprotein lipase 8.8
syndecan 8.8
N-deacetylase/N-sulfotransferase 8.8
more...
Disease
DMAT 9.2
Osteopathia striata with cranial sclerosis 9.1
Teratocarcinoma 8.8
Myometrium 8.6
circulating anticoagulants 8.6
Epithelioma 8.5
diabetic ulcer 7.7
MPS IIIA 7.3
SHS 7.3
SHS 7.3
Aujeszky's disease 7.0
Hurler 6.8
Ross River 6.7
CSB 6.6
CSB 6.5
Sanfilippo 6.5
mastocytoma 6.4
PBD 6.2
urticaria pigmentosa 6.1
HEP 6.1
SMC 6.0
HDL3 5.9
tracheobronchitis 5.8
CSE 5.8
pasteurellosis 5.6
visual dysfunction 5.6
hypofibrinogenemia 5.6
Classical swine fever 5.5
hyperlipoproteinemia 5.5
laryngotracheitis 5.4
kidney tumor 5.4
Heparin-induced thrombocytopenia 5.4
PNS 5.3
MPS I 5.2
MPS II 5.2
Tic 5.2
Franklin 5.1
Human immunodeficiency virus type 5.1
Adhesion 5.1
systemic candidiasis 5.0
more...
Symptom
Stiffness 4.7
hypothermia 2.5
hyperoxia 2.3
flushing 2.0
hypercapnia 1.7
acidity 0.7
analgesia -0.2
collapse -0.2
diarrhea -1.2
seizures -1.7
anesthesia -2.1
pain -3.4
Drug
Protamine sulfate 9.3
Lovenox 9.2
ABC 8.8
Dextran sulfate sodium 8.6
Orgaran 8.4
Pronase 7.6
LMWH 7.6
Chlorate 7.4
FLM 7.4
Hyaluronidase 7.4
Hyaluronidase 7.2
Antithrombin III 7.2
Dalteparin 7.1
APM 7.1
Argatroban 6.8
Cellulose acetate 6.6
Papain 6.5
IPD 6.4
Abciximab 6.4
Coumadin 6.2
RSM 6.2
Orlistat 6.0
ACT 5.9
Sinemet 5.5
Triad 5.3
MgSO4 5.0
Lovastatin 4.2
Meth 4.2
Gleevec 4.1
balanced salt solution 4.0
MRC 3.9
Fluorescein 3.7
NAG 3.5
Fragment 3.4
lysine 3.4
TAT 3.4
Gel 3.3
Imatinib 3.3
Fraction 3.3
Fluorescein 3.2
more...
Enzyme
heparinase 14.6
heparitinase I 13.1
D-glucuronyl C-5 epimerase 12.6
glycuronidase 12.1
chondroitinase B 11.7
chondroitinase AC 11.6
glucosaminyl 3-O-sulfotransferase 11.6
glucosaminyl 3-O-sulfotransferase 11.6
chondroitin ABC lyase 11.5
oligogalacturonate lyase 11.3
chondroitinase 11.2
chondroitinase 11.1
chondro-6-sulfatase 11.0
chondro-4-sulfatase 10.4
hyaluronidase 9.8
PATE 9.8
endo-beta-galactosidase 9.5
chondroitin 6-sulfotransferase 9.3
endo-beta-galactosidase 8.9
hyaluronidase 8.8
CPA2 8.8
benzoylformate decarboxylase 8.3
GPI-specific phospholipase C 8.2
phosphatidylinositol phospholipase C 8.0
hyaluronate lyase 7.9
endo-N 7.7
alginate lyase 7.6
bilirubin oxidase 7.6
UDP-glucose dehydrogenase 7.3
TSR 7.1
pregnancy-associated plasma protein-A 6.9
lysophospholipase D 6.8
thromboplastin 6.7
clostripain 6.7
lipoprotein lipase 6.6
C3b inactivator 6.6
neuraminidase 6.5
pectate lyase 6.4
PNL 6.2
ficin 6.2
more...
Compound
L-Cysteic acid 12.6
C16H14 12.3
Sodium chlorate 10.9
iduronate 10.7
CE 2 10.4
Azure A 10.1
Heparan sulfate 10.0
Polybrene 9.6
nitrous acid 9.3
hexuronic acid 9.2
hexuronic acid 9.1
hexuronic acid 9.1
hexuronic acid 9.1
Heparin 9.0
Chondroitin 8.8
TEG 8.8
D-glucuronic acid 8.5
keratan sulfate 8.5
GRG 8.2
Dermatan sulfate 8.1
Dermatan sulfate 8.1
Protamine 8.0
IBT 7.9
Chlorate 7.7
Ionophore A23187 7.5
Chondroitin sulfate 7.5
cysteate 7.5
Toluidine blue 7.4
SHS 7.4
Chlorate 7.3
D-glucosamine 7.2
benzo[ghi]perylene 7.2
sulfate 7.1
Suramin 6.8
Argatroban 6.8
Glucosamine 6.8
hyaluronic acid 6.8
sebacic acid 6.7
sebacic acid 6.7
Ruthenium red 6.6
more...