Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.2.7 (heparinase)
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Human Gene/Protein
laminin alpha 5 chain 12.6
3-OST-4 12.3
3-OST-5 12.0
LC-PTP 11.9
3-OST-3 11.8
proline/arginine-rich end leucine-rich repeat protein 11.6
syndecan 2 11.4
chondroitinase 11.3
cPLA2-alpha 10.9
MUC-3 10.9
heparan sulfate proteoglycan core protein 10.7
HSPG 10.7
NDST2 10.6
HS3ST2 10.6
PTPsigma 10.4
Chondroitinase 10.4
Glypican-1 10.3
beta-1,3-galactosyltransferase 10.2
heparan sulfate proteoglycan 10.1
heparin binding protein 9.9
PAPP-A2 9.9
ZG16p 9.9
CS-3 9.8
PRELP 9.7
sulfatase 2 9.7
exostosin 9.4
plasminogen activator, urokinase 9.4
teneurin-1 9.3
N-syndecan 9.3
type XIX collagen 9.2
SLC35A3 9.2
DMAT 9.2
epiglycanin 9.2
G protein-linked receptor 9.1
osteoactivin 8.9
GRG 8.9
hyaluronidase 8.8
Lipoprotein lipase 8.8
syndecan 8.8
N-deacetylase/N-sulfotransferase 8.8
heparanase 8.8
CPA2 8.8
nectin-1 8.8
ABC 8.8
lipoprotein receptor-related protein 8.7
HB-1 8.7
heparin cofactor II 8.7
heparin-binding protein 8.7
Hpa1 8.6
Antithrombin 8.6
2-O-sulfotransferase 8.6
Syndecan-2 8.5
Glypican-3 8.5
glypican 8.5
perlecan 8.5
Cholesterol esterase 8.5
proteoglycan core protein 8.4
Heparin cofactor II 8.4
cadherin protein 8.3
ankyrin G 8.3
ephrin-B3 8.3
Phospholipid transfer protein 8.3
high molecular weight mucin 8.3
IDUA 8.3
MUC3 8.2
DPP8 8.2
Histidine-rich glycoprotein 8.2
HVEM 8.2
Low density lipoprotein receptor 8.2
GMK 8.1
semenogelin 8.1
chondrocyte-derived 8.1
antithrombin III 8.0
Corin 8.0
T-synthase 8.0
WNT11 7.9
Zyxin 7.9
Platelet factor 4 7.8
caveolin 1 7.8
proteoglycan 7.8
keratan sulfate proteoglycan 7.8
Heparanase 7.7
aFGF 7.7
glucosamine 7.7
CPA1 7.7
UDP-glucose dehydrogenase 7.6
Tissue kallikrein 7.6
antithrombin 7.6
HB3 7.6
platelet factor 4 7.6
OST 7.6
HBM 7.6
MM46 7.6
Heparin-binding epidermal growth factor 7.6
ITF 7.6
corin 7.6
TBM 7.5
neuropilin 1 7.5
Heparan sulfate proteoglycan 7.5
VLDL receptor 7.4
A4 protein 7.4
SHS 7.4
IC2 7.4
Hyaluronidase 7.4
Connective tissue growth factor 7.3
p200 7.3
CS protein 7.3
Low-density lipoprotein receptor 7.3
ECGF 7.3
intercellular adhesion molecule-3 7.3
CD91 7.3
FGF receptor 7.3
GlcNAc transferase 7.2
trichohyalin 7.2
Neuraminidase 7.2
hES 7.2
laminin 5 7.2
heparin-binding epidermal growth factor 7.2
FGF18 7.2
SLL 7.2
hepatic lipase 7.2
peroxiredoxin 3 7.2
glucosaminyl 7.1
LRP1 7.1
Midkine 7.1
FGF-2 7.1
glycoprotein 2 7.1
EBS 7.1
sulfotransferase 7.0
heparin-binding EGF-like growth factor 7.0
LRP 7.0
PACE4 6.9
Caldesmon 6.9
MPS IIIA 6.9
core protein 6.9
TA3 6.9
endothelial lipase 6.9
phosphacan 6.8
IGFBP-5 6.8
MAV 6.8
GPIX 6.8
lipoprotein lipase 6.8
VLP 6.7
factor Xa 6.7
ADAMTS-4 6.7
eosinophil major basic protein 6.7
LDL receptor 6.7
alpha-L-fucosidase 6.7
tissue factor pathway inhibitor 6.7
Angiogenin 6.7
NIF 6.7
TCL 6.7
EXT 6.7
mucin 2 6.7
low density lipoprotein receptor 6.6
coagulation factor VII 6.6
ephrin-B1 6.6
neuraminidase 6.6
bFGF 6.6
Antithrombin III 6.6
more...
Disease
DMAT 9.2
Osteopathia striata with cranial sclerosis 9.1
Teratocarcinoma 8.8
Myometrium 8.6
circulating anticoagulants 8.6
Epithelioma 8.5
diabetic ulcer 7.7
MPS IIIA 7.3
SHS 7.3
SHS 7.3
Aujeszky's disease 7.0
Hurler 6.8
Ross River 6.7
CSB 6.6
CSB 6.5
Sanfilippo 6.5
mastocytoma 6.4
PBD 6.2
urticaria pigmentosa 6.1
HEP 6.1
SMC 6.0
HDL3 5.9
tracheobronchitis 5.8
CSE 5.8
pasteurellosis 5.6
visual dysfunction 5.6
hypofibrinogenemia 5.6
Classical swine fever 5.5
hyperlipoproteinemia 5.5
laryngotracheitis 5.4
kidney tumor 5.4
Heparin-induced thrombocytopenia 5.4
PNS 5.3
MPS I 5.2
MPS II 5.2
Tic 5.2
Franklin 5.1
Human immunodeficiency virus type 5.1
Adhesion 5.1
systemic candidiasis 5.0
nephrosis 5.0
rickettsiosis 5.0
CSA 4.9
acute monocytic leukemia 4.8
epithelioma 4.8
degenerative disc disease 4.7
transitional cell carcinoma of the bladder 4.7
venous stasis 4.6
Bartter's syndrome 4.6
AL amyloidosis 4.5
IVA 4.5
Thrombus 4.5
mastocytosis 4.5
HOS 4.5
coagulopathy 4.5
hemorrhagic fever 4.4
mucopolysaccharidosis 4.4
Dissociation 4.3
stomatitis 4.3
interstitial cystitis 4.3
spotted fever 4.2
myeloid leukemia 4.2
Hymenolepis 4.2
keratoconjunctivitis 4.2
coxsackievirus 4.2
achondroplasia 4.2
Rift Valley fever 4.1
nephrocalcinosis 4.1
EMD 4.1
fibrosarcoma 4.1
lysosomal storage disease 4.1
Blocking 4.0
SDS 4.0
anterior uveitis 4.0
hepatitis E 4.0
Japanese encephalitis 3.9
Dementia with Lewy bodies 3.9
endometrial adenocarcinoma 3.9
embryonal carcinoma 3.9
leptospirosis 3.8
AGA 3.8
disc degeneration 3.7
aseptic meningitis 3.7
atherosclerotic cardiovascular disease 3.7
Foot-and-mouth disease 3.6
EDA 3.6
RSV infection 3.6
MLC 3.6
Marek's disease 3.5
Wiskott-Aldrich syndrome 3.5
lupus nephritis 3.4
glomerulopathy 3.4
thrombophlebitis 3.4
primary sclerosing cholangitis 3.3
hypercalciuria 3.3
PAA 3.3
human papilloma virus 3.3
human papilloma virus 3.3
spongiform encephalopathy 3.3
epidermolysis bullosa 3.2
pituitary tumor 3.2
hepatoblastoma 3.2
idiopathic pulmonary fibrosis 3.2
arteriosclerosis 3.2
herpes simplex 3.2
atherosclerosis 3.1
disseminated intravascular coagulation 3.1
deep vein thrombosis 3.0
Adenovirus 3.0
tic 3.0
necrotizing enterocolitis 3.0
Chlamydia 3.0
hemolytic uremic syndrome 2.9
plaque 2.9
seminal vesicles 2.9
progressive supranuclear palsy 2.9
NS3 2.9
liposarcoma 2.8
macular degeneration 2.8
Plaque 2.8
Lyme disease 2.8
glioblastoma 2.8
dengue 2.7
scrapie 2.7
aqueous humor 2.6
erythroleukemia 2.6
mouth disease 2.6
mastitis 2.6
uterus 2.6
Still 2.5
chondrosarcoma 2.5
Kaposi's sarcoma 2.5
brain edema 2.5
glioblastoma multiforme 2.5
ABL 2.4
cytomegalovirus 2.4
primary biliary cirrhosis 2.4
antiphospholipid syndrome 2.4
chronic bronchitis 2.3
nephrotic syndrome 2.3
MIP 2.3
Alzheimer's disease 2.3
vaccinia 2.2
virus infection 2.2
zoonosis 2.2
Placenta 2.2
PSA 2.2
rhinitis 2.2
hepatitis C 2.2
intraocular pressure 2.1
aplastic anemia 2.1
proteinuria 2.1
thrombocytopenia 2.1
tumor angiogenesis 2.1
Burkitt's lymphoma 2.0
rhabdomyosarcoma 2.0
gonococcal 2.0
otitis media 1.9
nephritis 1.9
pancreatic cancer 1.9
more...
Symptom
Stiffness 4.7
hypothermia 2.5
hyperoxia 2.3
flushing 2.0
hypercapnia 1.7
acidity 0.7
analgesia -0.2
collapse -0.2
diarrhea -1.2
seizures -1.7
anesthesia -2.1
pain -3.4
Drug
Protamine sulfate 9.3
Lovenox 9.2
ABC 8.8
Dextran sulfate sodium 8.6
Orgaran 8.4
Pronase 7.6
LMWH 7.6
Chlorate 7.4
FLM 7.4
Hyaluronidase 7.4
Hyaluronidase 7.2
Antithrombin III 7.2
Dalteparin 7.1
APM 7.1
Argatroban 6.8
Cellulose acetate 6.6
Papain 6.5
IPD 6.4
Abciximab 6.4
Coumadin 6.2
RSM 6.2
Orlistat 6.0
ACT 5.9
Sinemet 5.5
Triad 5.3
MgSO4 5.0
Lovastatin 4.2
Meth 4.2
Gleevec 4.1
balanced salt solution 4.0
MRC 3.9
Fluorescein 3.7
NAG 3.5
Fragment 3.4
lysine 3.4
TAT 3.4
Gel 3.3
Imatinib 3.3
Fraction 3.3
Fluorescein 3.2
Alanine 3.2
Ringer's solution 3.1
CaCl2 3.0
CaCl2 3.0
CaCl2 2.9
HCH 2.9
FAD 2.2
Histamine 2.2
IFN-gamma 1.8
ROC 1.7
EE2 1.7
DNase I 1.6
Biopolymers 1.6
ENT 1.6
nitroglycerin 1.5
CTX 1.3
ascorbate 1.1
CSF 0.7
ROS 0.4
Leaf 0.2
IL-2 -0.2
Cardiovasc -0.7
Dermatol -1.4
Enzyme
heparinase 14.6
heparitinase I 13.1
D-glucuronyl C-5 epimerase 12.6
glycuronidase 12.1
chondroitinase B 11.7
chondroitinase AC 11.6
glucosaminyl 3-O-sulfotransferase 11.6
glucosaminyl 3-O-sulfotransferase 11.6
chondroitin ABC lyase 11.5
oligogalacturonate lyase 11.3
chondroitinase 11.2
chondroitinase 11.1
chondro-6-sulfatase 11.0
chondro-4-sulfatase 10.4
hyaluronidase 9.8
PATE 9.8
endo-beta-galactosidase 9.5
chondroitin 6-sulfotransferase 9.3
endo-beta-galactosidase 8.9
hyaluronidase 8.8
CPA2 8.8
benzoylformate decarboxylase 8.3
GPI-specific phospholipase C 8.2
phosphatidylinositol phospholipase C 8.0
hyaluronate lyase 7.9
endo-N 7.7
alginate lyase 7.6
bilirubin oxidase 7.6
UDP-glucose dehydrogenase 7.3
TSR 7.1
pregnancy-associated plasma protein-A 6.9
lysophospholipase D 6.8
thromboplastin 6.7
clostripain 6.7
lipoprotein lipase 6.6
C3b inactivator 6.6
neuraminidase 6.5
pectate lyase 6.4
PNL 6.2
ficin 6.2
PNGase F 6.0
dextranase 6.0
HCS 5.9
NAD glycohydrolase 5.9
DNase II 5.9
chymase 5.8
LPL 5.8
thrombin 5.7
deoxyribonuclease 5.7
deoxyribonuclease 5.6
Hageman factor 5.6
proprotein convertase 5.5
ADPase 5.5
PI-PLC 5.5
proteinase K 5.4
furin 5.3
sialidase 5.2
papain 5.1
sphingosine kinase 5.1
trypsin 5.0
sulfatase 5.0
plasmin 4.9
collagenase 4.8
cholesterol esterase 4.7
interstitial collagenase 4.7
angiotensin-converting enzyme 2 4.6
lysin 4.6
tissue plasminogen activator 4.3
DNase 4.3
urokinase-type plasminogen activator 4.2
neutrophil elastase 4.2
tryptase 4.2
MMP 4.1
histidine decarboxylase 4.1
MAT 4.1
pyruvate carboxylase 4.0
kallikrein 4.0
apyrase 4.0
dipeptidyl peptidase IV 3.9
phospholipase C 3.9
MAT 3.9
endoglycosidase H 3.8
lipase 3.8
HIV-1 protease 3.6
subtilisin 3.5
matrix metalloproteinase 2 3.4
phospholipase A2 3.4
TAT 3.4
alpha-amylase 3.3
myosin light chain kinase 3.2
histone acetyltransferase 3.2
protein phosphatase 2A 3.1
glucose-6-phosphatase 3.0
5'-nucleotidase 3.0
granzyme B 2.9
GSK 2.9
MMP-3 2.9
CD13 2.8
chymotrypsin 2.8
phosphatidylinositol 3-kinase 2.8
cathepsin D 2.6
xanthine oxidase 2.6
chitinase 2.6
beta-lactamase 2.5
protein kinase C 2.5
glutathione S-transferase 2.5
reverse transcriptase 2.5
elastase 2.5
transglutaminase 2.4
MIP 2.4
ceruloplasmin 2.3
hexokinase 2.2
APC 2.2
ERK 2.2
glyceraldehyde-3-phosphate dehydrogenase 2.2
dihydrofolate reductase 2.1
creatine kinase 2.0
choline acetyltransferase 2.0
ribonuclease 1.9
ribonuclease 1.9
cellulase 1.9
prostate-specific antigen 1.9
ATP synthase 1.8
lysozyme 1.8
urease 1.8
beta-galactosidase 1.8
urease 1.7
thymidine kinase 1.7
beta-glucuronidase 1.7
alkaline phosphatase 1.7
guanylate cyclase 1.6
DNA polymerase 1.6
pepsin 1.5
lipoxygenase 1.5
mitogen-activated protein kinase 1.5
focal adhesion kinase 1.5
RNase 1.5
gamma-glutamyl transpeptidase 1.5
endonuclease 1.4
transcriptase 1.4
peroxidase 1.2
protein kinase 1.1
cholinesterase 1.0
luciferase 1.0
acid phosphatase 1.0
acetylcholinesterase 0.8
NO synthase 0.7
RNase 0.6
RNA polymerase 0.5
MEK 0.5
catalase 0.4
phosphodiesterase 0.4
superoxide dismutase 0.4
ACS 0.4
ATPase 0.2
Compound
L-Cysteic acid 12.6
C16H14 12.3
Sodium chlorate 10.9
iduronate 10.7
CE 2 10.4
Azure A 10.1
Heparan sulfate 10.0
Polybrene 9.6
nitrous acid 9.3
hexuronic acid 9.2
hexuronic acid 9.1
hexuronic acid 9.1
hexuronic acid 9.1
Heparin 9.0
Chondroitin 8.8
TEG 8.8
D-glucuronic acid 8.5
keratan sulfate 8.5
GRG 8.2
Dermatan sulfate 8.1
Dermatan sulfate 8.1
Protamine 8.0
IBT 7.9
Chlorate 7.7
Ionophore A23187 7.5
Chondroitin sulfate 7.5
cysteate 7.5
Toluidine blue 7.4
SHS 7.4
Chlorate 7.3
D-glucosamine 7.2
benzo[ghi]perylene 7.2
sulfate 7.1
Suramin 6.8
Argatroban 6.8
Glucosamine 6.8
hyaluronic acid 6.8
sebacic acid 6.7
sebacic acid 6.7
Ruthenium red 6.6
sebacic acid 6.6
IPD 6.4
DDA 6.3
DDA 6.3
DDA 6.3
PBD 6.2
HEP 6.1
Ruthenium 6.1
Ruthenium 6.1
Plasmin 6.0
GlcNAc 5.9
Selectin 5.8
DEAE 5.7
Nitrite 5.7
Nitro-L-arginine 5.7
GalNAc 5.6
CAA 5.6
Organon 5.4
Factor H 5.4
Isoform 5.4
Cytochalasin D 5.4
Phorbol 12-myristate 13-acetate 5.2
hexanoic acid 5.1
APS 5.1
UGA 5.1
DAPT 5.1
Tunicamycin 5.1
Agarose 5.1
Polyamine 5.0
hexanoic acid 5.0
BaCl2 5.0
MIA 5.0
cyanamide 4.9
CPB 4.9
Pentobarbital 4.9
2-naphthyl 4.9
Thrombin 4.9
Thapsigargin 4.9
UDP-GlcNAc 4.8
Mannose 4.8
Purine 4.7
FDP 4.7
DTT 4.6
Collagenase 4.6
Eosin 4.6
guanidine 4.6
DTT 4.6
Phenylalanine 4.6
2-naphthol 4.5
2-naphthol 4.5
2-naphthol 4.5
HBr 4.5
Staurosporine 4.5
Wortmannin 4.5
ACI 4.4
Staurosporine 4.4
N-acetyl-D-glucosamine 4.4
Eosin 4.4
Dextran 4.4
hydroxylamine 4.2
PEA 4.2
hydroxylamine 4.2
Acetone 4.2
Pentobarbital 4.1
SO3 4.1
CPA 4.0
SDS 4.0
myristic acid 4.0
Guo 4.0
Trypsin 3.9
CPA 3.9
EDTA 3.9
Cysteine 3.9
EDTA 3.9
THP 3.9
CPA 3.9
THP 3.8
Choline 3.8
CBS 3.8
Triton X-100 3.7
PGD2 3.7
myristic acid 3.7
boric acid 3.7
SPM 3.7
CPA 3.6
2-mercaptoethanol 3.6
aminomethyl 3.6
sulfuric acid 3.6
Bradykinin 3.5
Guo 3.4
C-3 3.4
MgCl2 3.4
IAA 3.3
NTA 3.3
PAR 3.3
PAA 3.3
lysine 3.3
Hematoxylin 3.3
Warfarin 3.3
DIC 3.3
Alanine 3.2
Fibrinogen 3.2
BLM 3.2
IAA 3.2
sodium 3.1
octyl 3.1
octyl 3.1
Salt 3.1
octyl 3.1
hexose 3.1
TCA 3.1
Cellulose 3.1
arginine 3.1
PAS 3.0
COS 3.0
CaCl2 2.9
glutamic acid 2.9
Serine 2.9
HCl 2.9
Sucrose 2.8
more...