Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.2.2.7 (
heparinase
)
1,270
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The binding of [125I]-recombinant basic FGF (
rec
bFGF) to rat hepatic plasma membranes was investigated. [125I]
rec
bFGF bound to an apparent single class of high affinity binding sites (KD = 69 pM; Bmax = 9.61 fmoles/mg proteins). The absence of low affinity sites was confirmed by the inability of sulphated polysaccharides and
heparinase
to interfere with FGF binding. A good correlation existed between the ability of bovine pituitary-derived bFGF,
rec
bFGF and bovine brain-derived aFGF to displace [125I]
rec
bFGF from these binding sites and their in vitro potency on bovine aortic endothelial cell proliferation.
...
PMID:High affinity binding sites for basic fibroblast growth factor in rat hepatic plasma membranes. 256 19
