Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.1.22 (cystathionine beta-synthase)
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Human Gene/Protein
cystathionine beta-synthase 673
cystathionine gamma-lyase 85
Mol 80
methylenetetrahydrofolate reductase 58
Sep 57
methionine synthase 46
CBS 45
reductase 42
GSH 30
B12 27
Cystathionine gamma-lyase 24
ATP 23
SAM 20
superoxide dismutase 19
CBS protein 19
polypeptide 17
insulin 17
methyltransferase 16
methionine synthase reductase 15
5,10-methylenetetrahydrofolate reductase 12
PLP 12
MTHFR 12
AMP 12
dimeric 11
TOF 11
casein 11
glutathione reductase 10
MTRR 10
rohu 10
glutathione S-transferase 9
chromosome 21 9
catalase 9
SOD 9
Glycine N-methyltransferase 9
calmodulin 8
AMP-activated protein kinase 8
protein C 7
heme oxygenase-1 7
endoplasmic reticulum 7
GCS 7
Gen 7
nitric oxide synthase 7
BHMT 6
factor V Leiden 6
glutathione peroxidase 6
Sp1 6
Pseudomonas 6
malate dehydrogenase 6
reduced folate carrier 6
MAT1A 6
MTR 6
unknown function 6
betaine-homocysteine methyltransferase 6
Pol 5
ATP synthase 5
S-adenosylhomocysteine hydrolase 5
tRNA 5
fibrinogen 5
GST 5
proteasome 5
fused 5
ATPase 5
threonine 5
enolase 5
glutathione peroxidase 1 5
sulfotransferase 5
albumin 5
C-terminal peptide 5
APS kinase 5
matrix metalloproteinase 4
cys 4
thrombin 4
antioxidant enzyme 4
ESI 4
lactate dehydrogenase 4
paraoxonase 4
Bot 4
Met 4
cysteine desulfhydrase 4
metallothionein 4
more...
Disease
homocystinuria 167
hyperhomocysteinemia 108
CBS deficiency 60
vascular disease 43
atherosclerosis 37
cardiovascular disease 35
GSH 30
mental retardation 28
mental retardation 27
stroke 24
diabetes 19
Down syndrome 19
Alzheimer's disease 19
hypertension 17
folate deficiency 16
coronary artery disease 14
cancer 14
Mycobacterium 13
malnutrition 13
hypermethioninemia 12
arteriosclerosis 11
fatty liver 10
genetic disorder 10
ischemia 9
osteoporosis 9
hepatocellular carcinoma 8
tumor 8
tuberculosis 8
myocardial infarction 8
chronic myeloid leukemia 6
prostate cancer 5
Bateman 5
amebiasis 5
cognitive impairment 5
deep vein thrombosis 4
obesity 4
chronic renal failure 4
myocardial ischemia 4
Brucella abortus 4
hypercholesterolemia 4
cystathioninuria 4
epilepsy 4
Marfan syndrome 4
Huntington's disease 4
coronary heart disease 4
peripheral vascular disease 4
renal disease 4
myopia 4
depression 3
CSE 3
liver disease 3
pheochromocytoma 3
NAME 3
vitamin B6 deficiency 3
carcinogenesis 3
metabolic disorder 3
cerebral ischemia 3
preeclampsia 3
psychosis 3
hyperlipidemia 3
leishmaniasis 3
pulmonary embolism 3
dementia 3
pulmonary hypertension 3
SDS 3
type 2 diabetes 3
glomerulosclerosis 2
Wolff-Parkinson-White syndrome 2
brucellosis 2
hemiparesis 2
heart failure 2
alcoholic fatty liver 2
phenylketonuria 2
TAM 2
ALD 2
APC 2
venous disease 2
cerebral infarction 2
hyperinsulinemia 2
ICP 2
more...
Symptom
starvation 11
seizures 6
dystonia 3
ataxia 3
pain 2
hyperoxia 1
HSA 1
exhaustion 1
hepatomegaly 1
Involuntary Movement 1
diarrhea 1
hypothermia 1
iridodonesis 1
tremor 1
fatigue 1
collapse 1
Drug
pyridoxal phosphate 54
THF 19
lysine 11
Vitamin B 9
Glutathione 7
ascorbate 3
Heme 3
Ethanol 3
O-Acetylserine 3
DNase I 2
L-Ser 2
ROS 2
NADH 2
vitamin E 2
Capsicum 2
Pyridoxal 1
RbCl 1
Nephron 1
G-CSF 1
Sodium nitroprusside 1
NH3 1
Antithrombin III 1
Nitric Oxide 1
MRC 1
Pyridoxal phosphate 1
Vitamin K 1
Gly-Tyr-Gly 1
Alanine 1
ABC 1
Nephron 1
Dermatol 1
Glycyrrhiza 1
Glucagon 1
ACT 1
Vitamin B12 1
RbCl 1
Digitalis 1
ALA 1
Cardiovasc 1
GEO 1
niacin 1
Trifluoromethionine 1
balanced salt solution 1
Enzyme
cystathionine beta-synthase 965
cysteine synthase 269
cystathionine gamma-lyase 108
methylenetetrahydrofolate reductase 63
methylenetetrahydrofolate reductase 63
serine acetyltransferase 54
methionine synthase 46
methionine synthase 46
methionine adenosyltransferase 26
tryptophan synthase 22
superoxide dismutase 22
L-serine dehydratase 17
L-serine hydro-lyase 16
glutathione S-transferase 15
methionine synthase reductase 14
betaine-homocysteine methyltransferase 13
cystathionine gamma-synthase 13
ATP sulfurylase 13
homocysteine methyltransferase 13
cystathionine beta-lyase 12
APC 11
glutathione reductase 11
glycine N-methyltransferase 11
3-mercaptopyruvate sulfurtransferase 10
catalase 10
sulfite reductase 8
sulfite reductase 8
AMP-activated protein kinase 8
methioninase 7
protein kinase 7
sulfite reductase 7
malate dehydrogenase 7
CGT 7
lactate dehydrogenase 7
glutathione peroxidase 6
ascorbate peroxidase 6
serine hydroxymethyltransferase 6
beta-cyanoalanine synthase 6
mitogen-activated protein kinase 6
enolase 5
heme oxygenase 5
proteasome 5
ATP synthase 5
threonine deaminase 5
ATPase 5
NO synthase 5
glutathione synthetase 5
glyceraldehyde-3-phosphate dehydrogenase 5
phytochelatin synthase 5
peroxidase 5
methylenetetrahydrofolate dehydrogenase 4
methylenetetrahydrofolate dehydrogenase 4
NADPH oxidase 4
IMP dehydrogenase 4
paraoxonase 4
paraoxonase 4
NADPH oxidase 4
NQO1 4
pyruvate dehydrogenase 4
peroxiredoxin 4
ALA synthase 4
gamma-glutamylcysteine synthetase 4
aspartate aminotransferase 4
thrombin 4
nitrate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
nitrate reductase 3
ERK 3
aconitase 3
nitrate reductase 3
nitrate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
glyceraldehyde-3-phosphate dehydrogenase 3
isocitrate dehydrogenase 3
nitrate reductase 3
cyclohydrolase 3
glutamate synthase 3
isocitrate dehydrogenase 3
reverse transcriptase 3
pyruvate dehydrogenase 3
more...
Compound
homocysteine 382
cysteine 314
methionine 236
serine 143
adenosylmethionine 98
H2S 96
phosphate 81
Dec 78
O-acetylserine 73
DNA 63
H2S 58
O-acetylserine 53
O-acetylserine 52
oxygen 45
CBS 45
S-adenosylhomocysteine 43
sulfate 42
Cysteine 42
Homocysteine 41
Homocysteine 41
betaine 40
nitric oxide 34
GSH 34
GSH 34
Clin 31
hydrogen 26
ATP 24
sodium 23
water 21
nitrogen 20
His 20
CO2 18
iron 18
arginine 18
lysine 17
alanine 16
Cystathionine 15
salt 15
Cystathionine 14
calcium 14
glucose 14
Methionine 14
PLP 13
ethanol 12
AMP 12
cyanide 12
tryptophan 11
glutamate 11
TOF 11
tryptophan 11
tyrosine 10
zinc 10
ammonia 9
tryptophan 9
copper 9
tryptophan 9
urea 9
homoserine 7
selenium 7
homoserine 7
glutamine 7
potassium 7
proline 7
PGA 7
hydroxylamine 7
Serine 7
homoserine 7
acetyl-CoA 7
cadmium 7
hydroxylamine 7
Pyridoxine 6
2-mercaptoethanol 6
Gly 6
APS 6
phosphoserine 6
PEG 5
creatinine 5
methanethiol 5
GSSG 5
H2O2 5
more...