Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.1.22 (cystathionine beta-synthase)
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Human Gene/Protein
cystathionine beta-synthase 673
cystathionine gamma-lyase 85
Mol 80
methylenetetrahydrofolate reductase 58
Sep 57
methionine synthase 46
CBS 45
reductase 42
GSH 30
B12 27
Cystathionine gamma-lyase 24
ATP 23
SAM 20
superoxide dismutase 19
CBS protein 19
insulin 17
polypeptide 17
methyltransferase 16
methionine synthase reductase 15
AMP 12
MTHFR 12
PLP 12
5,10-methylenetetrahydrofolate reductase 12
casein 11
TOF 11
dimeric 11
glutathione reductase 10
rohu 10
MTRR 10
glutathione S-transferase 9
chromosome 21 9
Glycine N-methyltransferase 9
SOD 9
catalase 9
calmodulin 8
AMP-activated protein kinase 8
heme oxygenase-1 7
protein C 7
nitric oxide synthase 7
endoplasmic reticulum 7
more...
Disease
homocystinuria 167
hyperhomocysteinemia 108
CBS deficiency 60
vascular disease 43
atherosclerosis 37
cardiovascular disease 35
GSH 30
mental retardation 28
mental retardation 27
stroke 24
diabetes 19
Alzheimer's disease 19
Down syndrome 19
hypertension 17
folate deficiency 16
cancer 14
coronary artery disease 14
malnutrition 13
Mycobacterium 13
hypermethioninemia 12
arteriosclerosis 11
fatty liver 10
genetic disorder 10
ischemia 9
osteoporosis 9
myocardial infarction 8
tumor 8
hepatocellular carcinoma 8
tuberculosis 8
chronic myeloid leukemia 6
cognitive impairment 5
amebiasis 5
Bateman 5
prostate cancer 5
cystathioninuria 4
myocardial ischemia 4
hypercholesterolemia 4
obesity 4
chronic renal failure 4
renal disease 4
more...
Symptom
starvation 11
seizures 6
dystonia 3
ataxia 3
pain 2
hyperoxia 1
HSA 1
exhaustion 1
hepatomegaly 1
Involuntary Movement 1
diarrhea 1
hypothermia 1
iridodonesis 1
tremor 1
fatigue 1
collapse 1
Drug
pyridoxal phosphate 54
THF 19
lysine 11
Vitamin B 9
Glutathione 7
Heme 3
ascorbate 3
Ethanol 3
O-Acetylserine 3
DNase I 2
L-Ser 2
ROS 2
NADH 2
vitamin E 2
Capsicum 2
Pyridoxal 1
RbCl 1
Nephron 1
G-CSF 1
Sodium nitroprusside 1
NH3 1
Antithrombin III 1
Nitric Oxide 1
MRC 1
Pyridoxal phosphate 1
Vitamin K 1
Gly-Tyr-Gly 1
Alanine 1
ABC 1
Nephron 1
Dermatol 1
Glycyrrhiza 1
Glucagon 1
ACT 1
Vitamin B12 1
RbCl 1
Digitalis 1
ALA 1
Cardiovasc 1
GEO 1
more...
Enzyme
cystathionine beta-synthase 965
cysteine synthase 269
cystathionine gamma-lyase 108
methylenetetrahydrofolate reductase 63
methylenetetrahydrofolate reductase 63
serine acetyltransferase 54
methionine synthase 46
methionine synthase 46
methionine adenosyltransferase 26
superoxide dismutase 22
tryptophan synthase 22
L-serine dehydratase 17
L-serine hydro-lyase 16
glutathione S-transferase 15
methionine synthase reductase 14
ATP sulfurylase 13
cystathionine gamma-synthase 13
homocysteine methyltransferase 13
betaine-homocysteine methyltransferase 13
cystathionine beta-lyase 12
glycine N-methyltransferase 11
glutathione reductase 11
APC 11
3-mercaptopyruvate sulfurtransferase 10
catalase 10
sulfite reductase 8
sulfite reductase 8
AMP-activated protein kinase 8
sulfite reductase 7
protein kinase 7
methioninase 7
malate dehydrogenase 7
CGT 7
lactate dehydrogenase 7
glutathione peroxidase 6
beta-cyanoalanine synthase 6
ascorbate peroxidase 6
serine hydroxymethyltransferase 6
mitogen-activated protein kinase 6
proteasome 5
more...
Compound
homocysteine 382
cysteine 314
methionine 236
serine 143
adenosylmethionine 98
H2S 96
phosphate 81
Dec 78
O-acetylserine 73
DNA 63
H2S 58
O-acetylserine 53
O-acetylserine 52
CBS 45
oxygen 45
S-adenosylhomocysteine 43
sulfate 42
Cysteine 42
Homocysteine 41
Homocysteine 41
betaine 40
GSH 34
GSH 34
nitric oxide 34
Clin 31
hydrogen 26
ATP 24
sodium 23
water 21
nitrogen 20
His 20
CO2 18
iron 18
arginine 18
lysine 17
alanine 16
salt 15
Cystathionine 15
glucose 14
calcium 14
more...