Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.1.22 (cystathionine beta-synthase)
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Human Gene/Protein
cystathionine beta-synthase 673
cystathionine gamma-lyase 85
Mol 80
methylenetetrahydrofolate reductase 58
Sep 57
methionine synthase 46
CBS 45
reductase 42
GSH 30
B12 27
Cystathionine gamma-lyase 24
ATP 23
SAM 20
CBS protein 19
superoxide dismutase 19
insulin 17
polypeptide 17
methyltransferase 16
methionine synthase reductase 15
5,10-methylenetetrahydrofolate reductase 12
more...
Disease
homocystinuria 167
hyperhomocysteinemia 108
CBS deficiency 60
vascular disease 43
atherosclerosis 37
cardiovascular disease 35
GSH 30
mental retardation 28
mental retardation 27
stroke 24
Alzheimer's disease 19
Down syndrome 19
diabetes 19
hypertension 17
folate deficiency 16
cancer 14
coronary artery disease 14
Mycobacterium 13
malnutrition 13
hypermethioninemia 12
more...
Symptom
starvation 11
seizures 6
dystonia 3
ataxia 3
pain 2
hyperoxia 1
HSA 1
exhaustion 1
hepatomegaly 1
Involuntary Movement 1
diarrhea 1
hypothermia 1
iridodonesis 1
tremor 1
fatigue 1
collapse 1
Drug
pyridoxal phosphate 54
THF 19
lysine 11
Vitamin B 9
Glutathione 7
ascorbate 3
Heme 3
O-Acetylserine 3
Ethanol 3
vitamin E 2
DNase I 2
ROS 2
NADH 2
L-Ser 2
Capsicum 2
ABC 1
Dermatol 1
RbCl 1
Glycyrrhiza 1
Sodium nitroprusside 1
more...
Enzyme
cystathionine beta-synthase 965
cysteine synthase 269
cystathionine gamma-lyase 108
methylenetetrahydrofolate reductase 63
methylenetetrahydrofolate reductase 63
serine acetyltransferase 54
methionine synthase 46
methionine synthase 46
methionine adenosyltransferase 26
tryptophan synthase 22
superoxide dismutase 22
L-serine dehydratase 17
L-serine hydro-lyase 16
glutathione S-transferase 15
methionine synthase reductase 14
homocysteine methyltransferase 13
cystathionine gamma-synthase 13
betaine-homocysteine methyltransferase 13
ATP sulfurylase 13
cystathionine beta-lyase 12
more...
Compound
homocysteine 382
cysteine 314
methionine 236
serine 143
adenosylmethionine 98
H2S 96
phosphate 81
Dec 78
O-acetylserine 73
DNA 63
H2S 58
O-acetylserine 53
O-acetylserine 52
oxygen 45
CBS 45
S-adenosylhomocysteine 43
Cysteine 42
sulfate 42
Homocysteine 41
Homocysteine 41
more...