Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:4.2.1.22 (cystathionine beta-synthase)
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Human Gene/Protein
phosphoinositide-3-kinase adaptor protein 1 15.0
cystathionine beta-synthase 15.0
G protein beta subunit-like protein 14.0
CBS protein 13.8
mitogen-activated protein kinase kinase kinase 9 13.4
alpha-A-crystallin 13.0
cystathionine gamma-lyase 13.0
NRBP2 12.7
nuclear receptor binding protein 2 12.7
Cystathionine gamma-lyase 12.7
KNP1 12.4
FTHFD 12.4
MPST 12.2
transposase-like protein 12.2
CYS1 12.1
TSKS 11.8
CLC2 11.6
CRYA1 11.6
pyridoxal phosphatase 11.4
EXOG 11.4
betaine homocysteine methyltransferase 11.3
5-methyltetrahydrofolate-homocysteine methyltransferase 11.1
Selenocysteine lyase 11.1
methionine synthase reductase 11.1
betaine-homocysteine methyltransferase 11.0
PRKAG1 10.9
BHMT2 10.9
CYP20 10.9
MAT1A 10.9
Reduced folate carrier 10.8
BHMT 10.8
cysteine desulfhydrase 10.7
methionine synthase 10.7
beta-alanine synthase 10.6
Glycine N-methyltransferase 10.6
CBS1 10.4
5,10-methylenetetrahydrofolate reductase 10.4
PIK3AP1 10.4
formyltetrahydrofolate dehydrogenase 10.4
Atg21 10.4
cblD 10.4
methionine adenosyltransferase II 10.3
MTHFD1 10.3
ribosomal protein S3a 10.2
Cysteine dioxygenase 10.1
ribosomal protein L30 10.1
APS kinase 10.0
MCM7 protein 10.0
PRKAA 10.0
mercaptopyruvate sulfurtransferase 9.9
methylenetetrahydrofolate reductase 9.9
p-hydroxyphenylpyruvate dioxygenase 9.8
CTH 9.8
putative oxidoreductase 9.8
myeloid zinc finger 1 9.8
NSR1 9.7
Methionine adenosyltransferase 9.7
rohu 9.7
MAP3K9 9.7
2'-phosphodiesterase 9.7
cblF 9.6
S-adenosylmethionine synthetase 9.5
histone-lysine N-methyltransferase 9.5
methylenetetrahydrofolate dehydrogenase 9.4
WIPI2 9.3
thiosulfate sulfurtransferase 9.3
ClC-1 9.3
serine/threonine kinase 11 9.3
GCAT 9.3
TCN2 9.2
MgtE 9.2
NUAK1 9.2
aconitate hydratase 9.1
MTRR 9.1
A transferase 9.0
LeuRS 9.0
Sgt1 9.0
ras-related protein 9.0
Pc2 9.0
SLC19A1 8.9
WRS 8.9
S-adenosylhomocysteine hydrolase 8.9
reduced folate carrier 8.9
phosphoserine aminotransferase 8.8
nuclear receptor co-repressor 8.8
MTR 8.8
phosphatidylethanolamine N-methyltransferase 8.8
choline dehydrogenase 8.8
S-adenosyl-L-homocysteine hydrolase 8.8
KS1 8.7
rotamase 8.7
acetyl-CoA carboxylase alpha 8.7
CBS 8.7
ADP/ATP translocase 8.7
GCSh 8.6
CLC-5 8.6
CDPX2 8.5
formyltetrahydrofolate synthetase 8.5
ribosomal protein L3 8.5
cysteine desulfurase 8.5
cysteinyl-tRNA synthetase 8.5
NifU 8.5
alcohol dehydrogenase 1 8.4
DRPLA 8.4
RanBPM 8.4
adenosyltransferase 8.4
cysteine dioxygenase 8.4
enhancer protein 8.4
2,4-dienoyl-CoA reductase 8.4
HIP1 8.3
cytochrome b561 8.3
PLP 8.3
polycomb group protein 8.2
Methylenetetrahydrofolate reductase 8.2
SAT2 8.1
L-lactate dehydrogenase 8.1
MTHFR 8.1
Serine hydroxymethyltransferase 8.1
ribosomal protein L7 8.0
RPS6KB1 8.0
MMACHC 8.0
cystathionine-beta-synthase 8.0
hnRNP H 8.0
GSH1 8.0
guanidinoacetate methyltransferase 8.0
PIAS3 7.9
ATP-binding cassette protein 7.9
soluble liver antigen 7.9
testis specific 7.9
Kruppel-like 7.8
IscS 7.8
UNG 7.8
MTF-1 7.8
propionyl-CoA carboxylase 7.8
serine hydroxymethyltransferase 7.7
AXIN1 7.7
SAT1 7.7
RFC1 7.7
ACACA 7.7
SAM 7.7
coproporphyrinogen oxidase 7.7
Paraoxonase 7.7
CLC 7.7
methylthioadenosine phosphorylase 7.7
ClC-5 7.6
Pyruvate carboxylase 7.6
glutathione synthetase 7.6
ribosomal protein S12 7.6
CLCN1 7.6
methionyl-tRNA synthetase 7.6
proton-coupled folate transporter 7.6
GSH synthetase 7.6
MNT 7.6
amidophosphoribosyltransferase 7.5
Nicotinamide N-methyltransferase 7.5
transaldolase 7.5
KA2 7.4
Paraoxonase 1 7.4
serine dehydratase 7.4
GCS 7.4
more...
Disease
CBS deficiency 14.3
homocystinuria 12.5
cystathioninemia 12.4
Carotid artery thrombosis 12.2
hypermethioninemia 11.7
cystathioninuria 11.2
methionine synthase deficiency 11.0
cblF 10.2
hyperhomocysteinemia 10.1
Bateman 9.1
vitamin B6 deficiency 8.8
disorders of amino acid metabolism 8.7
Activated protein C resistance 8.5
folate deficiency 8.3
brittle hair 8.2
X-linked sideroblastic anemia 8.1
SBMA 8.0
Demented 8.0
CSE 7.8
Dent's disease 7.8
nagana 7.4
Small intestine 7.3
Shigella boydii 7.1
AD1 7.1
memory disorder 6.8
LQT1 6.5
bubonic plague 6.4
vascular disease 6.4
amebiasis 6.3
venous disease 6.2
hypervitaminosis 6.0
arteriosclerosis 6.0
mental retardation 5.9
mental retardation 5.8
cystinosis 5.8
tyrosinemia 5.7
carotid disease 5.7
uvea 5.7
Dystonia 5.6
HEP 5.5
PCS 5.5
Down syndrome 5.5
lipidosis 5.5
RTS 5.4
Brucella abortus 5.4
AMN 5.3
acute intermittent porphyria 5.2
RDA 5.2
orf 5.2
genetic disorder 5.2
Marfan syndrome 5.2
mental handicap 5.1
Wolff-Parkinson-White syndrome 5.0
TAM 5.0
Phenylketonuria 5.0
mild mental retardation 5.0
Bartter's syndrome 5.0
peripheral vascular disease 5.0
organic disease 4.9
Thrombus 4.9
ALD 4.9
vitamin B12 deficiency 4.8
Krabbe disease 4.7
septal defect 4.7
GSH 4.7
Klinefelter's syndrome 4.7
Beckwith-Wiedemann syndrome 4.7
PIN 4.7
myopia 4.6
enzyme deficiency 4.6
fatty liver 4.6
DES 4.5
AIN 4.4
phenylketonuria 4.4
lymphosarcoma 4.3
metabolic disorder 4.3
coccidiosis 4.3
alcoholic fatty liver 4.2
sensory neuropathy 4.2
Endothelial dysfunction 4.1
cardiovascular disease 4.1
cardiovascular risk factor 4.1
NPC 4.0
atherosclerosis 4.0
chlorosis 3.9
malnutrition 3.9
Wiskott-Aldrich syndrome 3.9
PIN 3.8
Wilson's disease 3.7
renal ischemia 3.7
HSP 3.7
nephrolithiasis 3.6
renal artery stenosis 3.5
African trypanosomiasis 3.5
ACP 3.5
AAA 3.4
deep vein thrombosis 3.4
chronic myeloid leukemia 3.4
coronary artery disease 3.4
brucellosis 3.4
hypogonadotropic hypogonadism 3.3
Rett syndrome 3.3
hemiparesis 3.3
Huntington's disease 3.3
Nonalcoholic fatty liver 3.3
cerebral infarction 3.2
hypercholesterolemia 3.1
glomerulosclerosis 3.1
Mycobacterium 3.0
Giant 3.0
osteoporosis 2.9
abdominal aortic aneurysm 2.9
leishmaniasis 2.9
NAME 2.9
movement disorder 2.9
Prostate Cancer 2.9
transient ischemic attack 2.8
preeclampsia 2.8
pheochromocytoma 2.8
pulmonary embolism 2.7
ICP 2.7
APC 2.7
retinitis pigmentosa 2.7
gastric ulcer 2.7
acute pancreatitis 2.6
hyperlipidemia 2.6
cleft palate 2.6
hyperinsulinemia 2.6
male infertility 2.6
Placenta 2.6
chronic renal failure 2.5
cerebral ischemia 2.5
gastroenteritis 2.5
Alzheimer's disease 2.5
ARF 2.5
coronary heart disease 2.5
PCC 2.5
delirium 2.5
CTX 2.4
stroke 2.4
renal impairment 2.4
pulmonary hypertension 2.4
COPD 2.4
NOD 2.3
erectile dysfunction 2.2
Legionella 2.2
astrocytoma 2.2
iron deficiency 2.2
memory impairment 2.2
cognitive impairment 2.2
malabsorption 2.2
myocardial ischemia 2.1
obsessive-compulsive disorder 2.1
sleep apnea 2.0
irritable bowel syndrome 2.0
candidiasis 2.0
goiter 2.0
myocardial infarction 2.0
Cryptococcus neoformans 2.0
Chagas 2.0
more...
Symptom
iridodonesis 10.4
Involuntary Movement 6.3
starvation 3.9
dystonia 3.6
HSA 3.5
hyperoxia 2.7
ataxia 2.6
hepatomegaly 2.5
seizures 1.3
exhaustion 1.3
hypothermia 0.9
tremor 0.8
collapse 0.2
fatigue -0.6
diarrhea -0.8
pain -2.0
Drug
Trifluoromethionine 13.4
O-Acetylserine 11.1
Gly-Tyr-Gly 9.6
pyridoxal phosphate 9.5
L-Ser 8.2
Vitamin B 7.9
Pyridoxal phosphate 7.9
Pyridoxal 7.0
RbCl 6.9
RbCl 6.9
THF 6.3
Antithrombin III 6.0
Digitalis 5.8
Glutathione 5.4
Sodium nitroprusside 5.1
Heme 5.0
Capsicum 4.9
Vitamin B12 4.7
Vitamin K 4.6
Glycyrrhiza 4.5
balanced salt solution 4.4
GEO 4.4
ACT 3.9
Nitric Oxide 3.7
Alanine 3.6
ALA 3.6
Ethanol 3.3
MRC 3.3
Glucagon 3.1
niacin 3.1
DNase I 3.0
G-CSF 2.6
lysine 2.6
NH3 2.2
ascorbate 2.1
vitamin E 1.9
ABC 1.9
ROS 1.8
NADH 1.6
Nephron 1.5
Nephron 0.9
Cardiovasc -2.6
Dermatol -3.0
Enzyme
L-serine hydro-lyase 15.0
beta-pyrazolealanine synthase 15.0
cystathionine beta-synthase 15.0
ODAP synthase 15.0
EC 4.4.1.2 14.0
cysteine synthase 13.8
O-acetyl-L-serine acetate-lyase 13.7
quercetin 3-O-methyltransferase 13.4
EC 2.1.1.3 13.4
serine acetyltransferase 13.1
cystathionine gamma-lyase 12.7
beta-cyanoalanine synthase 12.6
Arabinose-5-phosphate isomerase 12.4
L-serine dehydratase 12.3
cysteine lyase 12.1
cystathionine beta-lyase 11.9
betaine-homocysteine methyltransferase 11.4
homocysteine methyltransferase 11.3
cystathionine gamma-synthase 11.2
homoglutathione synthetase 11.2
methionine synthase reductase 11.2
glycine N-methyltransferase 11.2
D-cysteine desulfhydrase 11.0
sucrose-phosphatase 10.8
methionine synthase 10.8
methionine synthase 10.7
ketopantoate hydroxymethyltransferase 10.7
methioninase 10.5
3-mercaptopyruvate sulfurtransferase 10.4
EC 2.3.1.29 10.3
DszB 10.3
methionine adenosyltransferase 10.3
methylenetetrahydrofolate dehydrogenase 10.3
8-amino-7-oxononanoate synthase 10.3
PLP phosphatase 10.3
ATP sulfurylase 10.2
tryptophan synthase 10.1
methylenetetrahydrofolate reductase 9.9
methylenetetrahydrofolate reductase 9.9
phytochelatin synthase 9.9
SsuD 9.8
methylenetetrahydrofolate dehydrogenase 9.8
sulfite reductase 9.7
caffeoyl-CoA O-methyltransferase 9.6
CobA 9.6
sulfite reductase 9.6
desulfinase 9.5
sulfite reductase 9.5
PAPS reductase 9.4
phospholipid methyltransferase 9.4
EC 1.7.7.1 9.4
APS kinase 9.2
DHAD 9.0
Delta6-desaturase 9.0
CGT 9.0
histone-lysine N-methyltransferase 9.0
10-formyltetrahydrofolate dehydrogenase 8.9
guanidinoacetate methyltransferase 8.9
threonine deaminase 8.8
leishmanolysin 8.8
phosphatidylethanolamine N-methyltransferase 8.8
threonine synthase 8.8
cinnamoyl-CoA reductase 8.8
D-serine dehydratase 8.8
CSAD 8.7
choline dehydrogenase 8.7
APS reductase 8.7
isoflavone reductase 8.7
cysteinyl-tRNA synthetase 8.6
glycerophosphodiester phosphodiesterase 8.6
tyrosine phenol-lyase 8.5
histidinol dehydrogenase 8.5
nicotinamide N-methyltransferase 8.5
serine hydroxymethyltransferase 8.4
PTR1 8.3
2,4-dienoyl-CoA reductase 8.3
cysteine dioxygenase 8.2
amidophosphoribosyltransferase 8.1
phosphoserine aminotransferase 8.0
alliinase 8.0
glutathione synthetase 7.9
S-adenosyl-L-homocysteine hydrolase 7.9
formyltetrahydrofolate synthetase 7.9
cyclohydrolase 7.8
IscS 7.8
dimethylarginine dimethylaminohydrolase 7.7
alanine racemase 7.7
phosphoglycerate dehydrogenase 7.7
enoyl-ACP reductase 7.6
propionyl-CoA carboxylase 7.6
enoyl-ACP reductase 7.6
propionyl-CoA carboxylase 7.6
tryptophanase 7.6
coproporphyrinogen III oxidase 7.5
methionyl-tRNA synthetase 7.4
transaldolase 7.4
acyl carrier protein synthase 7.3
choline oxidase 7.3
pyridoxal kinase 7.2
4-hydroxyphenylpyruvate dioxygenase 7.2
IMP dehydrogenase 7.2
methylthioadenosine phosphorylase 7.2
oxalate oxidase 7.1
acetate kinase 7.1
PRPP synthetase 7.1
pantothenate kinase 7.1
coproporphyrinogen oxidase 7.0
ALA synthase 7.0
lactic acid dehydrogenase 7.0
phosphoribulokinase 7.0
glutamate synthase 6.9
pyruvate oxidase 6.9
pyruvate oxidase 6.9
dissimilatory sulfite reductase 6.8
LuxS 6.8
leucyl-tRNA synthetase 6.8
porphobilinogen deaminase 6.7
orotate phosphoribosyltransferase 6.6
trypanothione reductase 6.5
reductoisomerase 6.5
gamma-glutamylcysteine synthetase 6.5
SOR 6.5
ACAT 6.5
fructokinase 6.5
rhodanese 6.5
lactate oxidase 6.5
nitrilase 6.4
ACC synthase 6.4
dUTPase 6.3
lysine decarboxylase 6.3
starch synthase 6.3
paraoxonase 6.3
tryptophan 2,3-dioxygenase 6.3
choline kinase 6.2
S-adenosylmethionine decarboxylase 6.2
sulfite oxidase 6.2
acetyl-CoA synthetase 6.2
lactic acid dehydrogenase 6.2
AMP-activated kinase 6.1
STK11 6.1
ascorbate peroxidase 6.1
sulfite oxidase 6.1
lactic acid dehydrogenase 6.1
asparagine synthetase 6.0
paraoxonase 6.0
dehydroascorbate reductase 5.9
ADP-glucose pyrophosphorylase 5.9
glycine decarboxylase 5.9
ornithine transcarbamylase 5.8
aconitase 5.8
lecithin:cholesterol acyltransferase 5.8
fumarate reductase 5.7
cellulose synthase 5.7
malate dehydrogenase 5.7
peroxiredoxin 5.6
rubisco 5.6
RNA ligase 5.6
enolase 5.5
glutamate synthase 5.4
glutamate synthase 5.4
more...
Compound
Homolanthionine 15.0
6,7-dimethoxyquinoxaline 14.0
2-vinylquinoline 14.0
C4H9NO3 12.7
O-acetylserine 12.6
O-acetylserine 12.5
C4H9NO3 12.4
O-acetylserine 12.4
Homocystine 12.2
A 186 11.1
Cystathionine 10.7
Cystathionine 10.7
2,2-dichloroacetamide 10.2
homocysteine 10.1
Homocysteine 10.0
Homocysteine 10.0
S-sulfocysteine 9.9
S-methylcysteine 9.9
Homocysteine thiolactone 9.4
CH3-THF 9.2
Pyridoxine 9.0
S-adenosylhomocysteine 9.0
gamma-Glutamylcysteine 8.9
Cysteine 8.7
3GC 8.7
CBS 8.6
mercaptopyruvate 8.6
H2S 8.6
propionyl-coenzyme A 8.6
adenosylmethionine 8.6
Guanidinoacetic acid 8.5
MMU 8.5
Copper sulfate 8.3
Arbutin 8.3
betaine 8.1
Phosphoserine 8.1
PLP 8.0
PYR 8.0
H2S 8.0
1,2-dichloroethylene 7.9
Methionine 7.9
methanethiol 7.8
1,2-dichloroethylene 7.8
pyrroline-5-carboxylate 7.7
MNT 7.5
DGE 7.4
DGE 7.4
DGE 7.4
ribose-5-phosphate 7.3
meso-diaminopimelate 7.2
Isoflavone 7.2
cysteine 7.1
2-oxobutyrate 7.1
Selenocysteine 7.1
methionine 7.0
Digitonin 7.0
Pyridoxal 7.0
SSH 6.9
Cyanidin 6.9
Chalcone 6.9
Hypericin 6.8
Glycine, 6.8
Na2S 6.8
2-oxobutyrate 6.8
Clotrimazole 6.6
APS 6.5
LIN 6.5
Glycine, 6.4
CNA 6.4
2-furaldehyde 6.3
Cystine 6.3
phosphoserine 6.3
homoserine 6.2
homoserine 6.2
homoserine 6.2
serine 6.2
Cys-Gly 6.1
Serine 6.1
Neutral Red 6.1
Coomassie Blue 6.1
D-Ala-D-Ala 6.0
Acyl-CoA 6.0
Creatine 6.0
ECS 5.8
PGA 5.6
Cystine 5.6
alpha-ketoisocaproate 5.6
2-mercaptoethanol 5.6
Dithiothreitol 5.6
delta-aminolevulinic acid 5.6
HEP 5.5
HgCl2 5.5
hydroxylamine 5.4
Sulforaphane 5.4
Menadione 5.4
acetyl-CoA 5.4
PAG 5.4
hydroxylamine 5.4
Dithiothreitol 5.4
SAH 5.4
AICAR 5.3
norleucine 5.3
tetraphosphate 5.2
dihydrofolate 5.1
Arsenic 5.1
Hypo 5.0
nicotinic acid 4.9
norleucine 4.9
Emodin 4.9
MTA 4.9
GSSG 4.9
1,4-dioxane 4.8
Heme 4.8
Coenzyme Q10 4.8
1H-pyrazole 4.8
Baclofen 4.8
GSH 4.8
GSH 4.7
cyanide 4.6
tellurium 4.5
DES 4.5
SO3 4.5
AICAR 4.5
nicotinic acid 4.5
nicotinic acid 4.5
L-threonine 4.4
PIN 4.4
nicotinic acid 4.4
1H-indole 4.4
tert-butyl hydroperoxide 4.3
SOA 4.3
folinic acid 4.3
ubiquinol 4.3
Flux 4.3
Choline 4.2
TOF 4.1
Pyruvate 4.1
CMP 4.1
PPi 4.0
CMP 4.0
neopterin 4.0
PHB 4.0
TXA2 4.0
pentose 3.9
phosphate 3.9
ethylbenzene 3.9
ornithine 3.9
ornithine 3.9
ornithine 3.9
ornithine 3.9
ornithine 3.9
ATA 3.8
ASC 3.8
coenzyme Q10 3.8
Cycloheximide 3.8
Ethylene 3.8
2-oxoglutarate 3.7
chalcone 3.7
Amphotericin B 3.7
Alanine 3.6
more...