Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:4.2.1.22 (cystathionine beta-synthase)
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Human Gene/Protein
cystathionine beta-synthase 673
cystathionine gamma-lyase 85
Mol 80
methylenetetrahydrofolate reductase 58
Sep 57
methionine synthase 46
CBS 45
reductase 42
GSH 30
B12 27
Cystathionine gamma-lyase 24
ATP 23
SAM 20
CBS protein 19
superoxide dismutase 19
polypeptide 17
insulin 17
methyltransferase 16
methionine synthase reductase 15
5,10-methylenetetrahydrofolate reductase 12
AMP 12
MTHFR 12
PLP 12
TOF 11
casein 11
dimeric 11
MTRR 10
glutathione reductase 10
rohu 10
chromosome 21 9
Glycine N-methyltransferase 9
catalase 9
SOD 9
glutathione S-transferase 9
AMP-activated protein kinase 8
calmodulin 8
endoplasmic reticulum 7
GCS 7
nitric oxide synthase 7
protein C 7
Gen 7
heme oxygenase-1 7
reduced folate carrier 6
MTR 6
glutathione peroxidase 6
betaine-homocysteine methyltransferase 6
Pseudomonas 6
Sp1 6
malate dehydrogenase 6
BHMT 6
MAT1A 6
unknown function 6
factor V Leiden 6
ATPase 5
GST 5
glutathione peroxidase 1 5
proteasome 5
fused 5
C-terminal peptide 5
ATP synthase 5
fibrinogen 5
APS kinase 5
enolase 5
albumin 5
S-adenosylhomocysteine hydrolase 5
tRNA 5
threonine 5
sulfotransferase 5
Pol 5
ORF 4
Methionine adenosyltransferase 4
NMDA receptor 4
S-adenosylmethionine synthetase 4
glutathione synthetase 4
cytokine 4
metallothionein 4
matrix metalloproteinase 4
Met 4
paraoxonase 4
peroxidase 4
ADP 4
acetyltransferase 4
alternatively spliced 4
cys 4
apolipoprotein E 4
CBS1 4
CLC 4
antioxidant enzyme 4
Bot 4
thrombin 4
glucagon 4
ABC transporter 4
MTHFD1 4
methylenetetrahydrofolate dehydrogenase 4
aspartate aminotransferase 4
ESI 4
cysteine desulfhydrase 4
SAT 4
gut 4
NADPH 4
lactate dehydrogenase 4
prothrombin 4
membrane-bound 4
ribosomal protein 3
CTH 3
L-lactate dehydrogenase 3
membrane protein 3
HSP70 3
non-catalytic 3
serine hydroxymethyltransferase 3
erythroid 3
SDS 3
thymidylate synthase 3
factor V 3
porin 3
haptoglobin 3
CO2 3
transcriptional regulator 3
chronic renal failure 3
p38 3
GAPDH 3
peroxisome proliferator-activated receptor 3
MRI 3
ubiquitin 3
betaine homocysteine methyltransferase 3
Huntingtin 3
lipopolysaccharide 3
glyceraldehyde-3-phosphate dehydrogenase 3
thioredoxin 3
chloride channel 3
isocitrate dehydrogenase 3
p53 3
huntingtin 3
STZ 3
bradykinin 3
alpha, beta 3
UTR 3
lipoamide dehydrogenase 3
E.coli 3
ClC-1 3
ornithine transcarbamylase 3
cysteine desulfurase 3
pyruvate kinase 3
hemoglobin 3
pyruvate dehydrogenase 3
MPST 3
35 kDa 3
HDL 3
Methylenetetrahydrofolate reductase 3
PEG 3
ferritin 3
CHD 3
phosphatidylethanolamine N-methyltransferase 2
MMP-3 2
Nrf2 2
apoE 2
inorganic pyrophosphatase 2
ICP 2
cardiac muscle 2
aconitate hydratase 2
more...
Disease
homocystinuria 167
hyperhomocysteinemia 108
CBS deficiency 60
vascular disease 43
atherosclerosis 37
cardiovascular disease 35
GSH 30
mental retardation 28
mental retardation 27
stroke 24
Alzheimer's disease 19
Down syndrome 19
diabetes 19
hypertension 17
folate deficiency 16
cancer 14
coronary artery disease 14
Mycobacterium 13
malnutrition 13
hypermethioninemia 12
arteriosclerosis 11
fatty liver 10
genetic disorder 10
ischemia 9
osteoporosis 9
hepatocellular carcinoma 8
tumor 8
myocardial infarction 8
tuberculosis 8
chronic myeloid leukemia 6
prostate cancer 5
amebiasis 5
cognitive impairment 5
Bateman 5
myopia 4
Huntington's disease 4
renal disease 4
chronic renal failure 4
hypercholesterolemia 4
peripheral vascular disease 4
myocardial ischemia 4
cystathioninuria 4
obesity 4
epilepsy 4
Marfan syndrome 4
coronary heart disease 4
deep vein thrombosis 4
Brucella abortus 4
pulmonary embolism 3
vitamin B6 deficiency 3
type 2 diabetes 3
preeclampsia 3
cerebral ischemia 3
depression 3
CSE 3
carcinogenesis 3
hyperlipidemia 3
pheochromocytoma 3
liver disease 3
metabolic disorder 3
leishmaniasis 3
psychosis 3
dementia 3
pulmonary hypertension 3
NAME 3
SDS 3
Thrombus 2
abdominal aortic aneurysm 2
APC 2
alcoholic fatty liver 2
hyperinsulinemia 2
brucellosis 2
ICP 2
gastroenteritis 2
acute myocardial infarction 2
carcinoma 2
cerebral infarction 2
chronic obstructive pulmonary disease 2
mole 2
renal failure 2
colon cancer 2
cold 2
mole 2
phenylketonuria 2
tumor growth 2
hepatitis 2
venous disease 2
cleft palate 2
inflammatory bowel disease 2
tumorigenesis 2
TAM 2
hemiparesis 2
glomerulosclerosis 2
Wolff-Parkinson-White syndrome 2
ALD 2
acute pancreatitis 2
heart failure 2
suicide 2
disorders of amino acid metabolism 1
adenocarcinoma 1
cblF 1
essential hypertension 1
enzyme deficiency 1
goiter 1
renal ischemia 1
cardiovascular risk factor 1
irritable bowel syndrome 1
PIN 1
AD1 1
neuroblastoma 1
Demented 1
AAA 1
transient ischemic attack 1
Dystonia 1
cerebral palsy 1
X-linked sideroblastic anemia 1
ARF 1
mild mental retardation 1
virus infection 1
candidiasis 1
Prostate Cancer 1
organic disease 1
sepsis 1
bubonic plague 1
osteoarthritis 1
vitamin B12 deficiency 1
Parkinson's disease 1
hypothyroidism 1
methionine synthase deficiency 1
Placenta 1
adenoma 1
hyperglycemia 1
obsessive-compulsive disorder 1
sepsis 1
ovarian cancer 1
carotid disease 1
erectile dysfunction 1
PCS 1
mental handicap 1
tyrosinemia 1
lipidosis 1
African trypanosomiasis 1
aggression 1
malabsorption 1
SEM 1
nephrolithiasis 1
Bartter's syndrome 1
Beckwith-Wiedemann syndrome 1
neurological disease 1
Chagas 1
AIN 1
DBA 1
cystinosis 1
Krabbe disease 1
renal impairment 1
acute intermittent porphyria 1
plague 1
lung cancer 1
dehydration 1
Evans 1
more...
Symptom
starvation 11
seizures 6
dystonia 3
ataxia 3
pain 2
hyperoxia 1
HSA 1
exhaustion 1
hepatomegaly 1
Involuntary Movement 1
diarrhea 1
hypothermia 1
iridodonesis 1
tremor 1
fatigue 1
collapse 1
Drug
pyridoxal phosphate 54
THF 19
lysine 11
Vitamin B 9
Glutathione 7
ascorbate 3
Heme 3
Ethanol 3
O-Acetylserine 3
DNase I 2
L-Ser 2
ROS 2
NADH 2
vitamin E 2
Capsicum 2
Pyridoxal 1
RbCl 1
Nephron 1
G-CSF 1
Sodium nitroprusside 1
NH3 1
Antithrombin III 1
Nitric Oxide 1
MRC 1
Pyridoxal phosphate 1
Vitamin K 1
Gly-Tyr-Gly 1
Alanine 1
ABC 1
Nephron 1
Dermatol 1
Glycyrrhiza 1
Glucagon 1
ACT 1
Vitamin B12 1
RbCl 1
Digitalis 1
ALA 1
Cardiovasc 1
GEO 1
niacin 1
Trifluoromethionine 1
balanced salt solution 1
Enzyme
cystathionine beta-synthase 965
cysteine synthase 269
cystathionine gamma-lyase 108
methylenetetrahydrofolate reductase 63
methylenetetrahydrofolate reductase 63
serine acetyltransferase 54
methionine synthase 46
methionine synthase 46
methionine adenosyltransferase 26
superoxide dismutase 22
tryptophan synthase 22
L-serine dehydratase 17
L-serine hydro-lyase 16
glutathione S-transferase 15
methionine synthase reductase 14
betaine-homocysteine methyltransferase 13
cystathionine gamma-synthase 13
ATP sulfurylase 13
homocysteine methyltransferase 13
cystathionine beta-lyase 12
APC 11
glutathione reductase 11
glycine N-methyltransferase 11
3-mercaptopyruvate sulfurtransferase 10
catalase 10
AMP-activated protein kinase 8
sulfite reductase 8
sulfite reductase 8
sulfite reductase 7
lactate dehydrogenase 7
methioninase 7
protein kinase 7
CGT 7
malate dehydrogenase 7
ascorbate peroxidase 6
serine hydroxymethyltransferase 6
mitogen-activated protein kinase 6
beta-cyanoalanine synthase 6
glutathione peroxidase 6
enolase 5
glutathione synthetase 5
NO synthase 5
ATPase 5
phytochelatin synthase 5
heme oxygenase 5
glyceraldehyde-3-phosphate dehydrogenase 5
proteasome 5
ATP synthase 5
threonine deaminase 5
peroxidase 5
aspartate aminotransferase 4
paraoxonase 4
pyruvate dehydrogenase 4
paraoxonase 4
thrombin 4
gamma-glutamylcysteine synthetase 4
NQO1 4
NADPH oxidase 4
peroxiredoxin 4
IMP dehydrogenase 4
methylenetetrahydrofolate dehydrogenase 4
methylenetetrahydrofolate dehydrogenase 4
NADPH oxidase 4
ALA synthase 4
nitrate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
reverse transcriptase 3
glyceraldehyde-3-phosphate dehydrogenase 3
cyclohydrolase 3
glyceraldehyde-3-phosphate dehydrogenase 3
ERK 3
lactic acid dehydrogenase 3
nitrate reductase 3
diaphorase 3
nitrate reductase 3
nitrate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
isocitrate dehydrogenase 3
isocitrate dehydrogenase 3
nitrate reductase 3
pyruvate dehydrogenase 3
IscS 3
pyruvate kinase 3
nitrate reductase 3
ornithine transcarbamylase 3
aconitase 3
thymidylate synthase 3
ACS 3
luciferase 3
glutamate synthase 3
phosphatidylethanolamine N-methyltransferase 3
pyruvate dehydrogenase 3
glutamate dehydrogenase 2
alcohol dehydrogenase 2
CAD 2
methionyl-tRNA synthetase 2
S-adenosyl-L-homocysteine hydrolase 2
S-adenosylmethionine decarboxylase 2
choline oxidase 2
glutamate dehydrogenase 2
glutamate dehydrogenase 2
APS reductase 2
propionyl-CoA carboxylase 2
phospholipid methyltransferase 2
rubisco 2
phosphoenolpyruvate carboxykinase 2
phosphoglycerate dehydrogenase 2
phosphoenolpyruvate carboxykinase 2
citrate synthase 2
phosphoenolpyruvate carboxykinase 2
trypsin 2
glutamine synthetase 2
gamma-glutamyl transpeptidase 2
glutamate decarboxylase 2
tryptophan 2,3-dioxygenase 2
APS kinase 2
thioredoxin reductase 2
glucose-6-phosphate dehydrogenase 2
alanine aminotransferase 2
SOR 2
alanine racemase 2
tryptophanase 2
invertase 2
diaphorase 2
N-acetyltransferase 2
cysteine dioxygenase 2
acetate kinase 2
rhodanese 2
porphobilinogen deaminase 2
lecithin:cholesterol acyltransferase 2
transaldolase 2
O-acetyl-L-serine acetate-lyase 2
dimethylarginine dimethylaminohydrolase 2
beta-pyrazolealanine synthase 2
alkaline phosphatase 2
guanidinoacetate methyltransferase 2
dihydrofolate reductase 2
phosphoribulokinase 2
acetyl-CoA carboxylase 2
cysteine lyase 2
calcineurin 2
propionyl-CoA carboxylase 2
coproporphyrinogen III oxidase 1
acid phosphatase 1
orotate phosphoribosyltransferase 1
PRPP synthetase 1
amidophosphoribosyltransferase 1
DNA ligase 1
sucrose-phosphatase 1
DNA ligase 1
RNA ligase 1
arylsulfatase 1
acyl-CoA synthetase 1
prolyl endopeptidase 1
glutamate synthase 1
threonine synthase 1
adenosine kinase 1
choline kinase 1
fumarase 1
nitrilase 1
more...
Compound
homocysteine 382
cysteine 314
methionine 236
serine 143
adenosylmethionine 98
H2S 96
phosphate 81
Dec 78
O-acetylserine 73
DNA 63
H2S 58
O-acetylserine 53
O-acetylserine 52
oxygen 45
CBS 45
S-adenosylhomocysteine 43
Cysteine 42
sulfate 42
Homocysteine 41
Homocysteine 41
betaine 40
nitric oxide 34
GSH 34
GSH 34
Clin 31
hydrogen 26
ATP 24
sodium 23
water 21
His 20
nitrogen 20
iron 18
arginine 18
CO2 18
lysine 17
alanine 16
salt 15
Cystathionine 15
Cystathionine 14
calcium 14
glucose 14
Methionine 14
PLP 13
ethanol 12
AMP 12
cyanide 12
tryptophan 11
TOF 11
glutamate 11
tryptophan 11
tyrosine 10
zinc 10
tryptophan 9
copper 9
urea 9
ammonia 9
tryptophan 9
glutamine 7
proline 7
homoserine 7
PGA 7
Serine 7
homoserine 7
acetyl-CoA 7
cadmium 7
hydroxylamine 7
potassium 7
hydroxylamine 7
homoserine 7
selenium 7
APS 6
Pyridoxine 6
2-mercaptoethanol 6
Gly 6
phosphoserine 6
ammonium 5
PYR 5
NH2 5
creatinine 5
PEG 5
GSSG 5
Arsenic 5
methanethiol 5
threonine 5
H2O2 5
glycerol 4
NADPH 4
glutamic acid 4
NMDA 4
nicotinic acid 4
nitrate 4
silver 4
acetate 4
S-methylcysteine 4
LIN 4
NADPH 4
CoA 4
CH3-THF 4
ADP 4
leucine 4
ADP 4
ADP 4
cAMP 4
manganese 3
ornithine 3
aluminum 3
galactose 3
N-acetylcysteine 3
Asp 3
2-oxoglutarate 3
valine 3
S-sulfocysteine 3
PEG 3
NADP 3
pentose 3
ornithine 3
ornithine 3
ornithine 3
MDA 3
SDS 3
Heme 3
nicotinamide 3
ornithine 3
HgCl2 3
benzene 2
EDTA 2
nicotinic acid 2
mercury 2
3GC 2
molybdenum 2
methanol 2
ACS 2
EDTA 2
Insulin 2
sulfuric acid 2
asparagine 2
pyrroline-5-carboxylate 2
diacetate 2
Homocystine 2
xylose 2
ACS 2
pyridine 2
hydroxide 2
ribose-5-phosphate 2
toluene 2
nicotinic acid 2
carbonate 2
Creatine 2
cobalt 2
DEAE 2
butyric acid 2
nicotinic acid 2
alcohol dehydrogenase 2
delta-aminolevulinic acid 2
NADH 2
Ile 2
acrylamide 2
PAG 1
oxalic acid 1
oxalic acid 1
more...