Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.2.1.22 (
cystathionine beta-synthase
)
965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Copper was added to truncated, recombinant
cystathionine beta-synthase
(
CBS
), and the enzyme activity was assessed by measuring the production of cystathionine. 10 microM copper significantly decreased
CBS
activity by 50% while 25 microM copper decreased
CBS
activity by 70%. This inhibition was negated when an analog of the N-terminus of human albumin, Asp-Ala-His-Lys (DAHK), a strong transition metal
binding peptide
, was added. The use of copper chelators could significantly reduce in vivo homocysteine levels.
...
PMID:Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminus. 1577 77
