Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.2.1.22 (
cystathionine beta-synthase
)
965
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H
2
S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung
adenocarcinoma
tissue expresses high levels of hydrogen sulfide (H
2
S) producing enzymes, namely,
cystathionine beta-synthase
(
CBS
), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), in comparison to adjacent lung tissue. In cultured lung
adenocarcinoma
but not in normal lung epithelial cells elevated H
2
S stimulates mitochondrial DNA repair through sulfhydration of EXOG, which, in turn, promotes mitochondrial DNA repair complex assembly, thereby enhancing mitochondrial DNA repair capacity. In addition, inhibition of H
2
S-producing enzymes suppresses critical bioenergetics parameters in lung
adenocarcinoma
cells. Together, inhibition of H
2
S-producing enzymes sensitize lung
adenocarcinoma
cells to chemotherapeutic agents via induction of mitochondrial dysfunction as shown in in vitro and in vivo models, suggesting a novel mechanism to overcome tumor chemoresistance.
...
PMID:Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics. 2780 78
