Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:4.1.99.3 (
PRE
)
1,923
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
photolyase
13.9
Epitheliasin
13.0
epitheliasin
13.0
WDR87
13.0
photolyase-like
13.0
PHR1
11.7
POLR1B
11.2
ZK1
11.2
FBXL21
10.8
FADH2
10.8
Tpr1
10.7
FBXL3
10.6
CRY
10.3
cryptochrome 1
10.2
G-protein coupled receptor protein
10.2
CRY1
10.1
Helicase-like transcription factor
10.0
HPH2
10.0
SPF30
10.0
PIK3C2B
10.0
cryptochrome 2
9.8
XPE
9.7
high mobility group 1 protein
9.7
calcium binding and coiled-coil domain 2
9.7
A. nidulans)
9.6
Sp3 transcription factor
9.6
CRY2
9.5
REDD2
9.4
Micrococcus luteus UV endonuclease
9.4
CPD
9.4
adenylosuccinate synthase
9.4
PKE
9.4
DLAD
9.4
hPR
9.3
damage-specific DNA binding protein 1
9.3
ALT2
9.2
REC1
9.2
GDE1
9.2
DNA repair enzyme
9.1
CHOD
9.1
TRE
9.1
CEBPG
9.0
PREP1
8.9
SET7
8.9
SIGMAR1
8.9
PUB
8.9
PBX2
8.8
BLR1
8.8
myeloid zinc finger 1
8.8
DET1
8.8
CCT1
8.8
RHAU
8.7
HLA-B*5801
8.7
Ari
8.7
NPH1
8.7
Int6
8.7
DEL1
8.7
CCT2
8.7
sigma receptor
8.6
LRP130
8.6
tetratricopeptide repeat protein
8.4
TRN
8.3
CLOCK protein
8.3
excision repair protein
8.2
FAD
8.2
C1 protein
8.1
BCKDH
8.1
RAD1
8.1
MTE
8.1
MED25
8.0
PLP2
8.0
Prolactin receptor
8.0
ung
8.0
Suppressor of cytokine signaling 3
8.0
JAK2 protein
8.0
Z-protein
7.9
MZF1
7.9
Pol protein
7.9
CLOCK
7.8
ELOVL4
7.8
EBI1
7.8
MF1
7.8
BMAL1
7.7
NOR1
7.7
RAD23B
7.7
TFDP3
7.7
pheromone receptor
7.7
MED4
7.7
Rvb2
7.6
trithorax
7.6
REC
7.5
COP1
7.5
COX4
7.5
SYN
7.5
SMYD3
7.5
EXP
7.5
hemoglobin beta
7.5
RRF
7.4
TMF
7.4
AN2
7.4
trichothiodystrophy
7.3
HOX11
7.3
RPA32
7.3
helix-loop-helix protein
7.3
CCL14
7.3
MLL4
7.3
SRAP
7.3
IGM
7.3
SE2
7.3
RAD24
7.3
HSPD1
7.3
HOXA7
7.3
DNA polymerase zeta
7.3
OCRL
7.3
bicarbonate transporter
7.2
PBK
7.2
p59
7.2
MAD1
7.2
K79
7.2
MAZ
7.2
PAX-5
7.1
epsilon-globin
7.1
NFATp
7.1
myosin light chain-2
7.1
DDB2
7.0
HMGB2
7.0
NDC80
7.0
REV7
7.0
NL1
7.0
RIF1
6.9
HLS
6.9
Progesterone receptor
6.9
flavoprotein
6.9
SV2A
6.9
SRC1
6.9
LSR
6.8
ATG3
6.8
B1R
6.8
TIMELESS
6.8
REDD1
6.8
CYC1
6.8
NDP52
6.8
SRR
6.8
IBP
6.7
EF-hand protein
6.7
REV1
6.7
BASE
6.7
actin beta
6.7
RNR2
6.7
macrophage-stimulating protein
6.7
TAF1
6.7
XPB
6.7
RAD51B
6.7
REV3
6.7
AP lyase
6.7
integrin alpha 6
6.7
PER2
6.6
SIT
6.6
PFKFB3
6.6
SET8
6.6
more...
Disease
CHRS
10.6
COND
10.3
BOE
10.1
XPE
9.6
Fowlpox
9.3
pediatric liver cancer
8.6
EBSS
8.5
Polymorphic light eruption
8.4
XP-A
8.2
Shope fibroma
7.8
xeroderma pigmentosum
7.4
trichothiodystrophy
7.1
AN2
6.6
hypo-osmolality
6.5
Choroid
6.4
Choroid
6.4
XPD
6.3
CSB
6.0
HBD
6.0
CSB
5.9
complete paraplegia
5.9
PIE
5.9
rind
5.8
BPP
5.8
RP18
5.8
autoimmune lymphoproliferative syndrome
5.8
BED
5.8
NPHP1
5.8
trance
5.7
keratosis
5.7
XPB
5.6
HIV encephalitis
5.6
Lowe syndrome
5.5
DIN
5.5
DIN
5.5
SCA1
5.4
PER
5.4
Bronchiolitis obliterans
5.4
ABS
5.2
CHR
5.2
CSE
5.2
Parry
5.2
ABS
5.1
HRS
5.1
mononeuritis
5.0
Lower limb
5.0
alcohol withdrawal syndrome
5.0
avian leukosis
5.0
Diaphragm
5.0
ICT
4.9
MTC
4.9
behavior problem
4.9
PPP
4.8
Cockayne syndrome
4.8
McArdle's disease
4.8
Habituation
4.8
separation anxiety
4.8
AIP
4.8
skin cancer
4.7
AIP
4.7
postmenopausal bone loss
4.6
hepatoblastoma
4.6
hermaphroditism
4.6
INS
4.5
keratoacanthoma
4.5
PCS
4.5
ERS
4.5
psychosomatic disorders
4.5
COL2A1
4.5
Medulloblastoma
4.4
amnesia
4.4
tobacco dependence
4.4
Zellweger syndrome
4.4
NLS
4.4
lentigo
4.3
measurable disease
4.3
HDL2
4.3
HDL3
4.3
PCC
4.3
beta thalassemia
4.2
metritis
4.2
Hermansky-Pudlak syndrome
4.2
CEP
4.2
SCS
4.2
Rhabdomyosarcoma
4.1
HP1
4.1
CAA
4.1
mountain sickness
4.0
photosensitivity
4.0
HES
3.9
proliferative vitreoretinopathy
3.9
Spinal muscular atrophy
3.9
Ovary
3.9
Cirrhosis
3.9
herniated disc
3.9
PIN
3.9
ICC
3.8
ICC
3.8
CIN
3.8
ISS
3.8
nocturia
3.8
IMT
3.7
Frey
3.7
CAA
3.7
Hymenolepis
3.6
bronchopulmonary dysplasia
3.6
infectious endocarditis
3.5
esophageal atresia
3.5
EMD
3.5
Mitchell
3.5
TTP
3.5
delirium
3.5
psychological stress
3.4
senile dementia
3.4
AIN
3.4
SAD
3.3
endometrial adenocarcinoma
3.3
dystocia
3.2
FBS
3.2
Ovary
3.2
disc degeneration
3.1
Gilbert
3.1
Tumour necrosis
3.1
gestational trophoblastic disease
3.1
TAM
3.0
tapeworm
3.0
prediabetes
3.0
carcinosarcoma
3.0
pheochromocytoma
3.0
Marek's disease
3.0
TTP
2.9
precocious puberty
2.9
SCT
2.9
alkalosis
2.9
lice
2.8
paracoccidioidomycosis
2.8
drug withdrawal
2.8
memory impairment
2.8
lymphedema
2.8
HTLV-I
2.8
neoplastic transformation
2.7
STS
2.7
social stress
2.7
HSP
2.7
adult T-cell leukemia/lymphoma
2.7
Haemophilus
2.7
prostatic adenocarcinoma
2.7
HGF
2.7
GPS
2.6
viral diarrhea
2.6
bronchospasm
2.5
motor neuron disease
2.5
cholera
2.5
CTX
2.5
Rous sarcoma
2.5
carcinoma in situ
2.4
paraplegia
2.4
drug addiction
2.4
hyperkeratosis
2.4
necrotizing enterocolitis
2.4
more...
Symptom
Psychiatric symptoms
5.7
Halo
5.2
skin damage
5.0
exhaustion
4.4
muscle stiffness
3.8
fatigue
3.7
Neuropathic pain
3.5
bloating
3.3
hunger
3.1
tense
2.9
erythema
2.9
pallor
2.7
overweight
2.5
constipation
2.3
acute pain
2.1
analgesia
2.0
discomfort
1.9
wheezing
1.8
discomfort
1.8
low back pain
1.7
numbness
1.7
hyperoxia
1.7
cachexia
1.6
hypotonia
1.5
sleepiness
1.4
myalgia
1.3
nausea
1.1
anesthesia
1.0
collapse
0.8
nausea and vomiting
0.8
pain
0.6
agitation
0.5
weakness
0.4
stigma
0.3
seizures
0.0
tremor
-0.2
diarrhea
-0.2
starvation
-0.6
dyspnea
-0.8
headache
-0.8
Drug
Posilac
8.7
FAD
8.2
Trilostane
7.2
Lutalyse
7.1
FSH-beta
7.0
FSH-beta
7.0
FSH-beta
6.7
Escitalopram
6.1
GNA
5.9
Pregnenolone
5.8
Flavin
5.6
CTT
5.3
Finasteride
5.2
Gabapentin
5.2
MTC
5.0
Sinemet
4.9
Orphan
4.9
Donepezil
4.9
GHRP
4.9
TES
4.9
NBT
4.6
Camp
4.5
OTC
4.5
PMEA
4.5
Bupivacaine
4.4
DEX
4.2
Sodium nitroprusside
4.1
-deoxyadenosine
4.0
OTC
4.0
DMI
4.0
Fragment
3.8
DNase I
3.8
Horizon
3.8
Fentanyl
3.7
IL-1ra
3.6
Prednisolone
3.5
Growth hormone
3.5
Growth hormone
3.4
balanced salt solution
3.4
MAP
3.4
ADM
3.4
Triclosan
3.4
PTC
3.2
ABC
3.2
Posture
3.2
PCP
3.2
Parkin
3.2
Parkin
3.1
Bifidobacterium
3.1
Glycerol
2.8
CDP
2.8
AZT
2.6
caffeine
2.6
ALA
2.6
CTX
2.6
CTX
2.5
CAM
2.5
Mutagen
2.5
AZT
2.4
Vitamin E
2.3
Kenyan
2.2
EE2
2.1
THF
2.0
NADH
1.9
Albumin
1.8
CTX
1.7
lactose
1.6
IL-2
1.5
Asn
1.5
Gel
1.2
ROC
1.1
Biopolymers
1.0
vitamin E
0.9
Nephron
0.9
ROS
0.8
IFN-gamma
0.8
lysine
0.8
citric acid
0.7
Leaf
0.6
Dermatol
0.3
Dial
0.1
CSF
-0.9
Monit
-1.1
Cardiovasc
-3.6
Enzyme
PRE
14.0
N-methylglutamate synthase
13.0
HY2
8.8
deoxyribonuclease
8.0
endonuclease V
7.8
DNA ligase
7.8
DNA ligase
7.8
chorismate synthase
7.6
AP lyase
7.1
hydroxynitrile lyase
7.0
hydroxynitrile lyase
7.0
endodeoxyribonuclease
6.9
hydroxynitrile lyase
6.8
protochlorophyllide oxidoreductase
6.7
adenylosuccinate synthetase
6.3
venom phosphodiesterase
6.2
cytochrome c peroxidase
6.2
tannase
5.9
LIS
5.8
phospholipid hydroperoxide glutathione peroxidase
5.6
branched-chain alpha-keto acid dehydrogenase
5.4
3'-exonuclease
5.4
PST
5.3
DNase II
5.3
Protein 2
5.3
tyrosine aminotransferase
5.2
CGT
5.2
DMT
5.1
chalcone synthase
5.0
arginine decarboxylase
5.0
5alpha-reductase
5.0
5alpha-reductase
5.0
PRA
4.9
citrate synthase
4.9
ribonucleotide reductase
4.9
ribonucleotide reductase
4.8
arginine decarboxylase
4.7
cysteine synthase
4.7
endonuclease
4.7
cellulose synthase
4.7
GTP cyclohydrolase I
4.7
polynucleotide kinase
4.6
3-hydroxyacyl-CoA dehydrogenase
4.6
mu-calpain
4.6
GCA
4.6
CEP
4.5
creatine kinase
4.5
FAST
4.4
m-calpain
4.3
lignin peroxidase
4.2
ferrochelatase
4.2
Rex
4.2
MPP
4.1
GAS
4.1
SCS
4.0
calcium pump
4.0
RNase III
4.0
CEP
3.9
nitrogenase
3.8
cellulose synthase
3.7
histone acetyltransferase
3.6
LPL
3.6
DAT
3.5
thymidine kinase
3.5
sialyltransferase
3.4
sialyltransferase
3.4
sialyltransferase
3.4
chloramphenicol acetyltransferase
3.3
DNA polymerase
3.3
ornithine transcarbamylase
3.3
succinic dehydrogenase
3.2
thymidylate synthase
3.2
S1 nuclease
3.2
PCP
3.1
phosphofructokinase
3.1
dihydrofolate reductase
3.1
adenylate kinase
3.1
RNA polymerase
3.0
AMPK
3.0
HIV-1 protease
3.0
NADH dehydrogenase
3.0
complex I
2.9
PKG
2.7
hypoxanthine-guanine phosphoribosyltransferase
2.7
beta-glucuronidase
2.7
glucose-6-phosphate dehydrogenase
2.7
SPC
2.7
AMP-activated protein kinase
2.7
hexokinase
2.7
micrococcal nuclease
2.6
beta-galactosidase
2.5
AST
2.4
caspase-1
2.4
luciferase
2.4
GSK
2.3
caspase-8
2.3
hydrogenase
2.2
ATP synthase
2.2
hydrogenase
2.2
aspartate aminotransferase
2.2
lactate dehydrogenase
2.2
MAP
2.2
DNase
2.1
proteinase K
2.0
succinate dehydrogenase
2.0
AMPK
2.0
cdc2
2.0
cathepsin B
2.0
xanthine oxidase
2.0
MMP
2.0
glutathione peroxidase
1.9
focal adhesion kinase
1.9
topoisomerase
1.9
malate dehydrogenase
1.9
glyceraldehyde-3-phosphate dehydrogenase
1.8
IKK
1.8
topoisomerase
1.7
adenosine deaminase
1.7
NADPH oxidase
1.7
adenosine deaminase
1.7
alkaline phosphatase
1.6
lysozyme
1.6
glucose oxidase
1.6
glyceraldehyde-3-phosphate dehydrogenase
1.6
NADPH oxidase
1.6
calcineurin
1.5
superoxide dismutase
1.5
MEK
1.5
lipase
1.4
mitogen-activated protein kinase
1.4
glyceraldehyde-3-phosphate dehydrogenase
1.3
aldehyde dehydrogenase
1.3
PARP
1.3
lipoprotein lipase
1.2
caspase-3
1.2
caspase-9
1.1
catalase
1.1
cytochrome oxidase
0.9
alanine aminotransferase
0.9
renin
0.9
gamma-glutamyl transpeptidase
0.9
tyrosinase
0.9
proteasome
0.8
urokinase-type plasminogen activator
0.6
chymotrypsin
0.6
phosphatidylinositol 3-kinase
0.6
glutathione S-transferase
0.6
protein kinase C
0.4
acid phosphatase
0.4
ATPase
0.3
thromboplastin
0.3
ERK
0.3
acetylcholinesterase
0.2
NO synthase
0.1
collagenase
-0.1
phospholipase C
-0.2
adenylate cyclase
-0.2
peroxidase
-0.4
ACS
-0.7
reverse transcriptase
-0.9
more...
Compound
BC 75
14.0
5,10-methenyltetrahydrofolate
11.9
Isopimaric acid
10.8
Glycin
9.8
5-Bromouracil
9.8
thietane
9.7
PPBP
9.5
4-iodobenzamide
9.2
oxetane
9.1
2-mercaptosuccinic acid
9.0
pyrimidine
8.5
pyrimidine
8.4
FAD
8.2
Pterin
8.0
FK520
7.7
Acriflavine
7.4
Pregnane
7.4
10-formyltetrahydrofolate
7.3
B 5
7.3
Fluvoxamine
7.2
diethyl malonate
6.9
diethyl malonate
6.9
Phytoene
6.9
Phytoene
6.9
Pseudouridine
6.9
Efron
6.8
Practolol
6.7
IBP
6.7
TMG
6.7
IBP
6.7
Ajmaline
6.7
TMF
6.6
Mibefradil
6.6
CUE
6.5
Esmolol
6.5
PAE
6.4
EAA
6.4
MOD
6.3
pregnane-3,20-dione
6.3
Pentazocine
6.3
PRD
6.2
pregnane-3,20-dione
6.2
Flavin
6.2
Pentazocine
6.1
Ecdysone
6.0
Cyanidin
5.9
Pregnenolone
5.8
DMPP
5.8
Paeoniflorin
5.8
NPR
5.8
Psoralen
5.7
Diacetyl
5.7
Sitosterol
5.6
Phalloidin
5.6
Meloxicam
5.6
Cefazolin
5.6
Kynurenic acid
5.5
Nonylphenol
5.4
HN2
5.4
TES
5.3
Morin
5.3
SPF
5.2
Phenoxybenzamine
5.2
Glyphosate
5.2
MPA
5.2
MPA
5.2
MPA
5.1
Leucovorin
5.1
Crystal Violet
5.1
Factor X
5.1
DMT
5.1
FMN
5.0
undecane
5.0
XPA
5.0
Zirconia
5.0
XPA
5.0
MTC
5.0
Carnosine
5.0
DMS
5.0
Phenylalanine
5.0
Desipramine
5.0
RU-486
4.9
B17
4.9
DMT
4.9
DAP
4.9
DAP
4.9
NMP
4.8
tryptophan
4.8
tryptophan
4.8
tryptophan
4.8
DBD
4.8
methyl methanesulfonate
4.8
Thiamine
4.8
Cortisol
4.7
dipropyl
4.7
Match
4.7
TET
4.7
TET
4.7
Glyphosate
4.7
EPC
4.6
tryptophan
4.6
PNU
4.6
TTA
4.6
Rhodopsin
4.6
Quinone
4.6
NBT
4.5
DAMP
4.5
DIM
4.5
Apigenin
4.5
Nimodipine
4.5
Bupivacaine
4.5
pteridine
4.4
Triclosan
4.4
DEA
4.4
DEA
4.4
3-methylhistidine
4.4
DPC
4.4
DPC
4.4
Prednisone
4.3
DEA
4.3
Progesterone
4.3
PAR
4.3
1,4,7,10-tetraazacyclododecane
4.3
MPP
4.3
Flux
4.3
DEX
4.2
MPP
4.2
MSG
4.2
nitrous acid
4.2
Dobutamine
4.2
Adenine
4.1
MOP
4.1
MEP
4.0
FAP
4.0
FAP
4.0
beta-alanine
4.0
piperidine
4.0
piperidine
4.0
CAA
4.0
Creatine
4.0
FFA
4.0
DMI
3.9
DMI
3.9
MEP
3.9
ACI
3.8
Taurine
3.8
T10
3.8
isopropanol
3.8
DNA
3.8
Bilirubin
3.8
hydroquinone
3.8
FTA
3.7
XTT
3.7
DPH
3.7
isopentenyl diphosphate
3.7
2,3-diphosphoglycerate
3.6
PEA
3.6
Titanium dioxide
3.6
DAMGO
3.6
dGTP
3.6
more...